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Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach.
Toxicol Lett. 2014 Oct 15; 230(2):85-103.TL

Abstract

The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. The role of pesticide exposure in neurodegenerative disease has long been suspected, but the specific causative agents and the mechanisms underlying are not fully understood. For the main neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis there are evidences linking their etiology with long-term/low-dose exposure to pesticides such as paraquat, maneb, dieldrin, pyrethroids and organophosphates. Most of these pesticides share common features, namely the ability to induce oxidative stress, mitochondrial dysfunction, α-synuclein fibrillization and neuronal cell loss. This review aims to clarify the role of pesticides as environmental risk factors in genesis of idiopathic PD and other neurological syndromes. For this purpose, the most relevant epidemiological and experimental data is highlighted in order to discuss the molecular mechanisms involved in neurodegeneration.

Authors+Show Affiliations

REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, Advanced Institute of Health Sciences-North (ISCS-N), CESPU, CRL, Gandra, Portugal. Electronic address: mteresabaltazar@gmail.com.REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, Advanced Institute of Health Sciences-North (ISCS-N), CESPU, CRL, Gandra, Portugal; Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; Forensic Sciences Center - CENCIFOR, Portugal.REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.Toxicology Department, Medical School, University of Crete, Heraklion, Crete, Greece.CIAFEL, Faculty of Sports, University of Porto, Porto, Portugal.REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address: felixdc@ff.up.pt.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24503016

Citation

Baltazar, Maria Teresa, et al. "Pesticides Exposure as Etiological Factors of Parkinson's Disease and Other Neurodegenerative Diseases--a Mechanistic Approach." Toxicology Letters, vol. 230, no. 2, 2014, pp. 85-103.
Baltazar MT, Dinis-Oliveira RJ, de Lourdes Bastos M, et al. Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach. Toxicol Lett. 2014;230(2):85-103.
Baltazar, M. T., Dinis-Oliveira, R. J., de Lourdes Bastos, M., Tsatsakis, A. M., Duarte, J. A., & Carvalho, F. (2014). Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach. Toxicology Letters, 230(2), 85-103. https://doi.org/10.1016/j.toxlet.2014.01.039
Baltazar MT, et al. Pesticides Exposure as Etiological Factors of Parkinson's Disease and Other Neurodegenerative Diseases--a Mechanistic Approach. Toxicol Lett. 2014 Oct 15;230(2):85-103. PubMed PMID: 24503016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach. AU - Baltazar,Maria Teresa, AU - Dinis-Oliveira,Ricardo Jorge, AU - de Lourdes Bastos,Maria, AU - Tsatsakis,Aristidis M, AU - Duarte,José Alberto, AU - Carvalho,Félix, Y1 - 2014/02/03/ PY - 2013/11/06/received PY - 2013/12/06/revised PY - 2014/01/27/accepted PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/12/15/medline KW - Alzheimer's disease KW - Amyotrophic lateral sclerosis KW - Neurodegenerative diseases KW - Paraquat KW - Parkinson's disease KW - Pesticides SP - 85 EP - 103 JF - Toxicology letters JO - Toxicol Lett VL - 230 IS - 2 N2 - The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. The role of pesticide exposure in neurodegenerative disease has long been suspected, but the specific causative agents and the mechanisms underlying are not fully understood. For the main neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis there are evidences linking their etiology with long-term/low-dose exposure to pesticides such as paraquat, maneb, dieldrin, pyrethroids and organophosphates. Most of these pesticides share common features, namely the ability to induce oxidative stress, mitochondrial dysfunction, α-synuclein fibrillization and neuronal cell loss. This review aims to clarify the role of pesticides as environmental risk factors in genesis of idiopathic PD and other neurological syndromes. For this purpose, the most relevant epidemiological and experimental data is highlighted in order to discuss the molecular mechanisms involved in neurodegeneration. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/24503016/Pesticides_exposure_as_etiological_factors_of_Parkinson's_disease_and_other_neurodegenerative_diseases__a_mechanistic_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(14)00059-9 DB - PRIME DP - Unbound Medicine ER -