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Sleep duration and depressive symptoms: a gene-environment interaction.
Sleep 2014; 37(2):351-8S

Abstract

OBJECTIVE

We used quantitative genetic models to assess whether sleep duration modifies genetic and environmental influences on depressive symptoms.

METHOD

Participants were 1,788 adult twins from 894 same-sex twin pairs (192 male and 412 female monozygotic [MZ] pairs, and 81 male and 209 female dizygotic [DZ] pairs] from the University of Washington Twin Registry. Participants self-reported habitual sleep duration and depressive symptoms. Data were analyzed using quantitative genetic interaction models, which allowed the magnitude of additive genetic, shared environmental, and non-shared environmental influences on depressive symptoms to vary with sleep duration.

RESULTS

Within MZ twin pairs, the twin who reported longer sleep duration reported fewer depressive symptoms (ec = -0.17, SE = 0.06, P < 0.05). There was a significant gene × sleep duration interaction effect on depressive symptoms (a'c = 0.23, SE = 0.08, P < 0.05), with the interaction occurring on genetic influences that are common to both sleep duration and depressive symptoms. Among individuals with sleep duration within the normal range (7-8.9 h/night), the total heritability (h2) of depressive symptoms was approximately 27%. However, among individuals with sleep duration within the low (< 7 h/night) or high (≥ 9 h/night) range, increased genetic influence on depressive symptoms was observed, particularly at sleep duration extremes (5 h/night: h2 = 53%; 10 h/night: h2 = 49%).

CONCLUSION

Genetic contributions to depressive symptoms increase at both short and long sleep durations.

Authors+Show Affiliations

Department of Neurology, University of Washington, Seattle, WA ; UW Medicine Sleep Center, University of Washington, Seattle, WA ; Center for Research on the Management of Sleep Disturbances, University of Washington, Seattle, WA.Department of Psychology, University of Texas at Austin, Austin, TX.Department of Epidemiology, University of Washington, Seattle, WA.Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA ; Center for Research on the Management of Sleep Disturbances, University of Washington, Seattle, WA.Division of Sleep Medicine/Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA.Department of Epidemiology, University of Washington, Seattle, WA ; Vietnam Era Twin Registry, VA Epidemiologic Research and Information Center, Seattle, WA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

24497663

Citation

Watson, Nathaniel F., et al. "Sleep Duration and Depressive Symptoms: a Gene-environment Interaction." Sleep, vol. 37, no. 2, 2014, pp. 351-8.
Watson NF, Harden KP, Buchwald D, et al. Sleep duration and depressive symptoms: a gene-environment interaction. Sleep. 2014;37(2):351-8.
Watson, N. F., Harden, K. P., Buchwald, D., Vitiello, M. V., Pack, A. I., Strachan, E., & Goldberg, J. (2014). Sleep duration and depressive symptoms: a gene-environment interaction. Sleep, 37(2), pp. 351-8. doi:10.5665/sleep.3412.
Watson NF, et al. Sleep Duration and Depressive Symptoms: a Gene-environment Interaction. Sleep. 2014 Feb 1;37(2):351-8. PubMed PMID: 24497663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep duration and depressive symptoms: a gene-environment interaction. AU - Watson,Nathaniel F, AU - Harden,Kathryn Paige, AU - Buchwald,Dedra, AU - Vitiello,Michael V, AU - Pack,Allan I, AU - Strachan,Eric, AU - Goldberg,Jack, Y1 - 2014/02/01/ PY - 2014/2/6/entrez PY - 2014/2/6/pubmed PY - 2014/11/18/medline KW - Depression KW - Dizygotic KW - Monozygotic KW - Sleep Duration KW - Symptoms KW - Twins SP - 351 EP - 8 JF - Sleep JO - Sleep VL - 37 IS - 2 N2 - OBJECTIVE: We used quantitative genetic models to assess whether sleep duration modifies genetic and environmental influences on depressive symptoms. METHOD: Participants were 1,788 adult twins from 894 same-sex twin pairs (192 male and 412 female monozygotic [MZ] pairs, and 81 male and 209 female dizygotic [DZ] pairs] from the University of Washington Twin Registry. Participants self-reported habitual sleep duration and depressive symptoms. Data were analyzed using quantitative genetic interaction models, which allowed the magnitude of additive genetic, shared environmental, and non-shared environmental influences on depressive symptoms to vary with sleep duration. RESULTS: Within MZ twin pairs, the twin who reported longer sleep duration reported fewer depressive symptoms (ec = -0.17, SE = 0.06, P < 0.05). There was a significant gene × sleep duration interaction effect on depressive symptoms (a'c = 0.23, SE = 0.08, P < 0.05), with the interaction occurring on genetic influences that are common to both sleep duration and depressive symptoms. Among individuals with sleep duration within the normal range (7-8.9 h/night), the total heritability (h2) of depressive symptoms was approximately 27%. However, among individuals with sleep duration within the low (< 7 h/night) or high (≥ 9 h/night) range, increased genetic influence on depressive symptoms was observed, particularly at sleep duration extremes (5 h/night: h2 = 53%; 10 h/night: h2 = 49%). CONCLUSION: Genetic contributions to depressive symptoms increase at both short and long sleep durations. SN - 1550-9109 UR - https://www.unboundmedicine.com/medline/citation/24497663/Sleep_duration_and_depressive_symptoms:_a_gene_environment_interaction_ L2 - https://academic.oup.com/sleep/article-lookup/doi/10.5665/sleep.3412 DB - PRIME DP - Unbound Medicine ER -