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Age-dependent changes in stratum corneum barrier function.
Skin Res Technol. 2014 Nov; 20(4):409-15.SR

Abstract

BACKGROUND/PURPOSE

The Stratum Corneum (SC) barrier function mainly depends on the SC structure at the tissue level, its composition, and the organization of intercellular lipidic cement at the molecular level. The goal of this study was to assess the age-dependent changes of the SC barrier function and the associated physiological parameters.

METHODS

This study was conducted on 40 French women divided into four groups of age. Measurements were done on three sites: cheek, protected, and exposed arm sites. SC composition (water, lipid/protein ratio, cholesterol, and ceramides) was measured using Raman confocal microspectroscopy, skin surface hydration using skin conductance, and barrier function through transepidermal water loss (TEWL) measurements.

RESULTS

Transepidermal water loss decreases slightly with age, which is partially explained by the age-dependent increase in SC thickness. This decrease is faster for the face compared to both arm sites. The lipid to protein ratio and lipid compactness decrease significantly with age only for the arm sites. Water concentration profiles only decrease very close to the skin surface. At all ages tested, the SC on the cheek showed significantly higher TEWL, water and lipid content and less thickness compared to the arm sites. Comparison of the exposed to unexposed arm site showed difference only for the lipid compactness at the older group studied.

CONCLUSION

Skin aging, body site and environmental exposure can affect the SC barrier function, its structure, and its lipid content. The thickening of the SC with age compensates for the decrease of the quantity and ordering of the lipidic cement.

Authors+Show Affiliations

Faculté de pharmacie, EA 4041, Université Paris Sud 11, Châtenay-Malabry Cedex, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24517174

Citation

Boireau-Adamezyk, E, et al. "Age-dependent Changes in Stratum Corneum Barrier Function." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), vol. 20, no. 4, 2014, pp. 409-15.
Boireau-Adamezyk E, Baillet-Guffroy A, Stamatas GN. Age-dependent changes in stratum corneum barrier function. Skin Res Technol. 2014;20(4):409-15.
Boireau-Adamezyk, E., Baillet-Guffroy, A., & Stamatas, G. N. (2014). Age-dependent changes in stratum corneum barrier function. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 20(4), 409-15. https://doi.org/10.1111/srt.12132
Boireau-Adamezyk E, Baillet-Guffroy A, Stamatas GN. Age-dependent Changes in Stratum Corneum Barrier Function. Skin Res Technol. 2014;20(4):409-15. PubMed PMID: 24517174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent changes in stratum corneum barrier function. AU - Boireau-Adamezyk,E, AU - Baillet-Guffroy,A, AU - Stamatas,G N, Y1 - 2014/02/12/ PY - 2014/01/04/accepted PY - 2014/2/13/entrez PY - 2014/2/13/pubmed PY - 2015/6/16/medline KW - barrier function KW - raman spectroscopy KW - skin aging KW - skin lipids SP - 409 EP - 15 JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol VL - 20 IS - 4 N2 - BACKGROUND/PURPOSE: The Stratum Corneum (SC) barrier function mainly depends on the SC structure at the tissue level, its composition, and the organization of intercellular lipidic cement at the molecular level. The goal of this study was to assess the age-dependent changes of the SC barrier function and the associated physiological parameters. METHODS: This study was conducted on 40 French women divided into four groups of age. Measurements were done on three sites: cheek, protected, and exposed arm sites. SC composition (water, lipid/protein ratio, cholesterol, and ceramides) was measured using Raman confocal microspectroscopy, skin surface hydration using skin conductance, and barrier function through transepidermal water loss (TEWL) measurements. RESULTS: Transepidermal water loss decreases slightly with age, which is partially explained by the age-dependent increase in SC thickness. This decrease is faster for the face compared to both arm sites. The lipid to protein ratio and lipid compactness decrease significantly with age only for the arm sites. Water concentration profiles only decrease very close to the skin surface. At all ages tested, the SC on the cheek showed significantly higher TEWL, water and lipid content and less thickness compared to the arm sites. Comparison of the exposed to unexposed arm site showed difference only for the lipid compactness at the older group studied. CONCLUSION: Skin aging, body site and environmental exposure can affect the SC barrier function, its structure, and its lipid content. The thickening of the SC with age compensates for the decrease of the quantity and ordering of the lipidic cement. SN - 1600-0846 UR - https://www.unboundmedicine.com/medline/citation/24517174/Age_dependent_changes_in_stratum_corneum_barrier_function_ L2 - https://doi.org/10.1111/srt.12132 DB - PRIME DP - Unbound Medicine ER -