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Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan.
Cancer Res 1988; 48(5):1331-6CR

Abstract

One hundred patients with prostate cancer and two different control series [100 benign prostatic hyperplasia (BPH) patients and 100 general hospital patients] were matched to each other upon hospital admittance, age (+/- 3 years) and date of admission (+/- 3 months), and directly interviewed during admission from 1981 to 1984 in Kyoto, Japan. Major dietary findings derived from a quantitative food frequency technique for estimating usual diet are as follows. (a) The smaller the dietary intake of beta-carotene and vitamin A as well, the higher the risk, with a highly significant linear trend. From the beta-carotene analyses, the relative risk (95% confidence interval) for the lowest intake quartile relative to the highest was 2.10 (0.98-4.47) for the uncorrected intake, 2.35 (1.08-5.12) for the intake per kg, and 2.94 (1.34-6.44) for the intake per kcal in the comparison with BPH patients; 2.88 (1.31-6.32), 2.56 (1.14-5.76), and 3.50 (1.52-8.06), respectively, in the comparison with hospital controls. The corresponding relative risk obtained from the vitamin A analyses was 2.82 (1.30-6.14), 2.64 (1.24-5.60), and 3.29 (1.47-7.35) in due order in the comparison with BPH patients; 2.69 (1.22-5.94), 4.78 (1.98-11.52), and 3.50 (1.52-8.06) in the comparison with hospital controls. (b) beta-Carotene as well as vitamin A contained in green/yellow vegetables were significantly protective, and those in seaweeds and kelp suggestively protective. But those in fruits appeared to enhance the risk. (c) The risk reduction by dietary beta-carotene and vitamin A was significant in the older men (70-79 years), but not in the younger men (50-69 years). (d) Total energy intake and the dietary intake of fat, protein, carbohydrate, water, fiber, ash, such vitamins as retinol, B1, B2, C, and niacin, and such minerals as calcium, potassium, sodium, phosphorus, and iron were not linked with prostate cancer risk. (e) A protective effect of dietary beta-carotene and vitamin A against prostate cancer could be related to the low overall fat intake in Japan.

Authors+Show Affiliations

Department of Public Health, Nagoya City University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2449278

Citation

Ohno, Y, et al. "Dietary Beta-carotene and Cancer of the Prostate: a Case-control Study in Kyoto, Japan." Cancer Research, vol. 48, no. 5, 1988, pp. 1331-6.
Ohno Y, Yoshida O, Oishi K, et al. Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan. Cancer Res. 1988;48(5):1331-6.
Ohno, Y., Yoshida, O., Oishi, K., Okada, K., Yamabe, H., & Schroeder, F. H. (1988). Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan. Cancer Research, 48(5), pp. 1331-6.
Ohno Y, et al. Dietary Beta-carotene and Cancer of the Prostate: a Case-control Study in Kyoto, Japan. Cancer Res. 1988 Mar 1;48(5):1331-6. PubMed PMID: 2449278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan. AU - Ohno,Y, AU - Yoshida,O, AU - Oishi,K, AU - Okada,K, AU - Yamabe,H, AU - Schroeder,F H, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 1331 EP - 6 JF - Cancer research JO - Cancer Res. VL - 48 IS - 5 N2 - One hundred patients with prostate cancer and two different control series [100 benign prostatic hyperplasia (BPH) patients and 100 general hospital patients] were matched to each other upon hospital admittance, age (+/- 3 years) and date of admission (+/- 3 months), and directly interviewed during admission from 1981 to 1984 in Kyoto, Japan. Major dietary findings derived from a quantitative food frequency technique for estimating usual diet are as follows. (a) The smaller the dietary intake of beta-carotene and vitamin A as well, the higher the risk, with a highly significant linear trend. From the beta-carotene analyses, the relative risk (95% confidence interval) for the lowest intake quartile relative to the highest was 2.10 (0.98-4.47) for the uncorrected intake, 2.35 (1.08-5.12) for the intake per kg, and 2.94 (1.34-6.44) for the intake per kcal in the comparison with BPH patients; 2.88 (1.31-6.32), 2.56 (1.14-5.76), and 3.50 (1.52-8.06), respectively, in the comparison with hospital controls. The corresponding relative risk obtained from the vitamin A analyses was 2.82 (1.30-6.14), 2.64 (1.24-5.60), and 3.29 (1.47-7.35) in due order in the comparison with BPH patients; 2.69 (1.22-5.94), 4.78 (1.98-11.52), and 3.50 (1.52-8.06) in the comparison with hospital controls. (b) beta-Carotene as well as vitamin A contained in green/yellow vegetables were significantly protective, and those in seaweeds and kelp suggestively protective. But those in fruits appeared to enhance the risk. (c) The risk reduction by dietary beta-carotene and vitamin A was significant in the older men (70-79 years), but not in the younger men (50-69 years). (d) Total energy intake and the dietary intake of fat, protein, carbohydrate, water, fiber, ash, such vitamins as retinol, B1, B2, C, and niacin, and such minerals as calcium, potassium, sodium, phosphorus, and iron were not linked with prostate cancer risk. (e) A protective effect of dietary beta-carotene and vitamin A against prostate cancer could be related to the low overall fat intake in Japan. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/2449278/Dietary_beta_carotene_and_cancer_of_the_prostate:_a_case_control_study_in_Kyoto_Japan_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2449278 DB - PRIME DP - Unbound Medicine ER -