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[Different species of human rhinovirus infection in children with acute respiratory tract infections in Beijing].
Zhonghua Er Ke Za Zhi. 2013 Dec; 51(12):903-8.ZE

Abstract

OBJECTIVE

To understand the clinical characteristics of different groups human rhinovirus (HRV)-A, B and C infection in children with acute respiratory tract infections (ARI) in Beijing.

METHOD

Respiratory tract specimens (n = 1412) collected from children with ARI during Jan. 2011 to Dec. 2012 were tested for HRV by using semi-nested PCR. Gene fragments of VP4/VP2 capsid protein amplified from HRV positive specimens were sequenced for HRV genotype confirmation. Then epidemiological characteristics of these HRV-positive cases were analyzed.

RESULT

Among these 1412 specimens tested, 103 (7.3%) were HRV positive, including 54 (52.4%) positive for HRV-A, 14 (13.6%) for HRV-B, 35 (34.0%) for HRV-C determined by sequence analysis. The positive rates of HRV-A, B and C (2.5%, 16/638; 0.3%, 2/638 and 1.3%, 8/638) in children with acute upper respiratory tract infections (URI) were lower than those (5.8%, 36/623; 1.8%, 11/623 and 3.9%, 24/623) in children with acute lower respiratory tract infections (LRI) (P = 0.003, 0.011, 0.003). In children with LRI, the positive rates of HRV-A, C were similar to each other (P = 0.112), and both were higher than that of HRV-B (P = 0.000, P = 0.026). The severity of ARI among children positive for different groups HRV showed no significant difference evaluated by Kruskal-Wallis H test (Hc = 0.044, P > 0.05), as well as that between children co-infected with HRV and other viruses and those infected with HRV only evaluated by Wilcoxon rank sum test (Zc = 0.872, P > 0.05).

CONCLUSION

HRV is one of important pathogens for children with ARI, especially LRI in Beijing. The positive rates of HRV-A and HRV-C are similar to each other, and both are higher than that of HRV-B. No significant difference was shown among children with different HRV genotypes by evaluation of the severity of ARI, and co-infections of HRV with other viruses do not significantly increase the severity of ARI.

Authors+Show Affiliations

Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China. Email: linqingzhao@gmail.com.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

24495760

Citation

Song, Ming-hui, et al. "[Different Species of Human Rhinovirus Infection in Children With Acute Respiratory Tract Infections in Beijing]." Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, vol. 51, no. 12, 2013, pp. 903-8.
Song MH, Zhao LQ, Qian Y, et al. [Different species of human rhinovirus infection in children with acute respiratory tract infections in Beijing]. Zhonghua Er Ke Za Zhi. 2013;51(12):903-8.
Song, M. H., Zhao, L. Q., Qian, Y., Zhu, R. N., Deng, J., Wang, F., Sun, Y., & Tian, R. (2013). [Different species of human rhinovirus infection in children with acute respiratory tract infections in Beijing]. Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, 51(12), 903-8.
Song MH, et al. [Different Species of Human Rhinovirus Infection in Children With Acute Respiratory Tract Infections in Beijing]. Zhonghua Er Ke Za Zhi. 2013;51(12):903-8. PubMed PMID: 24495760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Different species of human rhinovirus infection in children with acute respiratory tract infections in Beijing]. AU - Song,Ming-hui, AU - Zhao,Lin-qing, AU - Qian,Yuan, AU - Zhu,Ru-nan, AU - Deng,Jie, AU - Wang,Fang, AU - Sun,Yu, AU - Tian,Run, PY - 2014/2/6/entrez PY - 2014/2/6/pubmed PY - 2014/9/5/medline SP - 903 EP - 8 JF - Zhonghua er ke za zhi = Chinese journal of pediatrics JO - Zhonghua Er Ke Za Zhi VL - 51 IS - 12 N2 - OBJECTIVE: To understand the clinical characteristics of different groups human rhinovirus (HRV)-A, B and C infection in children with acute respiratory tract infections (ARI) in Beijing. METHOD: Respiratory tract specimens (n = 1412) collected from children with ARI during Jan. 2011 to Dec. 2012 were tested for HRV by using semi-nested PCR. Gene fragments of VP4/VP2 capsid protein amplified from HRV positive specimens were sequenced for HRV genotype confirmation. Then epidemiological characteristics of these HRV-positive cases were analyzed. RESULT: Among these 1412 specimens tested, 103 (7.3%) were HRV positive, including 54 (52.4%) positive for HRV-A, 14 (13.6%) for HRV-B, 35 (34.0%) for HRV-C determined by sequence analysis. The positive rates of HRV-A, B and C (2.5%, 16/638; 0.3%, 2/638 and 1.3%, 8/638) in children with acute upper respiratory tract infections (URI) were lower than those (5.8%, 36/623; 1.8%, 11/623 and 3.9%, 24/623) in children with acute lower respiratory tract infections (LRI) (P = 0.003, 0.011, 0.003). In children with LRI, the positive rates of HRV-A, C were similar to each other (P = 0.112), and both were higher than that of HRV-B (P = 0.000, P = 0.026). The severity of ARI among children positive for different groups HRV showed no significant difference evaluated by Kruskal-Wallis H test (Hc = 0.044, P > 0.05), as well as that between children co-infected with HRV and other viruses and those infected with HRV only evaluated by Wilcoxon rank sum test (Zc = 0.872, P > 0.05). CONCLUSION: HRV is one of important pathogens for children with ARI, especially LRI in Beijing. The positive rates of HRV-A and HRV-C are similar to each other, and both are higher than that of HRV-B. No significant difference was shown among children with different HRV genotypes by evaluation of the severity of ARI, and co-infections of HRV with other viruses do not significantly increase the severity of ARI. SN - 0578-1310 UR - https://www.unboundmedicine.com/medline/citation/24495760/[Different_species_of_human_rhinovirus_infection_in_children_with_acute_respiratory_tract_infections_in_Beijing]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0578-1310&year=2013&vol=51&issue=12&fpage=903 DB - PRIME DP - Unbound Medicine ER -