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Tea consumption and leukemia risk: a meta-analysis.

Abstract

Epidemiologic findings concerning the association between tea consumption and leukemia risk yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. One cohort studies and six case-control studies with 1,019 cases were identified using PubMed, Web of Science, and EMBASE. We computed summary relative risks (RRs) and 95 % confidence intervals (CIs) using random effect model applied to the relative risk associated with ever, moderate, or highest drinkers vs. non/lowest drinkers. Subgroup analyses were performed based on country (China and USA). Compared with non/lowest drinkers, the combined RR for ever drinkers was 0.76 (95 % CI=0.65-0.89). In subgroup analyses, significant inverse associations were found for both China and USA studies. The summary RR was 0.57 (95 % CI=0.41-0.78) for highest drinkers. Same results were only found in China studies. No significant associations were found for moderate drinkers in overall analysis or in subgroup analyses. There was some evidence of publication bias. In conclusion, this meta-analysis suggests a significant inverse association of high tea consumption and leukemia risk. Results should be interpreted cautiously given the potential publication bias.

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  • Authors+Show Affiliations

    ,

    Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Baiziting 42, Nanjing, 210009, China.

    , , , , ,

    Source

    MeSH

    Catechin
    Humans
    Leukemia
    Publication Bias
    Risk
    Tea

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24504676

    Citation

    Zhong, Shanliang, et al. "Tea Consumption and Leukemia Risk: a Meta-analysis." Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 35, no. 6, 2014, pp. 5205-12.
    Zhong S, Chen Z, Yu X, et al. Tea consumption and leukemia risk: a meta-analysis. Tumour Biol. 2014;35(6):5205-12.
    Zhong, S., Chen, Z., Yu, X., Chen, W., Lv, M., Ma, T., & Zhao, J. (2014). Tea consumption and leukemia risk: a meta-analysis. Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 35(6), pp. 5205-12. doi:10.1007/s13277-014-1675-9.
    Zhong S, et al. Tea Consumption and Leukemia Risk: a Meta-analysis. Tumour Biol. 2014;35(6):5205-12. PubMed PMID: 24504676.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Tea consumption and leukemia risk: a meta-analysis. AU - Zhong,Shanliang, AU - Chen,Zhiyuan, AU - Yu,Xinnian, AU - Chen,Weixian, AU - Lv,Mengmeng, AU - Ma,Tengfei, AU - Zhao,Jianhua, Y1 - 2014/02/07/ PY - 2013/11/12/received PY - 2014/01/22/accepted PY - 2014/2/8/entrez PY - 2014/2/8/pubmed PY - 2014/8/20/medline SP - 5205 EP - 12 JF - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine JO - Tumour Biol. VL - 35 IS - 6 N2 - Epidemiologic findings concerning the association between tea consumption and leukemia risk yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. One cohort studies and six case-control studies with 1,019 cases were identified using PubMed, Web of Science, and EMBASE. We computed summary relative risks (RRs) and 95 % confidence intervals (CIs) using random effect model applied to the relative risk associated with ever, moderate, or highest drinkers vs. non/lowest drinkers. Subgroup analyses were performed based on country (China and USA). Compared with non/lowest drinkers, the combined RR for ever drinkers was 0.76 (95 % CI=0.65-0.89). In subgroup analyses, significant inverse associations were found for both China and USA studies. The summary RR was 0.57 (95 % CI=0.41-0.78) for highest drinkers. Same results were only found in China studies. No significant associations were found for moderate drinkers in overall analysis or in subgroup analyses. There was some evidence of publication bias. In conclusion, this meta-analysis suggests a significant inverse association of high tea consumption and leukemia risk. Results should be interpreted cautiously given the potential publication bias. SN - 1423-0380 UR - https://www.unboundmedicine.com/medline/citation/24504676/full_citation L2 - https://link.springer.com/article/10.1007/s13277-014-1675-9 DB - PRIME DP - Unbound Medicine ER -