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Cervical cancer screening by high risk HPV testing in routine practice: results at one year recall of high risk HPV-positive and cytology-negative women.
J Med Screen 2014; 21(1):30-7JM

Abstract

OBJECTIVE

Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women's compliance with and the performance of this strategy in a routine setting.

SETTING

Five cervical service screening programmes in North-East Italy.

METHODS

Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology results were referred for colposcopy; women with positive HPV but negative cytology results were referred to 1-year repeat hrHPV testing.

RESULTS

Of 46,694 women screened by HPV testing up to December 2011, 3,211 (6.9%) tested hrHPV positive; 45% of these had a positive triage cytology. Those with negative cytology were invited for 1-yr repeat testing. Compliance with invitation was 61.6% at baseline and 85.3% at 1-yr repeat. Rate of persistent hrHPV positivity was 58% (830/1,435). Colposcopy performed in women with a positive hrHPV test at 1-yr repeat accounted for 36% of all colposcopies performed within the screening programmes. Cumulatively, a histological high-grade lesion was detected in 276 women (5.9‰ detection rate), 234 at baseline (85%), and 42 (15%) at 1-yr repeat.

CONCLUSIONS

Compliance with hrHPV-based screening programmes was high both at baseline and at 1-yr repeat. Compared with the randomized trials, a higher proportion of triage cytology was read as positive, and only a small number of high-grade lesions were detected among the group of hrHPV positive cytology negative women who repeated testing 1-yr after baseline.

Authors+Show Affiliations

Immunology and Molecular Oncology Unit, Veneto Oncology Institute IOV IRCCS, Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24488593

Citation

Del Mistro, Annarosa, et al. "Cervical Cancer Screening By High Risk HPV Testing in Routine Practice: Results at One Year Recall of High Risk HPV-positive and Cytology-negative Women." Journal of Medical Screening, vol. 21, no. 1, 2014, pp. 30-7.
Del Mistro A, Frayle H, Ferro A, et al. Cervical cancer screening by high risk HPV testing in routine practice: results at one year recall of high risk HPV-positive and cytology-negative women. J Med Screen. 2014;21(1):30-7.
Del Mistro, A., Frayle, H., Ferro, A., Callegaro, S., Del Sole, A., Stomeo, A., ... Zorzi, M. (2014). Cervical cancer screening by high risk HPV testing in routine practice: results at one year recall of high risk HPV-positive and cytology-negative women. Journal of Medical Screening, 21(1), pp. 30-7. doi:10.1177/0969141314522219.
Del Mistro A, et al. Cervical Cancer Screening By High Risk HPV Testing in Routine Practice: Results at One Year Recall of High Risk HPV-positive and Cytology-negative Women. J Med Screen. 2014;21(1):30-7. PubMed PMID: 24488593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cervical cancer screening by high risk HPV testing in routine practice: results at one year recall of high risk HPV-positive and cytology-negative women. AU - Del Mistro,Annarosa, AU - Frayle,Helena, AU - Ferro,Antonio, AU - Callegaro,Susanna, AU - Del Sole,Annamaria, AU - Stomeo,Anna, AU - Cirillo,Emanuela, AU - Fedato,Chiara, AU - Pagni,Silvana, AU - Barzon,Luisa, AU - Zorzi,Manuel, AU - ,, Y1 - 2014/01/31/ PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/11/14/medline KW - HPV KW - follow-up KW - organized screening KW - triage SP - 30 EP - 7 JF - Journal of medical screening JO - J Med Screen VL - 21 IS - 1 N2 - OBJECTIVE: Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women's compliance with and the performance of this strategy in a routine setting. SETTING: Five cervical service screening programmes in North-East Italy. METHODS: Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology results were referred for colposcopy; women with positive HPV but negative cytology results were referred to 1-year repeat hrHPV testing. RESULTS: Of 46,694 women screened by HPV testing up to December 2011, 3,211 (6.9%) tested hrHPV positive; 45% of these had a positive triage cytology. Those with negative cytology were invited for 1-yr repeat testing. Compliance with invitation was 61.6% at baseline and 85.3% at 1-yr repeat. Rate of persistent hrHPV positivity was 58% (830/1,435). Colposcopy performed in women with a positive hrHPV test at 1-yr repeat accounted for 36% of all colposcopies performed within the screening programmes. Cumulatively, a histological high-grade lesion was detected in 276 women (5.9‰ detection rate), 234 at baseline (85%), and 42 (15%) at 1-yr repeat. CONCLUSIONS: Compliance with hrHPV-based screening programmes was high both at baseline and at 1-yr repeat. Compared with the randomized trials, a higher proportion of triage cytology was read as positive, and only a small number of high-grade lesions were detected among the group of hrHPV positive cytology negative women who repeated testing 1-yr after baseline. SN - 1475-5793 UR - https://www.unboundmedicine.com/medline/citation/24488593/Cervical_cancer_screening_by_high_risk_HPV_testing_in_routine_practice:_results_at_one_year_recall_of_high_risk_HPV_positive_and_cytology_negative_women_ L2 - http://journals.sagepub.com/doi/full/10.1177/0969141314522219?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -