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The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Toxicon 2014; 81:37-42T

Abstract

This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM). Repeated administration of reserpine (0.25 mg/kg sc) once daily for three consecutive days significantly decreased thermal hyperalgesia, mechanical allodynia, and dopamine and serotonin content in the brain on the 4th day. Phα1β and pregabalin treatment completely reverted the mechanical allodynia and thermal hyperalgesia induced by reserpine treatment on the 4th day, but diclofenac was ineffective. Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals. Phα1β, but not pregabalin, reduced the immobility time (56%), suggesting that Phα1β may control persistent pathological pain in FM.

Authors+Show Affiliations

Programa de Pós-Graduação em Genética e Toxicologia Aplicada (PPGGTA), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBioSaúde), ULBRA, Canoas, RGS, Brazil.Programa de Pós Graduação Biomedicina e Medicina, Instituto de Ensino e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil.Programa de Pós Graduação Biomedicina e Medicina, Instituto de Ensino e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil.Programa de Pós Graduação em Farmacologia Bioquimica e Molecular, Faculdade Medicina UFMG, Belo Horizonte, MG, Brazil.Programa de Pos Graduação em Biologia Celular e Molecular da Pontificia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RGS, Brazil.Programa de Pós Graduação Biomedicina e Medicina, Instituto de Ensino e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil.Programa de Pós Graduação em Farmacologia Bioquimica e Molecular, Faculdade Medicina UFMG, Belo Horizonte, MG, Brazil.Programa de Pós Graduação em Farmacologia UFSM, Santa Maria, RGS, Brazil.Programa de Pós Graduação Biomedicina e Medicina, Instituto de Ensino e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil; Programa de Pós Graduação em Farmacologia Bioquimica e Molecular, Faculdade Medicina UFMG, Belo Horizonte, MG, Brazil. Electronic address: marcusvgomez@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24491352

Citation

de Souza, Alessandra Hubner, et al. "The Effects of Phα1β, a Spider Toxin, Calcium Channel Blocker, in a Mouse Fibromyalgia Model." Toxicon : Official Journal of the International Society On Toxinology, vol. 81, 2014, pp. 37-42.
de Souza AH, da Costa Lopes AM, Castro CJ, et al. The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. Toxicon. 2014;81:37-42.
de Souza, A. H., da Costa Lopes, A. M., Castro, C. J., Pereira, E. M., Klein, C. P., da Silva, C. A., ... Gomez, M. V. (2014). The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. Toxicon : Official Journal of the International Society On Toxinology, 81, pp. 37-42. doi:10.1016/j.toxicon.2014.01.015.
de Souza AH, et al. The Effects of Phα1β, a Spider Toxin, Calcium Channel Blocker, in a Mouse Fibromyalgia Model. Toxicon. 2014;81:37-42. PubMed PMID: 24491352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. AU - de Souza,Alessandra Hubner, AU - da Costa Lopes,Aírton Martins, AU - Castro,Célio J,Jr AU - Pereira,Elizete Maria Rita, AU - Klein,Caroline Peres, AU - da Silva,Claudio Antonio,Jr AU - da Silva,Juliana Figueira, AU - Ferreira,Juliano, AU - Gomez,Marcus Vinicius, Y1 - 2014/01/31/ PY - 2013/11/22/received PY - 2014/01/15/revised PY - 2014/01/23/accepted PY - 2014/2/5/entrez PY - 2014/2/5/pubmed PY - 2014/12/30/medline KW - Diclofenac KW - Fibromyalgia model KW - Phα1β KW - Pregabalin KW - Treatment SP - 37 EP - 42 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 81 N2 - This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM). Repeated administration of reserpine (0.25 mg/kg sc) once daily for three consecutive days significantly decreased thermal hyperalgesia, mechanical allodynia, and dopamine and serotonin content in the brain on the 4th day. Phα1β and pregabalin treatment completely reverted the mechanical allodynia and thermal hyperalgesia induced by reserpine treatment on the 4th day, but diclofenac was ineffective. Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals. Phα1β, but not pregabalin, reduced the immobility time (56%), suggesting that Phα1β may control persistent pathological pain in FM. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/24491352/The_effects_of_Phα1β_a_spider_toxin_calcium_channel_blocker_in_a_mouse_fibromyalgia_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(14)00028-2 DB - PRIME DP - Unbound Medicine ER -