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Cranberry and recurrent cystitis: more than marketing?
Crit Rev Food Sci Nutr 2014; 54(8):1063-75CR

Abstract

Epidemiologic studies indicate that millions of people suffer from recurrent cystitis, a pathology requiring antibiotic prophylaxis and entailing high social costs. Cranberry is a traditional folk remedy for cystitis and, which, in the form of a variety of products and formulations has over several decades undergone extensive evaluation for the management of urinary tract infections (UTI). The aim of this retrospective study is to summarize and review the most relevant and recent preclinical and clinical studies on cranberries for the treatment of UTIs. The scientific literature selected for this review was identified by searches of Medline via PubMed. A variety of recent experimental evidence has shed light on the mechanism underlying the anti-adhesive properties of proanthrocyanidins, their structure-activity relationships, and pharmacokinetics. Analysis of clinical studies and evaluation of the cranberry efficacy/safety ratio in the prevention of UTIs strongly support the use of cranberry in the prophylaxis of recurrent UTIs in young and middle-aged women. However, evidence of its clinical use among other patients remains controversial.

Authors+Show Affiliations

a Department of Urology, University of Modena & Reggio Emilia , Modena , Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24499122

Citation

Micali, Salvatore, et al. "Cranberry and Recurrent Cystitis: More Than Marketing?" Critical Reviews in Food Science and Nutrition, vol. 54, no. 8, 2014, pp. 1063-75.
Micali S, Isgro G, Bianchi G, et al. Cranberry and recurrent cystitis: more than marketing? Crit Rev Food Sci Nutr. 2014;54(8):1063-75.
Micali, S., Isgro, G., Bianchi, G., Miceli, N., Calapai, G., & Navarra, M. (2014). Cranberry and recurrent cystitis: more than marketing? Critical Reviews in Food Science and Nutrition, 54(8), pp. 1063-75. doi:10.1080/10408398.2011.625574.
Micali S, et al. Cranberry and Recurrent Cystitis: More Than Marketing. Crit Rev Food Sci Nutr. 2014;54(8):1063-75. PubMed PMID: 24499122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry and recurrent cystitis: more than marketing? AU - Micali,Salvatore, AU - Isgro,Gianmarco, AU - Bianchi,Giampaolo, AU - Miceli,Natalizia, AU - Calapai,Gioacchino, AU - Navarra,Michele, PY - 2014/2/7/entrez PY - 2014/2/7/pubmed PY - 2014/9/30/medline SP - 1063 EP - 75 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 54 IS - 8 N2 - Epidemiologic studies indicate that millions of people suffer from recurrent cystitis, a pathology requiring antibiotic prophylaxis and entailing high social costs. Cranberry is a traditional folk remedy for cystitis and, which, in the form of a variety of products and formulations has over several decades undergone extensive evaluation for the management of urinary tract infections (UTI). The aim of this retrospective study is to summarize and review the most relevant and recent preclinical and clinical studies on cranberries for the treatment of UTIs. The scientific literature selected for this review was identified by searches of Medline via PubMed. A variety of recent experimental evidence has shed light on the mechanism underlying the anti-adhesive properties of proanthrocyanidins, their structure-activity relationships, and pharmacokinetics. Analysis of clinical studies and evaluation of the cranberry efficacy/safety ratio in the prevention of UTIs strongly support the use of cranberry in the prophylaxis of recurrent UTIs in young and middle-aged women. However, evidence of its clinical use among other patients remains controversial. SN - 1549-7852 UR - https://www.unboundmedicine.com/medline/citation/24499122/Cranberry_and_recurrent_cystitis:_more_than_marketing L2 - http://www.tandfonline.com/doi/full/10.1080/10408398.2011.625574 DB - PRIME DP - Unbound Medicine ER -