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Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women.
Br J Nutr 2014; 111(9):1686-95BJ

Abstract

The protective effect of dietary carotenoid intake on the risk of breast cancer is inconclusive. Moreover, data on dietary carotenoids in relation to breast cancer in non-Western populations are scarce. The aim of the present study was to examine the association between dietary carotenoid intake and the risk of breast cancer among Chinese women. A total of 561 cases and 561 controls who were frequency matched by age (5-year interval) and residence were recruited in the present case-control study. Dietary intake information was collected by a face-to-face interview using a validated FFQ. The OR and 95 % CI were assessed by multivariate logistic regression after adjusting for various potential confounders. An inverse association was observed between the consumption of α-carotene, β-carotene, β-cryptoxanthin and lutein/zeaxanthin and the risk of breast cancer. The multivariate-adjusted OR for the highest quartile of intake compared with the lowest quartile of intake were 0·61 (95 % CI 0·43, 0·88) for α-carotene, 0·54 (95 % CI 0·38, 0·78) for β-carotene, 0·38 (95 % CI 0·26, 0·52) for β-cryptoxanthin and 0·49 (95 % CI 0·34, 0·71) for lutein/zeaxanthin. Lycopene intake was not found to be associated with the risk of breast cancer, with the adjusted OR of 0·89 (95 % CI 0·61, 1·30). These inverse associations were more evident among pre-menopausal women and women who were exposed to second-hand smoke. The protective effect of specific carotenoid intake was observed for all subtypes of hormone receptor status of breast cancer. The present study indicated that a greater intake of specific carotenoids was associated with a decreased risk of breast cancer among Chinese women residing in Guangdong.

Authors+Show Affiliations

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, People's Republic of China.Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, People's Republic of China.Department of Clinical Nutrition, Guangdong General Hospital (Guangdong Academy of Medical Sciences), Guangzhou, People's Republic of China.Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, People's Republic of China.Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, People's Republic of China.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24502868

Citation

Wang, Lian, et al. "Specific Carotenoid Intake Is Inversely Associated With the Risk of Breast Cancer Among Chinese Women." The British Journal of Nutrition, vol. 111, no. 9, 2014, pp. 1686-95.
Wang L, Li B, Pan MX, et al. Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women. Br J Nutr. 2014;111(9):1686-95.
Wang, L., Li, B., Pan, M. X., Mo, X. F., Chen, Y. M., & Zhang, C. X. (2014). Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women. The British Journal of Nutrition, 111(9), pp. 1686-95. doi:10.1017/S000711451300411X.
Wang L, et al. Specific Carotenoid Intake Is Inversely Associated With the Risk of Breast Cancer Among Chinese Women. Br J Nutr. 2014;111(9):1686-95. PubMed PMID: 24502868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women. AU - Wang,Lian, AU - Li,Bin, AU - Pan,Mei-Xia, AU - Mo,Xiong-Fei, AU - Chen,Yu-Ming, AU - Zhang,Cai-Xia, Y1 - 2014/02/06/ PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/6/3/medline SP - 1686 EP - 95 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 111 IS - 9 N2 - The protective effect of dietary carotenoid intake on the risk of breast cancer is inconclusive. Moreover, data on dietary carotenoids in relation to breast cancer in non-Western populations are scarce. The aim of the present study was to examine the association between dietary carotenoid intake and the risk of breast cancer among Chinese women. A total of 561 cases and 561 controls who were frequency matched by age (5-year interval) and residence were recruited in the present case-control study. Dietary intake information was collected by a face-to-face interview using a validated FFQ. The OR and 95 % CI were assessed by multivariate logistic regression after adjusting for various potential confounders. An inverse association was observed between the consumption of α-carotene, β-carotene, β-cryptoxanthin and lutein/zeaxanthin and the risk of breast cancer. The multivariate-adjusted OR for the highest quartile of intake compared with the lowest quartile of intake were 0·61 (95 % CI 0·43, 0·88) for α-carotene, 0·54 (95 % CI 0·38, 0·78) for β-carotene, 0·38 (95 % CI 0·26, 0·52) for β-cryptoxanthin and 0·49 (95 % CI 0·34, 0·71) for lutein/zeaxanthin. Lycopene intake was not found to be associated with the risk of breast cancer, with the adjusted OR of 0·89 (95 % CI 0·61, 1·30). These inverse associations were more evident among pre-menopausal women and women who were exposed to second-hand smoke. The protective effect of specific carotenoid intake was observed for all subtypes of hormone receptor status of breast cancer. The present study indicated that a greater intake of specific carotenoids was associated with a decreased risk of breast cancer among Chinese women residing in Guangdong. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/24502868/Specific_carotenoid_intake_is_inversely_associated_with_the_risk_of_breast_cancer_among_Chinese_women_ L2 - https://www.cambridge.org/core/product/identifier/S000711451300411X/type/journal_article DB - PRIME DP - Unbound Medicine ER -