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Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?

Abstract

OBJECTIVE

Stress can play an important role in etiology of fibromyalgia syndrome (FMS) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. The current study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase), and immune (IgA) systems in women with FMS.

METHODS

Seventy-six women with FMS diagnosed according to the American College of Rheumatology criteria participated in the study. Salivary cortisol, α-amylase activity, salivary flow rate, and IgA concentration were collected from nonstimulated saliva. A numerical pain rate scale (0 to 10) was used to assess the intensity of pain, whereas functional ability was determined using the Fibromyalgia Impact Questionnaire (FIQ). After amplifying Val158Met polymorphisms by polymerase chain reaction, 3 COMT genotypes were considered: Val/Val, Val/Met, and Met/Met.

RESULTS

Women with FMS with the Met/Met genotype reported higher α-amylase activity, lower salivary flow rate, and lower IgA concentration than those women with FMS carrying the Val/Met (P<0.05) or Val/Val (P<0.01) genotypes. No difference in cortisol concentration (P>0.70) was found. These results were not associated with the intensity of pain, disability, and medication intake.

CONCLUSIONS

The results suggest that women with FMS with the Met/Met genotype exhibit greater disturbed activity of the SNS and humoral immune system. These results provide initial evidence of a link between Val158Met polymorphism and dysfunctions in the SNS and humoral immune system in women with FMS.

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  • Authors+Show Affiliations

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    *Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine †Esthesiology Laboratory ‡Department of Psychology, Universidad Rey Juan Carlos, Alcorcón §Department of Nursing, Health Sciences Faculty ∥Department of Pharmaceutical Chemistry and Organic Chemistry, School of Pharmacy ¶Department of Physical Therapy, Health Sciences Faculty, Universidad de Granada, Granada, Spain.

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    Source

    The Clinical journal of pain 30:3 2014 Mar pg 199-204

    MeSH

    Catechol O-Methyltransferase
    Female
    Fibromyalgia
    Genetic Predisposition to Disease
    Genotype
    Genotyping Techniques
    Humans
    Hydrocortisone
    Immunoglobulin A, Secretory
    Middle Aged
    Pain Measurement
    Polymerase Chain Reaction
    Polymorphism, Genetic
    Saliva
    Severity of Illness Index
    Surveys and Questionnaires
    alpha-Amylases

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24503977

    Citation

    Fernández-de-las-Peñas, César, et al. "Has catechol-O-methyltransferase Genotype (Val158Met) an Influence On Endocrine, Sympathetic Nervous and Humoral Immune Systems in Women With Fibromyalgia Syndrome?" The Clinical Journal of Pain, vol. 30, no. 3, 2014, pp. 199-204.
    Fernández-de-las-Peñas C, Peñacoba-Puente C, Cigarán-Méndez M, et al. Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? Clin J Pain. 2014;30(3):199-204.
    Fernández-de-las-Peñas, C., Peñacoba-Puente, C., Cigarán-Méndez, M., Díaz-Rodríguez, L., Rubio-Ruiz, B., & Arroyo-Morales, M. (2014). Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? The Clinical Journal of Pain, 30(3), pp. 199-204. doi:10.1097/AJP.0b013e3182928da0.
    Fernández-de-las-Peñas C, et al. Has catechol-O-methyltransferase Genotype (Val158Met) an Influence On Endocrine, Sympathetic Nervous and Humoral Immune Systems in Women With Fibromyalgia Syndrome. Clin J Pain. 2014;30(3):199-204. PubMed PMID: 24503977.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? AU - Fernández-de-las-Peñas,César, AU - Peñacoba-Puente,Cecilia, AU - Cigarán-Méndez,Margarita, AU - Díaz-Rodríguez,Lourdes, AU - Rubio-Ruiz,Belén, AU - Arroyo-Morales,Manuel, PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/10/17/medline SP - 199 EP - 204 JF - The Clinical journal of pain JO - Clin J Pain VL - 30 IS - 3 N2 - OBJECTIVE: Stress can play an important role in etiology of fibromyalgia syndrome (FMS) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. The current study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase), and immune (IgA) systems in women with FMS. METHODS: Seventy-six women with FMS diagnosed according to the American College of Rheumatology criteria participated in the study. Salivary cortisol, α-amylase activity, salivary flow rate, and IgA concentration were collected from nonstimulated saliva. A numerical pain rate scale (0 to 10) was used to assess the intensity of pain, whereas functional ability was determined using the Fibromyalgia Impact Questionnaire (FIQ). After amplifying Val158Met polymorphisms by polymerase chain reaction, 3 COMT genotypes were considered: Val/Val, Val/Met, and Met/Met. RESULTS: Women with FMS with the Met/Met genotype reported higher α-amylase activity, lower salivary flow rate, and lower IgA concentration than those women with FMS carrying the Val/Met (P<0.05) or Val/Val (P<0.01) genotypes. No difference in cortisol concentration (P>0.70) was found. These results were not associated with the intensity of pain, disability, and medication intake. CONCLUSIONS: The results suggest that women with FMS with the Met/Met genotype exhibit greater disturbed activity of the SNS and humoral immune system. These results provide initial evidence of a link between Val158Met polymorphism and dysfunctions in the SNS and humoral immune system in women with FMS. SN - 1536-5409 UR - https://www.unboundmedicine.com/medline/citation/24503977/Has_catechol_O_methyltransferase_genotype__Val158Met__an_influence_on_endocrine_sympathetic_nervous_and_humoral_immune_systems_in_women_with_fibromyalgia_syndrome L2 - http://Insights.ovid.com/pubmed?pmid=24503977 DB - PRIME DP - Unbound Medicine ER -