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Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction.
Planta Med. 2014 Feb; 80(2-3):159-64.PM

Abstract

Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both herbs have to work harmoniously in order to achieve the maximal therapeutic purposes. In order to analyze the relationship of the two herbs, the role of ferulic acid, a major chemical within Angelicae sinensis radix, in chemical and biological properties of astragali radix was determined. Using ferulic acid in the extraction of astragali radix, the amounts of astragaloside IV, calycosin, and formononetin were increased in the final extract; however, the astragali radix polysaccharide showed a minor increase. The chemical-enriched astragali radix extract showed robust induction in osteogenic and estrogenic activities in cultured osteosarcoma MG-63 and breast MCF-7 cells. However, ferulic acid itself did not show such biological responses. The current results strongly suggest that Angelicae sinensis radix-derived ferulic acid is a positive regulator for danggui buxue tang, which enhanced the solubilities of active ingredients derived from astragali radix, and which therefore increased the biological efficacies of danggui buxue tang.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Biology, Hanshan Normal University, Chaozhou, Guangdong, China.

Department of Biology, Hanshan Normal University, Chaozhou, Guangdong, China.

Department of Biology, Hanshan Normal University, Chaozhou, Guangdong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.

MeSH

Astragalus PlantAstragalus propinquusCell LineCell ProliferationChromatography, High Pressure LiquidCoumaric AcidsDrug SynergismDrugs, Chinese HerbalEstrogensHumansMCF-7 CellsSolubility

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24488720

Citation

Zheng, Ken Y Z., et al. "Ferulic Acid Enhances the Chemical and Biological Properties of Astragali Radix: a Stimulator for Danggui Buxue Tang, an Ancient Chinese Herbal Decoction." Planta Medica, vol. 80, no. 2-3, 2014, pp. 159-64.

Zheng KY, Zhang ZX, Du CY, et al. Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction. Planta Med. 2014;80(2-3):159-64.

Zheng, K. Y., Zhang, Z. X., Du, C. Y., Zhang, W. L., Bi, C. W., Choi, R. C., Dong, T. T., & Tsim, K. W. (2014). Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction. Planta Medica, 80(2-3), 159-64. https://doi.org/10.1055/s-0033-1360314

Zheng KY, et al. Ferulic Acid Enhances the Chemical and Biological Properties of Astragali Radix: a Stimulator for Danggui Buxue Tang, an Ancient Chinese Herbal Decoction. Planta Med. 2014;80(2-3):159-64. PubMed PMID: 24488720.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction. AU - Zheng,Ken Y Z, AU - Zhang,Zhen X, AU - Du,Crystal Y Q, AU - Zhang,Wendy L, AU - Bi,Cathy W C, AU - Choi,Roy C Y, AU - Dong,Tina T X, AU - Tsim,Karl W K, Y1 - 2014/01/31/ PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/11/8/medline SP - 159 EP - 64 JF - Planta medica JO - Planta Med VL - 80 IS - 2-3 N2 - Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both herbs have to work harmoniously in order to achieve the maximal therapeutic purposes. In order to analyze the relationship of the two herbs, the role of ferulic acid, a major chemical within Angelicae sinensis radix, in chemical and biological properties of astragali radix was determined. Using ferulic acid in the extraction of astragali radix, the amounts of astragaloside IV, calycosin, and formononetin were increased in the final extract; however, the astragali radix polysaccharide showed a minor increase. The chemical-enriched astragali radix extract showed robust induction in osteogenic and estrogenic activities in cultured osteosarcoma MG-63 and breast MCF-7 cells. However, ferulic acid itself did not show such biological responses. The current results strongly suggest that Angelicae sinensis radix-derived ferulic acid is a positive regulator for danggui buxue tang, which enhanced the solubilities of active ingredients derived from astragali radix, and which therefore increased the biological efficacies of danggui buxue tang. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/24488720/Ferulic_acid_enhances_the_chemical_and_biological_properties_of_astragali_radix:_a_stimulator_for_danggui_buxue_tang_an_ancient_Chinese_herbal_decoction_ DB - PRIME DP - Unbound Medicine ER -