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[Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China].
Zhonghua Jie He He Hu Xi Za Zhi. 2013 Dec; 36(12):954-8.ZJ

Abstract

OBJECTIVE

To explore the tendency of macrolide resistance in Mycoplasma pneumoniae infection in community-acquired pneumonia (CAP) patients in Beijing.

METHODS

Adult CAP patients of ≥ 18 yrs were enrolled in 3 medical centers in Beijing , China. Throat swab samples were taken from all the patients to perform the culture of M. pneumoniae . All the isolated M. pneumoniae strains were subjected to susceptibility evaluation for 6 agents, including macrolides such as erythromycin and azithromycin. In strains showing macrolide resistance, the 23S rRNA gene was analyzed.

RESULTS

A total 53 strains of M. pneumoniae were isolated from 321 enrolled patients. Thirty-eight of the isolated strains (71.7%) were resistant to erythromycin and 32 of them (60.4%) were resistant to azithromycin. Six strains with moderate or low level of erythromycin-resistance were still susceptible to azithromycin. No fluoroquinolone-resistant or tetracycline-resistant strains were observed in our study. Point transition of A2063G in the 23S ribosomal RNA gene was the main reason for the high prevalence of macrolide resistance.

CONCLUSIONS

The prevalence of macrolide resistance in M. pneumoniae is very high in adult CAP patients in Beijing. Studies are needed to clarify the clinical meaning of prevalence of macrolide-resistant M. pneumoniae in adults CAP patients.

Authors+Show Affiliations

Department of Infectious Diseases and Clinical Microbiology and Beijing Institute of Respiratory Medicine, Beijing Chao yang Hospital, Capital Medical University, Beijing 100020, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableEmail: liuyn@301hospital.com.cn.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

24503430

Citation

Yin, Yu-dong, et al. "[Survey of Macrolide Resistance in Mycoplasma Pneumoniae in Adult Patients With Community-acquired Pneumonia in Beijing, China]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 36, no. 12, 2013, pp. 954-8.
Yin YD, Cao B, Wang H, et al. [Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China]. Zhonghua Jie He He Hu Xi Za Zhi. 2013;36(12):954-8.
Yin, Y. D., Cao, B., Wang, H., Wang, R. T., Liu, Y. M., Gao, Y., Qu, J. X., Han, G. J., & Liu, Y. N. (2013). [Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 36(12), 954-8.
Yin YD, et al. [Survey of Macrolide Resistance in Mycoplasma Pneumoniae in Adult Patients With Community-acquired Pneumonia in Beijing, China]. Zhonghua Jie He He Hu Xi Za Zhi. 2013;36(12):954-8. PubMed PMID: 24503430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Survey of macrolide resistance in Mycoplasma pneumoniae in adult patients with community-acquired pneumonia in Beijing, China]. AU - Yin,Yu-dong, AU - Cao,Bin, AU - Wang,Hui, AU - Wang,Ren-tao, AU - Liu,Ying-mei, AU - Gao,Yan, AU - Qu,Jiu-xin, AU - Han,Guo-jing, AU - Liu,You-ning, PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/10/1/medline SP - 954 EP - 8 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 36 IS - 12 N2 - OBJECTIVE: To explore the tendency of macrolide resistance in Mycoplasma pneumoniae infection in community-acquired pneumonia (CAP) patients in Beijing. METHODS: Adult CAP patients of ≥ 18 yrs were enrolled in 3 medical centers in Beijing , China. Throat swab samples were taken from all the patients to perform the culture of M. pneumoniae . All the isolated M. pneumoniae strains were subjected to susceptibility evaluation for 6 agents, including macrolides such as erythromycin and azithromycin. In strains showing macrolide resistance, the 23S rRNA gene was analyzed. RESULTS: A total 53 strains of M. pneumoniae were isolated from 321 enrolled patients. Thirty-eight of the isolated strains (71.7%) were resistant to erythromycin and 32 of them (60.4%) were resistant to azithromycin. Six strains with moderate or low level of erythromycin-resistance were still susceptible to azithromycin. No fluoroquinolone-resistant or tetracycline-resistant strains were observed in our study. Point transition of A2063G in the 23S ribosomal RNA gene was the main reason for the high prevalence of macrolide resistance. CONCLUSIONS: The prevalence of macrolide resistance in M. pneumoniae is very high in adult CAP patients in Beijing. Studies are needed to clarify the clinical meaning of prevalence of macrolide-resistant M. pneumoniae in adults CAP patients. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/24503430/[Survey_of_macrolide_resistance_in_Mycoplasma_pneumoniae_in_adult_patients_with_community_acquired_pneumonia_in_Beijing_China]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1001-0939&year=2013&vol=36&issue=12&fpage=954 DB - PRIME DP - Unbound Medicine ER -