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Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?
Clin J Pain 2014; 30(3):199-204CJ

Abstract

OBJECTIVE

Stress can play an important role in etiology of fibromyalgia syndrome (FMS) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. The current study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase), and immune (IgA) systems in women with FMS.

METHODS

Seventy-six women with FMS diagnosed according to the American College of Rheumatology criteria participated in the study. Salivary cortisol, α-amylase activity, salivary flow rate, and IgA concentration were collected from nonstimulated saliva. A numerical pain rate scale (0 to 10) was used to assess the intensity of pain, whereas functional ability was determined using the Fibromyalgia Impact Questionnaire (FIQ). After amplifying Val158Met polymorphisms by polymerase chain reaction, 3 COMT genotypes were considered: Val/Val, Val/Met, and Met/Met.

RESULTS

Women with FMS with the Met/Met genotype reported higher α-amylase activity, lower salivary flow rate, and lower IgA concentration than those women with FMS carrying the Val/Met (P<0.05) or Val/Val (P<0.01) genotypes. No difference in cortisol concentration (P>0.70) was found. These results were not associated with the intensity of pain, disability, and medication intake.

CONCLUSIONS

The results suggest that women with FMS with the Met/Met genotype exhibit greater disturbed activity of the SNS and humoral immune system. These results provide initial evidence of a link between Val158Met polymorphism and dysfunctions in the SNS and humoral immune system in women with FMS.

Authors+Show Affiliations

*Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine †Esthesiology Laboratory ‡Department of Psychology, Universidad Rey Juan Carlos, Alcorcón §Department of Nursing, Health Sciences Faculty ∥Department of Pharmaceutical Chemistry and Organic Chemistry, School of Pharmacy ¶Department of Physical Therapy, Health Sciences Faculty, Universidad de Granada, Granada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24503977

Citation

Fernández-de-las-Peñas, César, et al. "Has catechol-O-methyltransferase Genotype (Val158Met) an Influence On Endocrine, Sympathetic Nervous and Humoral Immune Systems in Women With Fibromyalgia Syndrome?" The Clinical Journal of Pain, vol. 30, no. 3, 2014, pp. 199-204.
Fernández-de-las-Peñas C, Peñacoba-Puente C, Cigarán-Méndez M, et al. Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? Clin J Pain. 2014;30(3):199-204.
Fernández-de-las-Peñas, C., Peñacoba-Puente, C., Cigarán-Méndez, M., Díaz-Rodríguez, L., Rubio-Ruiz, B., & Arroyo-Morales, M. (2014). Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? The Clinical Journal of Pain, 30(3), pp. 199-204. doi:10.1097/AJP.0b013e3182928da0.
Fernández-de-las-Peñas C, et al. Has catechol-O-methyltransferase Genotype (Val158Met) an Influence On Endocrine, Sympathetic Nervous and Humoral Immune Systems in Women With Fibromyalgia Syndrome. Clin J Pain. 2014;30(3):199-204. PubMed PMID: 24503977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? AU - Fernández-de-las-Peñas,César, AU - Peñacoba-Puente,Cecilia, AU - Cigarán-Méndez,Margarita, AU - Díaz-Rodríguez,Lourdes, AU - Rubio-Ruiz,Belén, AU - Arroyo-Morales,Manuel, PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/10/17/medline SP - 199 EP - 204 JF - The Clinical journal of pain JO - Clin J Pain VL - 30 IS - 3 N2 - OBJECTIVE: Stress can play an important role in etiology of fibromyalgia syndrome (FMS) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. The current study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase), and immune (IgA) systems in women with FMS. METHODS: Seventy-six women with FMS diagnosed according to the American College of Rheumatology criteria participated in the study. Salivary cortisol, α-amylase activity, salivary flow rate, and IgA concentration were collected from nonstimulated saliva. A numerical pain rate scale (0 to 10) was used to assess the intensity of pain, whereas functional ability was determined using the Fibromyalgia Impact Questionnaire (FIQ). After amplifying Val158Met polymorphisms by polymerase chain reaction, 3 COMT genotypes were considered: Val/Val, Val/Met, and Met/Met. RESULTS: Women with FMS with the Met/Met genotype reported higher α-amylase activity, lower salivary flow rate, and lower IgA concentration than those women with FMS carrying the Val/Met (P<0.05) or Val/Val (P<0.01) genotypes. No difference in cortisol concentration (P>0.70) was found. These results were not associated with the intensity of pain, disability, and medication intake. CONCLUSIONS: The results suggest that women with FMS with the Met/Met genotype exhibit greater disturbed activity of the SNS and humoral immune system. These results provide initial evidence of a link between Val158Met polymorphism and dysfunctions in the SNS and humoral immune system in women with FMS. SN - 1536-5409 UR - https://www.unboundmedicine.com/medline/citation/24503977/Has_catechol_O_methyltransferase_genotype__Val158Met__an_influence_on_endocrine_sympathetic_nervous_and_humoral_immune_systems_in_women_with_fibromyalgia_syndrome L2 - http://Insights.ovid.com/pubmed?pmid=24503977 DB - PRIME DP - Unbound Medicine ER -