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Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413.
Immunopharmacol Immunotoxicol. 1987; 9(4):511-21.II

Abstract

The effect of KB-2413 on IgE-mediated histamine and LTC4 release from leukocytes obtained from asthmatic patients who were sensitive to mites, and from human lung tissues passively sensitized with IgE myeloma serum was studied. KB-2413 inhibited the IgE-mediated chemical mediator release concentration dependently at a range of 10(-4) to 3 x 10(-3) M. KB-2413 did not enhance histamine release at a higher concentration unlike ketotifen. These findings suggest that the inhibitory effect of KB-2413 on the release of chemical mediators contributes to the anti-allergic activity of this compound.

Authors+Show Affiliations

Nishimura N
Pharmaceuticals Research Center, Kanebo Ltd., Osaka, Japan.
Ito K
No affiliation info available
Tomioka H
No affiliation info available
Yoshida S
No affiliation info available

MeSH

BenzimidazolesHistamine H1 AntagonistsHistamine ReleaseHumansHypersensitivityImmunoglobulin EIn Vitro TechniquesLeukocytesLungSRS-A

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2449488

Citation

Nishimura, N, et al. "Inhibition of Chemical Mediator Release From Human Leukocytes and Lung in Vitro By a Novel Antiallergic Agent, KB-2413." Immunopharmacology and Immunotoxicology, vol. 9, no. 4, 1987, pp. 511-21.
Nishimura N, Ito K, Tomioka H, et al. Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413. Immunopharmacol Immunotoxicol. 1987;9(4):511-21.
Nishimura, N., Ito, K., Tomioka, H., & Yoshida, S. (1987). Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413. Immunopharmacology and Immunotoxicology, 9(4), 511-21.
Nishimura N, et al. Inhibition of Chemical Mediator Release From Human Leukocytes and Lung in Vitro By a Novel Antiallergic Agent, KB-2413. Immunopharmacol Immunotoxicol. 1987;9(4):511-21. PubMed PMID: 2449488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413. AU - Nishimura,N, AU - Ito,K, AU - Tomioka,H, AU - Yoshida,S, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 511 EP - 21 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 9 IS - 4 N2 - The effect of KB-2413 on IgE-mediated histamine and LTC4 release from leukocytes obtained from asthmatic patients who were sensitive to mites, and from human lung tissues passively sensitized with IgE myeloma serum was studied. KB-2413 inhibited the IgE-mediated chemical mediator release concentration dependently at a range of 10(-4) to 3 x 10(-3) M. KB-2413 did not enhance histamine release at a higher concentration unlike ketotifen. These findings suggest that the inhibitory effect of KB-2413 on the release of chemical mediators contributes to the anti-allergic activity of this compound. SN - 0892-3973 UR - https://www.unboundmedicine.com/medline/citation/2449488/Inhibition_of_chemical_mediator_release_from_human_leukocytes_and_lung_in_vitro_by_a_novel_antiallergic_agent_KB_2413_ DB - PRIME DP - Unbound Medicine ER -