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Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes.
J Diabetes Complications. 2014 May-Jun; 28(3):291-7.JD

Abstract

AIM

To assess the prevalence and risk factors for diabetic retinopathy (DR) in people with young onset type 1 (T1DM-Y) and type 2 diabetes (T2DM-Y).

METHODS

T1DM-Y(n=150) and T2DM-Y(n=150) participants, age between 10 and 25 years at diagnosis, had a complete clinical evaluation, biochemical assessment, and four field digital retinal colour photography. The Early Treatment Diabetic Retinopathy Study grading system was used to grade DR. Proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) were considered as sight threatening DR.

RESULTS

The prevalence of any DR was 53.3% [95% CI 45.3-61.3] in T1DM-Y (duration of diabetes: 12.4±7.4 years) and 52.7% [44.7-60.7] in T2DM-Y (11.8±8.3 years). The age and gender adjusted prevalence of DR, DME and PDR was 62.5%, 10% and 7.3% in T1DM-Y, whereas it was 65.8%,12.7% and 9.3% in T2DM-Y respectively. In multivariable logistic regression, diabetes duration [Odds ratio (OR) 1.99 per 5 years; CI 1.42-2.79], waist circumference [1.28 per 5 cm;1.05-1.56] and microalbuminuria [2.39 per 50 μg;1.07-5.31] were associated with DR in T1DM-Y, and diabetes duration [2.21 per 5 years; 1.61-3.02], diastolic blood pressure [1.54 per 5 mmHg;1.18-2.02], Glycated hemoglobin [1.37 per %;1.07-1.75] and lower stimulated C-peptide [1.54 per 0.5 pmol/ml;1.15-2.05;] were associated with DR in T2DM-Y.

CONCLUSION

Over half of the people with young-onset diabetes, regardless of type, have retinopathy within 10-12 years of diabetes duration, emphasizing the need for regular eye screening and aggressive control of glucose and blood pressure to prevent DR.

Authors+Show Affiliations

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India.Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India.Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India.Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA.Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India.Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India.Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA.Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India. Electronic address: drmohans@diabetes.ind.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24512748

Citation

Rajalakshmi, Ramachandran, et al. "Prevalence and Risk Factors for Diabetic Retinopathy in Asian Indians With Young Onset Type 1 and Type 2 Diabetes." Journal of Diabetes and Its Complications, vol. 28, no. 3, 2014, pp. 291-7.
Rajalakshmi R, Amutha A, Ranjani H, et al. Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes. J Diabetes Complications. 2014;28(3):291-7.
Rajalakshmi, R., Amutha, A., Ranjani, H., Ali, M. K., Unnikrishnan, R., Anjana, R. M., Narayan, K. M., & Mohan, V. (2014). Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes. Journal of Diabetes and Its Complications, 28(3), 291-7. https://doi.org/10.1016/j.jdiacomp.2013.12.008
Rajalakshmi R, et al. Prevalence and Risk Factors for Diabetic Retinopathy in Asian Indians With Young Onset Type 1 and Type 2 Diabetes. J Diabetes Complications. 2014 May-Jun;28(3):291-7. PubMed PMID: 24512748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes. AU - Rajalakshmi,Ramachandran, AU - Amutha,Anandakumar, AU - Ranjani,Harish, AU - Ali,Mohammed K, AU - Unnikrishnan,Ranjit, AU - Anjana,Ranjit Mohan, AU - Narayan,K M Venkat, AU - Mohan,Viswanathan, Y1 - 2014/01/06/ PY - 2013/09/26/received PY - 2013/11/29/revised PY - 2013/12/23/accepted PY - 2014/2/12/entrez PY - 2014/2/12/pubmed PY - 2015/2/11/medline KW - Asian Indians KW - Diabetic retinopathy KW - Prevalence KW - Risk factors KW - T1DM-Y KW - T2DM-Y SP - 291 EP - 7 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 28 IS - 3 N2 - AIM: To assess the prevalence and risk factors for diabetic retinopathy (DR) in people with young onset type 1 (T1DM-Y) and type 2 diabetes (T2DM-Y). METHODS: T1DM-Y(n=150) and T2DM-Y(n=150) participants, age between 10 and 25 years at diagnosis, had a complete clinical evaluation, biochemical assessment, and four field digital retinal colour photography. The Early Treatment Diabetic Retinopathy Study grading system was used to grade DR. Proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) were considered as sight threatening DR. RESULTS: The prevalence of any DR was 53.3% [95% CI 45.3-61.3] in T1DM-Y (duration of diabetes: 12.4±7.4 years) and 52.7% [44.7-60.7] in T2DM-Y (11.8±8.3 years). The age and gender adjusted prevalence of DR, DME and PDR was 62.5%, 10% and 7.3% in T1DM-Y, whereas it was 65.8%,12.7% and 9.3% in T2DM-Y respectively. In multivariable logistic regression, diabetes duration [Odds ratio (OR) 1.99 per 5 years; CI 1.42-2.79], waist circumference [1.28 per 5 cm;1.05-1.56] and microalbuminuria [2.39 per 50 μg;1.07-5.31] were associated with DR in T1DM-Y, and diabetes duration [2.21 per 5 years; 1.61-3.02], diastolic blood pressure [1.54 per 5 mmHg;1.18-2.02], Glycated hemoglobin [1.37 per %;1.07-1.75] and lower stimulated C-peptide [1.54 per 0.5 pmol/ml;1.15-2.05;] were associated with DR in T2DM-Y. CONCLUSION: Over half of the people with young-onset diabetes, regardless of type, have retinopathy within 10-12 years of diabetes duration, emphasizing the need for regular eye screening and aggressive control of glucose and blood pressure to prevent DR. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/24512748/Prevalence_and_risk_factors_for_diabetic_retinopathy_in_Asian_Indians_with_young_onset_type_1_and_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(13)00334-6 DB - PRIME DP - Unbound Medicine ER -