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Duration of protection after first dose of acellular pertussis vaccine in infants.
Pediatrics. 2014 Mar; 133(3):e513-9.Ped

Abstract

OBJECTIVE

Data on the effectiveness of the diphtheria-tetanus-acellular pertussis (DTaP) vaccine in the first 4 years of life are sparse. We evaluated the vaccine effectiveness (VE) of 1 and 2 doses of DTaP before 6 months of age and of 3 doses from 6 months of age in Australia, where, since 2003, a fourth dose is not given until 4 years.

METHODS

We matched reported pertussis cases aged 2 to 47 months between January 2005 and December 2009 to controls from a population-based immunization register by date of birth and region of residence. VE by number of doses and age group was calculated as (1 - odds ratio) × 100%.

RESULTS

VE against hospitalization increased from 55.3% (95% confidence interval [CI], 42.7%-65.1%) for 1 dose before 4 months of age to 83.0% (95% CI, 70.2%-90.3%) for 2 doses before 6 months. The VE of 3 doses of DTaP against all reported pertussis was 83.5% (95% CI, 79.1%-87.8%) between 6 and 11 months, declining to 70.7% (95% CI, 64.5%-75.8%) between 2 and 3 years of age and 59.2% (95% CI, 51.0%-66.0%) between 3 and 4 years of age.

CONCLUSIONS

DTaP provided good protection against pertussis in the first year of life from the first dose. Without a booster dose, the effectiveness of 3 doses waned more rapidly from 2 to 4 years of age than previously documented for children >6 years of age who had received 5 doses.

Authors+Show Affiliations

National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, and.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24515514

Citation

Quinn, Helen E., et al. "Duration of Protection After First Dose of Acellular Pertussis Vaccine in Infants." Pediatrics, vol. 133, no. 3, 2014, pp. e513-9.
Quinn HE, Snelling TL, Macartney KK, et al. Duration of protection after first dose of acellular pertussis vaccine in infants. Pediatrics. 2014;133(3):e513-9.
Quinn, H. E., Snelling, T. L., Macartney, K. K., & McIntyre, P. B. (2014). Duration of protection after first dose of acellular pertussis vaccine in infants. Pediatrics, 133(3), e513-9. https://doi.org/10.1542/peds.2013-3181
Quinn HE, et al. Duration of Protection After First Dose of Acellular Pertussis Vaccine in Infants. Pediatrics. 2014;133(3):e513-9. PubMed PMID: 24515514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of protection after first dose of acellular pertussis vaccine in infants. AU - Quinn,Helen E, AU - Snelling,Thomas L, AU - Macartney,Kristine K, AU - McIntyre,Peter B, Y1 - 2014/02/10/ PY - 2014/2/12/entrez PY - 2014/2/12/pubmed PY - 2014/4/30/medline KW - effectiveness KW - immunization KW - pertussis KW - vaccine KW - waning SP - e513 EP - 9 JF - Pediatrics JO - Pediatrics VL - 133 IS - 3 N2 - OBJECTIVE: Data on the effectiveness of the diphtheria-tetanus-acellular pertussis (DTaP) vaccine in the first 4 years of life are sparse. We evaluated the vaccine effectiveness (VE) of 1 and 2 doses of DTaP before 6 months of age and of 3 doses from 6 months of age in Australia, where, since 2003, a fourth dose is not given until 4 years. METHODS: We matched reported pertussis cases aged 2 to 47 months between January 2005 and December 2009 to controls from a population-based immunization register by date of birth and region of residence. VE by number of doses and age group was calculated as (1 - odds ratio) × 100%. RESULTS: VE against hospitalization increased from 55.3% (95% confidence interval [CI], 42.7%-65.1%) for 1 dose before 4 months of age to 83.0% (95% CI, 70.2%-90.3%) for 2 doses before 6 months. The VE of 3 doses of DTaP against all reported pertussis was 83.5% (95% CI, 79.1%-87.8%) between 6 and 11 months, declining to 70.7% (95% CI, 64.5%-75.8%) between 2 and 3 years of age and 59.2% (95% CI, 51.0%-66.0%) between 3 and 4 years of age. CONCLUSIONS: DTaP provided good protection against pertussis in the first year of life from the first dose. Without a booster dose, the effectiveness of 3 doses waned more rapidly from 2 to 4 years of age than previously documented for children >6 years of age who had received 5 doses. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/24515514/Duration_of_protection_after_first_dose_of_acellular_pertussis_vaccine_in_infants_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=24515514 DB - PRIME DP - Unbound Medicine ER -