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Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats.
Behav Brain Res. 2014 May 01; 264:9-16.BB

Abstract

Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in specific brain proteins. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring serum corticosterone levels and the content of brain derived neurotrophic factor (BDNF) in the hippocampus and amygdala of rats exposed to the chronic unpredictable mild stress (CUMS). Male Wistar rats were subjected to the CUMS protocol for a period of 5 weeks to induce depressive-like behavior. Resveratrol treatment (20, 40 and 80mg/kg/i.p. 5 weeks) significantly reversed the CUMS-induced behavioral abnormalities (reduced sucrose preference, increased immobility time and decreased locomotor activity) and the elevated serum corticosterone levels observed in stressed rats. Additionally, 5-weeks of CUMS exposure significantly decreased BDNF levels in the hippocampus and amygdala, and was accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB), while resveratrol treatment normalized these levels. All of these effects of resveratrol were essentially identical to that observed with the established antidepressant, desipramine. In conclusion, our study shows that resveratrol exerted antidepressant-like effects in CUMS rats, mediated in part by normalizing serum corticosterone levels while up-regulating pERK, pCREB and BDNF levels in the hippocampus and amygdala.

Authors+Show Affiliations

Department of Medical Psychology, Shandong University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology, Shandong University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Histology and Embryology of Taishan Medical University, Taian, Shandong 271000, PR China.Institute of Bioscience, Luoyang Normal University, 71 no., Longmen Road, Luoyang, Henan 471022, PR China; Department of Medical Psychology, Shandong University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44 no., Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: wangzhen@sdu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24503118

Citation

Liu, Dexiang, et al. "Resveratrol Reverses the Effects of Chronic Unpredictable Mild Stress On Behavior, Serum Corticosterone Levels and BDNF Expression in Rats." Behavioural Brain Research, vol. 264, 2014, pp. 9-16.
Liu D, Xie K, Yang X, et al. Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behav Brain Res. 2014;264:9-16.
Liu, D., Xie, K., Yang, X., Gu, J., Ge, L., Wang, X., & Wang, Z. (2014). Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behavioural Brain Research, 264, 9-16. https://doi.org/10.1016/j.bbr.2014.01.039
Liu D, et al. Resveratrol Reverses the Effects of Chronic Unpredictable Mild Stress On Behavior, Serum Corticosterone Levels and BDNF Expression in Rats. Behav Brain Res. 2014 May 1;264:9-16. PubMed PMID: 24503118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. AU - Liu,Dexiang, AU - Xie,Kai, AU - Yang,Xudong, AU - Gu,Jianhua, AU - Ge,Li, AU - Wang,Xueer, AU - Wang,Zhen, Y1 - 2014/02/04/ PY - 2013/09/22/received PY - 2014/01/02/revised PY - 2014/01/28/accepted PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/11/6/medline KW - Chronic unpredictable mild stress (CUMS) KW - Resveratrol KW - brain derived neurotrophic factor (BDNF) KW - hypothalamic–pituitary–adrenal (HPA) SP - 9 EP - 16 JF - Behavioural brain research JO - Behav. Brain Res. VL - 264 N2 - Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in specific brain proteins. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring serum corticosterone levels and the content of brain derived neurotrophic factor (BDNF) in the hippocampus and amygdala of rats exposed to the chronic unpredictable mild stress (CUMS). Male Wistar rats were subjected to the CUMS protocol for a period of 5 weeks to induce depressive-like behavior. Resveratrol treatment (20, 40 and 80mg/kg/i.p. 5 weeks) significantly reversed the CUMS-induced behavioral abnormalities (reduced sucrose preference, increased immobility time and decreased locomotor activity) and the elevated serum corticosterone levels observed in stressed rats. Additionally, 5-weeks of CUMS exposure significantly decreased BDNF levels in the hippocampus and amygdala, and was accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB), while resveratrol treatment normalized these levels. All of these effects of resveratrol were essentially identical to that observed with the established antidepressant, desipramine. In conclusion, our study shows that resveratrol exerted antidepressant-like effects in CUMS rats, mediated in part by normalizing serum corticosterone levels while up-regulating pERK, pCREB and BDNF levels in the hippocampus and amygdala. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/24503118/Resveratrol_reverses_the_effects_of_chronic_unpredictable_mild_stress_on_behavior_serum_corticosterone_levels_and_BDNF_expression_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(14)00053-9 DB - PRIME DP - Unbound Medicine ER -