Tags

Type your tag names separated by a space and hit enter

Detection of clinically relevant pain relief in cats with degenerative joint disease associated pain.
J Vet Intern Med 2014 Mar-Apr; 28(2):346-50JV

Abstract

BACKGROUND

Detection of clinically relevant pain relief in cats with degenerative joint disease (DJD) is complicated by a lack of validated outcome measures and a placebo effect.

HYPOTHESIS/OBJECTIVES

To evaluate a novel approach for detection of pain relief in cats with DJD.

ANIMALS

Fifty-eight client-owned cats.

METHODS

Prospective, double-masked, placebo-controlled, stratified, randomized, clinical study. Enrolled cats were 6-21 years of age, with owner-observed mobility impairment, evidence of pain in at least 2 joints during orthopedic examination, and overlapping radiographic evidence of DJD, and underwent a 2-week baseline period, 3-week treatment period with placebo or meloxicam, and 3-week masked washout period. Outcome measures were evaluated at days 0, 15, 36, and 57.

RESULTS

Both groups significantly improved after the treatment period (day 36) on client-specific outcome measures (CSOM) and feline musculoskeletal pain index (FMPI) (P < .0001 for both); there was no difference between the groups on CSOM or FMPI score improvement. After the masked washout period, more cats that received meloxicam during the treatment period had a clinically relevant decrease in CSOM score (P = .048) and FMPI score (P = .021) than cats that received placebo.

CONCLUSIONS AND CLINICAL IMPORTANCE

Using both a client-specific and a general clinical metrology instrument, owners of cats with DJD were able to detect evident recurrence of clinical signs after withdrawal of active medication than after withdrawal of placebo, and that this study design might be a novel and useful way to circumvent the placebo effect and detect the efficacy of pain-relieving medications.

Authors+Show Affiliations

Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Raleigh, NC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24512390

Citation

Gruen, M E., et al. "Detection of Clinically Relevant Pain Relief in Cats With Degenerative Joint Disease Associated Pain." Journal of Veterinary Internal Medicine, vol. 28, no. 2, 2014, pp. 346-50.
Gruen ME, Griffith E, Thomson A, et al. Detection of clinically relevant pain relief in cats with degenerative joint disease associated pain. J Vet Intern Med. 2014;28(2):346-50.
Gruen, M. E., Griffith, E., Thomson, A., Simpson, W., & Lascelles, B. D. (2014). Detection of clinically relevant pain relief in cats with degenerative joint disease associated pain. Journal of Veterinary Internal Medicine, 28(2), pp. 346-50. doi:10.1111/jvim.12312.
Gruen ME, et al. Detection of Clinically Relevant Pain Relief in Cats With Degenerative Joint Disease Associated Pain. J Vet Intern Med. 2014;28(2):346-50. PubMed PMID: 24512390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of clinically relevant pain relief in cats with degenerative joint disease associated pain. AU - Gruen,M E, AU - Griffith,E, AU - Thomson,A, AU - Simpson,W, AU - Lascelles,B D X, Y1 - 2014/02/10/ PY - 2013/08/26/received PY - 2013/11/20/revised PY - 2013/12/26/accepted PY - 2014/2/12/entrez PY - 2014/2/12/pubmed PY - 2015/2/20/medline KW - Client-specific outcome measures KW - Degenerative joint disease KW - Osteoarthritis SP - 346 EP - 50 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 28 IS - 2 N2 - BACKGROUND: Detection of clinically relevant pain relief in cats with degenerative joint disease (DJD) is complicated by a lack of validated outcome measures and a placebo effect. HYPOTHESIS/OBJECTIVES: To evaluate a novel approach for detection of pain relief in cats with DJD. ANIMALS: Fifty-eight client-owned cats. METHODS: Prospective, double-masked, placebo-controlled, stratified, randomized, clinical study. Enrolled cats were 6-21 years of age, with owner-observed mobility impairment, evidence of pain in at least 2 joints during orthopedic examination, and overlapping radiographic evidence of DJD, and underwent a 2-week baseline period, 3-week treatment period with placebo or meloxicam, and 3-week masked washout period. Outcome measures were evaluated at days 0, 15, 36, and 57. RESULTS: Both groups significantly improved after the treatment period (day 36) on client-specific outcome measures (CSOM) and feline musculoskeletal pain index (FMPI) (P < .0001 for both); there was no difference between the groups on CSOM or FMPI score improvement. After the masked washout period, more cats that received meloxicam during the treatment period had a clinically relevant decrease in CSOM score (P = .048) and FMPI score (P = .021) than cats that received placebo. CONCLUSIONS AND CLINICAL IMPORTANCE: Using both a client-specific and a general clinical metrology instrument, owners of cats with DJD were able to detect evident recurrence of clinical signs after withdrawal of active medication than after withdrawal of placebo, and that this study design might be a novel and useful way to circumvent the placebo effect and detect the efficacy of pain-relieving medications. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/24512390/Detection_of_clinically_relevant_pain_relief_in_cats_with_degenerative_joint_disease_associated_pain_ L2 - https://doi.org/10.1111/jvim.12312 DB - PRIME DP - Unbound Medicine ER -