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Enantioselective palladium-catalyzed insertion of α-aryl-α-diazoacetates into the O-H bonds of phenols.
Angew Chem Int Ed Engl. 2014 Mar 10; 53(11):2978-81.AC

Abstract

A palladium-catalyzed asymmetric O-H insertion reaction was developed. Palladium complexes with chiral spiro bisoxazoline ligands promoted the insertion of α-aryl-α-diazoacetates into the O-H bond of phenols with high yield and excellent enantioselectivity under mild reaction conditions. This palladium-catalyzed asymmetric O-H insertion reaction provided an efficient and highly enantioselective method for the preparation of synthetically useful optically active α-aryl-α-aryloxyacetates.

Authors+Show Affiliations

State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24500845

Citation

Xie, Xiu-Lan, et al. "Enantioselective Palladium-catalyzed Insertion of Α-aryl-α-diazoacetates Into the O-H Bonds of Phenols." Angewandte Chemie (International Ed. in English), vol. 53, no. 11, 2014, pp. 2978-81.
Xie XL, Zhu SF, Guo JX, et al. Enantioselective palladium-catalyzed insertion of α-aryl-α-diazoacetates into the O-H bonds of phenols. Angew Chem Int Ed Engl. 2014;53(11):2978-81.
Xie, X. L., Zhu, S. F., Guo, J. X., Cai, Y., & Zhou, Q. L. (2014). Enantioselective palladium-catalyzed insertion of α-aryl-α-diazoacetates into the O-H bonds of phenols. Angewandte Chemie (International Ed. in English), 53(11), 2978-81. https://doi.org/10.1002/anie.201309820
Xie XL, et al. Enantioselective Palladium-catalyzed Insertion of Α-aryl-α-diazoacetates Into the O-H Bonds of Phenols. Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2978-81. PubMed PMID: 24500845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioselective palladium-catalyzed insertion of α-aryl-α-diazoacetates into the O-H bonds of phenols. AU - Xie,Xiu-Lan, AU - Zhu,Shou-Fei, AU - Guo,Jun-Xia, AU - Cai,Yan, AU - Zhou,Qi-Lin, Y1 - 2014/02/05/ PY - 2013/11/12/received PY - 2014/2/7/entrez PY - 2014/2/7/pubmed PY - 2014/2/7/medline KW - asymmetric catalysis KW - bisoxazoline ligands KW - carbenes KW - palladium KW - α-aryl-α-aryloxyacetates SP - 2978 EP - 81 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 53 IS - 11 N2 - A palladium-catalyzed asymmetric O-H insertion reaction was developed. Palladium complexes with chiral spiro bisoxazoline ligands promoted the insertion of α-aryl-α-diazoacetates into the O-H bond of phenols with high yield and excellent enantioselectivity under mild reaction conditions. This palladium-catalyzed asymmetric O-H insertion reaction provided an efficient and highly enantioselective method for the preparation of synthetically useful optically active α-aryl-α-aryloxyacetates. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/24500845/Enantioselective_palladium_catalyzed_insertion_of_α_aryl_α_diazoacetates_into_the_O_H_bonds_of_phenols_ L2 - https://doi.org/10.1002/anie.201309820 DB - PRIME DP - Unbound Medicine ER -
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