TY - JOUR T1 - Role of cytological and ultrasonographic features in predicting the risk of malignancy in thyroid nodules with indeterminate cytology. AU - Saiegh,L, AU - Shechner,C, AU - Dickstein,G, AU - Sheikh-Ahmad,M, AU - Reut,M, AU - Odeh,M, AU - Toubi,A, AU - Bejar,J, PY - 2014/2/12/entrez PY - 2014/2/12/pubmed PY - 2014/5/14/medline SP - 43 EP - 52 JF - Minerva endocrinologica JO - Minerva Endocrinol VL - 39 IS - 1 N2 - AIM: The aim of this paper was to examine the diagnostic value of several cytological and ultrasonographic features in predicting malignancy in thyroid follicular neoplasms. METHODS: The sample of the study consisted of 145 patients, who have had the diagnosis of follicular neoplasm on US guided fine-needle aspiration (FNA), and had undergone thyroidectomy. The cytological slides and the ultrasonographic images were reviewed, and several ultrasonographic and cytological features were evaluated and correlated with final histology. RESULTS: Histological diagnosis of malignancy was obtained in 14.5% of the patients, papillary carcinoma being the most frequent (66% of malignancies). The cytological and ultrasonographic features that have been associated with malignancy were: micro-fragments (P<0.00001), overlapping (P<0.005), hypercellularity (P<0.009), micronucleoli (P<0.013), atypical features (P<0.027), nodule size larger than 2 cm (P<0.029) and micro-calcifications (P<0.0002). Using the features that were statistically independent ones, which included two cytological features: micro-fragments and micronuclei, and one ultrasonographic feature: micro-calcifications, a statistical model for predicting malignancy was constructed. According to this model, it was found that the risk for malignancy is 2.65% in the absence of the three parameters, and amounts to 93.93% in the presence of all three of them. CONCLUSION: In a thyroid follicular neoplasm, the cytological and ultrasonographic features that were associated with malignancy were: micro-fragments, overlapping, hypercellularity, micronucleoli, atypical features, nodule size larger than 2 cm and micro-calcifications. In an attempt to predict malignancy, we proposed a simple statistical model using only three features derived from cytological and ultrasonographic tests. SN - 0391-1977 UR - https://www.unboundmedicine.com/medline/citation/24513603/Role_of_cytological_and_ultrasonographic_features_in_predicting_the_risk_of_malignancy_in_thyroid_nodules_with_indeterminate_cytology_ L2 - http://www.minervamedica.it/index2.t?show=R07Y2014N01A0043 DB - PRIME DP - Unbound Medicine ER -