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Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice.
Neurotoxicology. 2014 Mar; 41:80-8.N

Abstract

Current evidence suggests suceptibility of both the substantia nigra and striatum to exposure to components of air pollution. Further, air pollution has been associated with increased risk of PD diagnsosis in humans or PD-like pathology in animals. This study examined whether exposure of mice to concentrated ambient ultrafine particles (CAPS; <100nm diameter) during the first two weeks of life would alter susceptibility to induction of the Parkinson's disease phenyotype (PDP) in a pesticide-based paraquat and maneb (PQ+MB) model during adulthood utilizing i.p. injections of 10mg/kg PQ and 30mg/kg MB 2× per week for 6 weeks. Evidence of CAPS-induced enhancement of the PQ+MB PDP was limited primarily to delayed recovery of locomotor activity 24 post-injection of PQ+MB that could be related to alterations in striatal GABA inhibitory function. Absence of more extensive interactions might also reflect the finding that CAPS and PQ+MB appeared to differentially target the nigrostriatal dopamine and amino acid systems, with CAPS impacting striatum and PQ+MB impacting dopamine-glutamate function in midbrain; both CAPS and PQ+MB elevated glutamate levels in these specific regions, consistent with potential excitotoxicity. These findings demonstrate the ability of postnatal CAPS to produce locomotor dysfunction and dopaminergic and glutamateric changes, independent of PQ+MB, in brain regions involved in the PDP.

Authors+Show Affiliations

Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Electronic address: joshua_allen@urmc.rochester.edu.Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Electronic address: suexfliu@hotmail.com.Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Electronic address: douglas_weston@urmc.rochester.edu.Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Electronic address: Katherine_bachmann@urmc.rochester.edu.Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Electronic address: gunter_oberdorster@urmc.rochester.edu.Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Electronic address: deborah_cory-slechta@urmc.rochester.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24486957

Citation

Allen, Joshua L., et al. "Consequences of Developmental Exposure to Concentrated Ambient Ultrafine Particle Air Pollution Combined With the Adult Paraquat and Maneb Model of the Parkinson's Disease Phenotype in Male Mice." Neurotoxicology, vol. 41, 2014, pp. 80-8.
Allen JL, Liu X, Weston D, et al. Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. Neurotoxicology. 2014;41:80-8.
Allen, J. L., Liu, X., Weston, D., Conrad, K., Oberdörster, G., & Cory-Slechta, D. A. (2014). Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. Neurotoxicology, 41, 80-8. https://doi.org/10.1016/j.neuro.2014.01.004
Allen JL, et al. Consequences of Developmental Exposure to Concentrated Ambient Ultrafine Particle Air Pollution Combined With the Adult Paraquat and Maneb Model of the Parkinson's Disease Phenotype in Male Mice. Neurotoxicology. 2014;41:80-8. PubMed PMID: 24486957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. AU - Allen,Joshua L, AU - Liu,Xiufang, AU - Weston,Douglas, AU - Conrad,Katherine, AU - Oberdörster,Günter, AU - Cory-Slechta,Deborah A, Y1 - 2014/01/30/ PY - 2013/12/02/received PY - 2014/01/20/revised PY - 2014/01/21/accepted PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/11/15/medline KW - Parkinson's disease KW - Pesticides KW - Ultrafine Particles SP - 80 EP - 8 JF - Neurotoxicology JO - Neurotoxicology VL - 41 N2 - Current evidence suggests suceptibility of both the substantia nigra and striatum to exposure to components of air pollution. Further, air pollution has been associated with increased risk of PD diagnsosis in humans or PD-like pathology in animals. This study examined whether exposure of mice to concentrated ambient ultrafine particles (CAPS; <100nm diameter) during the first two weeks of life would alter susceptibility to induction of the Parkinson's disease phenyotype (PDP) in a pesticide-based paraquat and maneb (PQ+MB) model during adulthood utilizing i.p. injections of 10mg/kg PQ and 30mg/kg MB 2× per week for 6 weeks. Evidence of CAPS-induced enhancement of the PQ+MB PDP was limited primarily to delayed recovery of locomotor activity 24 post-injection of PQ+MB that could be related to alterations in striatal GABA inhibitory function. Absence of more extensive interactions might also reflect the finding that CAPS and PQ+MB appeared to differentially target the nigrostriatal dopamine and amino acid systems, with CAPS impacting striatum and PQ+MB impacting dopamine-glutamate function in midbrain; both CAPS and PQ+MB elevated glutamate levels in these specific regions, consistent with potential excitotoxicity. These findings demonstrate the ability of postnatal CAPS to produce locomotor dysfunction and dopaminergic and glutamateric changes, independent of PQ+MB, in brain regions involved in the PDP. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/24486957/Consequences_of_developmental_exposure_to_concentrated_ambient_ultrafine_particle_air_pollution_combined_with_the_adult_paraquat_and_maneb_model_of_the_Parkinson's_disease_phenotype_in_male_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(14)00017-5 DB - PRIME DP - Unbound Medicine ER -