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R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease.
Vet J. 2014 Mar; 199(3):348-54.VJ

Abstract

Mitral regurgitation (MR) due to myxomatous mitral valve disease (MMVD) is a frequent finding in Cavalier King Charles Spaniels (CKCSs). Sinus arrhythmia and atrial premature complexes leading to R-R interval variations occur in dogs. The aim of the study was to evaluate whether the duration of the R-R interval immediately influences the degree of MR assessed by echocardiography in dogs. Clinical examination including echocardiography was performed in 103 privately-owned dogs: 16 control Beagles, 70 CKCSs with different degree of MR and 17 dogs of different breeds with clinical signs of congestive heart failure due to MMVD. The severity of MR was evaluated in apical four-chamber view using colour Doppler flow mapping (maximum % of the left atrium area) and colour Doppler M-mode (duration in ms). The influence of the ratio between present and preceding R-R interval on MR severity was evaluated in 10 consecutive R-R intervals using a linear mixed model for repeated measurements. MR severity was increased when a short R-R interval was followed by a long R-R interval in CKCSs with different degrees of MR (P<0.005 when adjusted for multiple testing). The relationship was not significant in control dogs with minimal MR and in dogs with severe MR and clinical signs of heart failure. In conclusion, MR severity increases in long R-R intervals when these follow a short R-R interval in CKCSs with different degrees of MR due to asymptomatic MMVD. Thus, R-R interval variations may affect the echocardiographic grading of MR in CKCSs.

Authors+Show Affiliations

Department of Veterinary Disease Biology, University of Copenhagen, Ridebanevej 9, 1870 Frederiksberg, Denmark.Department of Cardiology, Odense University Hospital, Sønder Boulevard, 5000 Odense C, Denmark.Department of Clinical Sciences, Swedish University of Agricultural Sciences, 7054, 750-07 Uppsala, Sweden.Laboratory of Applied Statistics, Department of Mathematical Sciences, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.Department of Veterinary Disease Biology, University of Copenhagen, Ridebanevej 9, 1870 Frederiksberg, Denmark.Department of Veterinary Disease Biology, University of Copenhagen, Ridebanevej 9, 1870 Frederiksberg, Denmark.Department of Veterinary Disease Biology, University of Copenhagen, Ridebanevej 9, 1870 Frederiksberg, Denmark. Electronic address: lihol@sund.ku.dk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24507881

Citation

Reimann, M J., et al. "R-R Interval Variations Influence the Degree of Mitral Regurgitation in Dogs With Myxomatous Mitral Valve Disease." Veterinary Journal (London, England : 1997), vol. 199, no. 3, 2014, pp. 348-54.
Reimann MJ, Møller JE, Häggström J, et al. R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease. Vet J. 2014;199(3):348-54.
Reimann, M. J., Møller, J. E., Häggström, J., Markussen, B., Holen, A. E., Falk, T., & Olsen, L. H. (2014). R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease. Veterinary Journal (London, England : 1997), 199(3), 348-54. https://doi.org/10.1016/j.tvjl.2014.01.001
Reimann MJ, et al. R-R Interval Variations Influence the Degree of Mitral Regurgitation in Dogs With Myxomatous Mitral Valve Disease. Vet J. 2014;199(3):348-54. PubMed PMID: 24507881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease. AU - Reimann,M J, AU - Møller,J E, AU - Häggström,J, AU - Markussen,B, AU - Holen,A E W, AU - Falk,T, AU - Olsen,L H, Y1 - 2014/01/11/ PY - 2013/07/31/received PY - 2013/12/19/revised PY - 2014/01/03/accepted PY - 2014/2/11/entrez PY - 2014/2/11/pubmed PY - 2015/4/7/medline KW - Animal model KW - Cavalier King Charles Spaniel KW - Mitral regurgitation KW - R-R interval variations KW - Sinus arrhythmia SP - 348 EP - 54 JF - Veterinary journal (London, England : 1997) JO - Vet. J. VL - 199 IS - 3 N2 - Mitral regurgitation (MR) due to myxomatous mitral valve disease (MMVD) is a frequent finding in Cavalier King Charles Spaniels (CKCSs). Sinus arrhythmia and atrial premature complexes leading to R-R interval variations occur in dogs. The aim of the study was to evaluate whether the duration of the R-R interval immediately influences the degree of MR assessed by echocardiography in dogs. Clinical examination including echocardiography was performed in 103 privately-owned dogs: 16 control Beagles, 70 CKCSs with different degree of MR and 17 dogs of different breeds with clinical signs of congestive heart failure due to MMVD. The severity of MR was evaluated in apical four-chamber view using colour Doppler flow mapping (maximum % of the left atrium area) and colour Doppler M-mode (duration in ms). The influence of the ratio between present and preceding R-R interval on MR severity was evaluated in 10 consecutive R-R intervals using a linear mixed model for repeated measurements. MR severity was increased when a short R-R interval was followed by a long R-R interval in CKCSs with different degrees of MR (P<0.005 when adjusted for multiple testing). The relationship was not significant in control dogs with minimal MR and in dogs with severe MR and clinical signs of heart failure. In conclusion, MR severity increases in long R-R intervals when these follow a short R-R interval in CKCSs with different degrees of MR due to asymptomatic MMVD. Thus, R-R interval variations may affect the echocardiographic grading of MR in CKCSs. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/24507881/R_R_interval_variations_influence_the_degree_of_mitral_regurgitation_in_dogs_with_myxomatous_mitral_valve_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(14)00004-5 DB - PRIME DP - Unbound Medicine ER -