Tags

Type your tag names separated by a space and hit enter

Ondansetron preloading with crystalloid infusion reduces maternal hypotension during cesarean delivery.
Am J Perinatol. 2014 Nov; 31(10):913-22.AJ

Abstract

OBJECTIVE

The aim of the article was to investigate the effect of ondansetron preloading with crystalloid infusion after spinal anesthesia during cesarean delivery.

STUDY DESIGN

A total of 66 parturient women scheduled for elective caesarean sections were randomly assigned to two groups. Five minutes before spinal anesthesia, Group O patients were injected with 4 mg of ondansetron, while Group S patients were injected with 5 mL physiological saline. Maternal blood pressure and heart rate were measured at 2 minute intervals for 30 minutes. After delivery, umbilical cord blood samples were analyzed.

RESULTS

Maternal hypotension and nausea were significantly lower in ondansetron-treated patients versus placebo (p = 0.011 vs. 0.004). Umbilical venous pH was significantly higher in ondansetron-treated patients (p = 0.006), while partial pressure of carbon dioxide (Pco 2) was significantly lower (p = 0.002). Decreases in maternal systolic and mean arterial blood pressures were significantly lower in ondansetron-treated patients (p = 0.008 vs. 0.025), with less requirement for phenylephrine administration compared with controls (p = 0.029).

CONCLUSION

Ondansetron preloading combined with crystalloid infusion significantly reduced hypotension and nausea, while improving acid-base status, as well as reducing vasoconstrictor use.

Authors+Show Affiliations

Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.School of Public Health, Xuzhou Medical College, Xuzhou, China.Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24515619

Citation

Wang, Qun, et al. "Ondansetron Preloading With Crystalloid Infusion Reduces Maternal Hypotension During Cesarean Delivery." American Journal of Perinatology, vol. 31, no. 10, 2014, pp. 913-22.
Wang Q, Zhuo L, Shen MK, et al. Ondansetron preloading with crystalloid infusion reduces maternal hypotension during cesarean delivery. Am J Perinatol. 2014;31(10):913-22.
Wang, Q., Zhuo, L., Shen, M. K., Yu, Y. Y., Yu, J. J., & Wang, M. (2014). Ondansetron preloading with crystalloid infusion reduces maternal hypotension during cesarean delivery. American Journal of Perinatology, 31(10), 913-22. https://doi.org/10.1055/s-0033-1364189
Wang Q, et al. Ondansetron Preloading With Crystalloid Infusion Reduces Maternal Hypotension During Cesarean Delivery. Am J Perinatol. 2014;31(10):913-22. PubMed PMID: 24515619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron preloading with crystalloid infusion reduces maternal hypotension during cesarean delivery. AU - Wang,Qun, AU - Zhuo,Lang, AU - Shen,Ming-Kun, AU - Yu,Yan-Yun, AU - Yu,Jun-Jing, AU - Wang,Meng, Y1 - 2014/02/10/ PY - 2014/2/12/entrez PY - 2014/2/12/pubmed PY - 2015/5/30/medline SP - 913 EP - 22 JF - American journal of perinatology JO - Am J Perinatol VL - 31 IS - 10 N2 - OBJECTIVE: The aim of the article was to investigate the effect of ondansetron preloading with crystalloid infusion after spinal anesthesia during cesarean delivery. STUDY DESIGN: A total of 66 parturient women scheduled for elective caesarean sections were randomly assigned to two groups. Five minutes before spinal anesthesia, Group O patients were injected with 4 mg of ondansetron, while Group S patients were injected with 5 mL physiological saline. Maternal blood pressure and heart rate were measured at 2 minute intervals for 30 minutes. After delivery, umbilical cord blood samples were analyzed. RESULTS: Maternal hypotension and nausea were significantly lower in ondansetron-treated patients versus placebo (p = 0.011 vs. 0.004). Umbilical venous pH was significantly higher in ondansetron-treated patients (p = 0.006), while partial pressure of carbon dioxide (Pco 2) was significantly lower (p = 0.002). Decreases in maternal systolic and mean arterial blood pressures were significantly lower in ondansetron-treated patients (p = 0.008 vs. 0.025), with less requirement for phenylephrine administration compared with controls (p = 0.029). CONCLUSION: Ondansetron preloading combined with crystalloid infusion significantly reduced hypotension and nausea, while improving acid-base status, as well as reducing vasoconstrictor use. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/24515619/Ondansetron_preloading_with_crystalloid_infusion_reduces_maternal_hypotension_during_cesarean_delivery_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1364189 DB - PRIME DP - Unbound Medicine ER -