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Cancer drugs inhibit morphogenesis in the human fungal pathogen, Candida albicans.

Abstract

Candida infections are very common in cancer patients and it is a common practice to prescribe antifungal antibiotics along with anticancer drugs. Yeast to hyphal form switching is considered to be important in invasive candidiasis. Targeting morphogenetic switching may be useful against invasive candidiasis. In this study, we report the antimorphogenetic properties of thirty cancer drugs.

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  • Authors

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    Source

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24516452

    Citation

    TY - JOUR T1 - Cancer drugs inhibit morphogenesis in the human fungal pathogen, Candida albicans. AU - Routh,Madhushree M, AU - Chauhan,Nitin M, AU - Karuppayil,S Mohan, Y1 - 2014/01/15/ PY - 2013///ecollection PY - 2012/1/21/received PY - 2012/9/10/accepted PY - 2014/1/15/epublish PY - 2014/2/12/entrez PY - 2014/2/12/pubmed PY - 2014/2/12/medline KW - Candida albicans KW - antifungal antibiotics KW - cancer drugs KW - morphogenetic switching SP - 855 EP - 9 JF - Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] JO - Braz. J. Microbiol. VL - 44 IS - 3 N2 - Candida infections are very common in cancer patients and it is a common practice to prescribe antifungal antibiotics along with anticancer drugs. Yeast to hyphal form switching is considered to be important in invasive candidiasis. Targeting morphogenetic switching may be useful against invasive candidiasis. In this study, we report the antimorphogenetic properties of thirty cancer drugs. SN - 1678-4405 UR - https://www.unboundmedicine.com/medline/citation/24516452/Cancer_drugs_inhibit_morphogenesis_in_the_human_fungal_pathogen_Candida_albicans_ L2 - http://europepmc.org/abstract/MED/24516452 ER -