Tags

Type your tag names separated by a space and hit enter

Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney.
Hum Exp Toxicol. 2014 Nov; 33(11):1150-7.HE

Abstract

The aim of this study was to assess the potential subacute toxicity of zinc oxide (ZnO) nanoparticles (NPs) in Wistar rats in comparison with reference toxicant, zinc chloride (ZnCl2), of a non-nanoparticulate form. We therefore studied the relationships between zinc (Zn) accumulation, liver and kidney trace element levels, and plasmatic biochemical parameters. Rats in all groups were treated by intraperitoneal injection of ZnO NPs and/or ZnCl2 solution (25 mg/kg) every other day for 10 days. The contents of trace element in the liver and kidney were slightly modulated after ZnO NPs and/or ZnCl2 solution exposure. The same treatment increased the aspartate aminotransferase activity and uric acid concentration. However, ZnO NPs or ZnCl2 solution decreased the creatinine levels, whereas the combined intake of ZnO NPs and ZnCl2 decreased the glucose concentration. Interestingly, the analysis of the lyophilized powder of liver using the x-ray diffractometer showed the degradation of ZnO NPs in ZnO-treated group, instead there is a lack of NPs ZnO biosynthesis from the ZnCl2 solution injected in rats. These investigations suggest that combined injection of ZnO NPs and ZnCl2 solution has a possible toxic effect in rats. This effect could be related to Zn(2+) ion release and accumulation of this element in organs. Our findings provide crucial information that ZnO appeared to be absorbed in the organs in an ionic form rather than in a particulate form.

Authors+Show Affiliations

Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia amara_salem_fsb@yahoo.fr.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), College of Sciences, Department of Physics, Riyadh, Saudi Arabia Laboratory of Physics of Materials and Nanomaterials Applied at Environment, College of Sciences in Gabes, Zirig, Tunisia.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Jarzouna, Tunisia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24501101

Citation

Amara, S, et al. "Effects of Zinc Oxide Nanoparticles And/or Zinc Chloride On Biochemical Parameters and Mineral Levels in Rat Liver and Kidney." Human & Experimental Toxicology, vol. 33, no. 11, 2014, pp. 1150-7.
Amara S, Slama IB, Mrad I, et al. Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney. Hum Exp Toxicol. 2014;33(11):1150-7.
Amara, S., Slama, I. B., Mrad, I., Rihane, N., Khemissi, W., El Mir, L., Rhouma, K. B., Abdelmelek, H., & Sakly, M. (2014). Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney. Human & Experimental Toxicology, 33(11), 1150-7. https://doi.org/10.1177/0960327113510327
Amara S, et al. Effects of Zinc Oxide Nanoparticles And/or Zinc Chloride On Biochemical Parameters and Mineral Levels in Rat Liver and Kidney. Hum Exp Toxicol. 2014;33(11):1150-7. PubMed PMID: 24501101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney. AU - Amara,S, AU - Slama,I Ben, AU - Mrad,I, AU - Rihane,N, AU - Khemissi,W, AU - El Mir,L, AU - Rhouma,K Ben, AU - Abdelmelek,H, AU - Sakly,M, Y1 - 2014/02/05/ PY - 2014/2/7/entrez PY - 2014/2/7/pubmed PY - 2015/6/24/medline KW - ZnCl2 solution KW - ZnO nanoparticles KW - kidney KW - liver KW - rats KW - trace element SP - 1150 EP - 7 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 33 IS - 11 N2 - The aim of this study was to assess the potential subacute toxicity of zinc oxide (ZnO) nanoparticles (NPs) in Wistar rats in comparison with reference toxicant, zinc chloride (ZnCl2), of a non-nanoparticulate form. We therefore studied the relationships between zinc (Zn) accumulation, liver and kidney trace element levels, and plasmatic biochemical parameters. Rats in all groups were treated by intraperitoneal injection of ZnO NPs and/or ZnCl2 solution (25 mg/kg) every other day for 10 days. The contents of trace element in the liver and kidney were slightly modulated after ZnO NPs and/or ZnCl2 solution exposure. The same treatment increased the aspartate aminotransferase activity and uric acid concentration. However, ZnO NPs or ZnCl2 solution decreased the creatinine levels, whereas the combined intake of ZnO NPs and ZnCl2 decreased the glucose concentration. Interestingly, the analysis of the lyophilized powder of liver using the x-ray diffractometer showed the degradation of ZnO NPs in ZnO-treated group, instead there is a lack of NPs ZnO biosynthesis from the ZnCl2 solution injected in rats. These investigations suggest that combined injection of ZnO NPs and ZnCl2 solution has a possible toxic effect in rats. This effect could be related to Zn(2+) ion release and accumulation of this element in organs. Our findings provide crucial information that ZnO appeared to be absorbed in the organs in an ionic form rather than in a particulate form. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/24501101/Effects_of_zinc_oxide_nanoparticles_and/or_zinc_chloride_on_biochemical_parameters_and_mineral_levels_in_rat_liver_and_kidney_ L2 - https://journals.sagepub.com/doi/10.1177/0960327113510327?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -