Tags

Type your tag names separated by a space and hit enter

Adrenalin, noradrenalin and heart rate responses to psychosocial stress in young adults born preterm at very low birthweight.
Clin Endocrinol (Oxf). 2014 Aug; 81(2):231-7.CE

Abstract

OBJECTIVE

Adults born preterm at very low birthweight (VLBW; ≤ 1500 g) have high levels of cardiovascular risk factors and altered responses to psychosocial stress including higher blood pressure and lower cortisol. Our aim was to investigate adrenalin (A), noradrenalin (NA) and heart rate (HR) responses to psychosocial stress in adults born preterm at VLBW.

DESIGN AND PARTICIPANTS

We studied 50 young adults, aged 19-27 years, born at VLBW and 39 term-born controls, group-matched for age, sex and birth hospital. They underwent a standardized psychosocial stress test, the Trier Social Stress Test (TSST).

MEASUREMENTS

During TSST, A, NA (baseline and 0, 10 and 90 min after stress) and HR were measured. Data were analysed with mixed-effects and linear regression models, adjusted for age, sex, body mass index, hormonal contraception, time of day and highest parental educational attainment.

RESULTS

Baseline concentrations, peak after stress, increments and area under the curve for A and NA were similar in VLBW and control groups. In women, NA concentrations were 27.7% lower (95% CI; 3.1-52.2) in VLBW compared with control women; in men, there was no significant difference. A concentrations were similar for VLBW and control groups in both sexes. Mean HR at baseline, task and HR reactivity was also similar in VLBW and control groups.

CONCLUSIONS

Very low-birthweight women seem to have a lower NA response to stress compared with term-born peers. If replicated, this could be a protective characteristic for cardiovascular diseases.

Authors+Show Affiliations

Department of Chronic Disease and Diabetes Prevention, National Institute for Health and Welfare, Helsinki, Finland; Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24521432

Citation

Kaseva, Nina, et al. "Adrenalin, Noradrenalin and Heart Rate Responses to Psychosocial Stress in Young Adults Born Preterm at Very Low Birthweight." Clinical Endocrinology, vol. 81, no. 2, 2014, pp. 231-7.
Kaseva N, Pyhälä R, Wehkalampi K, et al. Adrenalin, noradrenalin and heart rate responses to psychosocial stress in young adults born preterm at very low birthweight. Clin Endocrinol (Oxf). 2014;81(2):231-7.
Kaseva, N., Pyhälä, R., Wehkalampi, K., Feldt, K., Pesonen, A. K., Heinonen, K., Hovi, P., Järvenpää, A. L., Eriksson, J. G., Andersson, S., Räikkönen, K., & Kajantie, E. (2014). Adrenalin, noradrenalin and heart rate responses to psychosocial stress in young adults born preterm at very low birthweight. Clinical Endocrinology, 81(2), 231-7. https://doi.org/10.1111/cen.12425
Kaseva N, et al. Adrenalin, Noradrenalin and Heart Rate Responses to Psychosocial Stress in Young Adults Born Preterm at Very Low Birthweight. Clin Endocrinol (Oxf). 2014;81(2):231-7. PubMed PMID: 24521432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adrenalin, noradrenalin and heart rate responses to psychosocial stress in young adults born preterm at very low birthweight. AU - Kaseva,Nina, AU - Pyhälä,Riikka, AU - Wehkalampi,Karoliina, AU - Feldt,Kimmo, AU - Pesonen,Anu-Katriina, AU - Heinonen,Kati, AU - Hovi,Petteri, AU - Järvenpää,Anna-Liisa, AU - Eriksson,Johan G, AU - Andersson,Sture, AU - Räikkönen,Katri, AU - Kajantie,Eero, Y1 - 2014/03/07/ PY - 2013/12/10/received PY - 2014/01/06/revised PY - 2014/02/02/revised PY - 2014/02/06/accepted PY - 2014/2/14/entrez PY - 2014/2/14/pubmed PY - 2015/3/31/medline SP - 231 EP - 7 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 81 IS - 2 N2 - OBJECTIVE: Adults born preterm at very low birthweight (VLBW; ≤ 1500 g) have high levels of cardiovascular risk factors and altered responses to psychosocial stress including higher blood pressure and lower cortisol. Our aim was to investigate adrenalin (A), noradrenalin (NA) and heart rate (HR) responses to psychosocial stress in adults born preterm at VLBW. DESIGN AND PARTICIPANTS: We studied 50 young adults, aged 19-27 years, born at VLBW and 39 term-born controls, group-matched for age, sex and birth hospital. They underwent a standardized psychosocial stress test, the Trier Social Stress Test (TSST). MEASUREMENTS: During TSST, A, NA (baseline and 0, 10 and 90 min after stress) and HR were measured. Data were analysed with mixed-effects and linear regression models, adjusted for age, sex, body mass index, hormonal contraception, time of day and highest parental educational attainment. RESULTS: Baseline concentrations, peak after stress, increments and area under the curve for A and NA were similar in VLBW and control groups. In women, NA concentrations were 27.7% lower (95% CI; 3.1-52.2) in VLBW compared with control women; in men, there was no significant difference. A concentrations were similar for VLBW and control groups in both sexes. Mean HR at baseline, task and HR reactivity was also similar in VLBW and control groups. CONCLUSIONS: Very low-birthweight women seem to have a lower NA response to stress compared with term-born peers. If replicated, this could be a protective characteristic for cardiovascular diseases. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/24521432/Adrenalin_noradrenalin_and_heart_rate_responses_to_psychosocial_stress_in_young_adults_born_preterm_at_very_low_birthweight_ L2 - https://doi.org/10.1111/cen.12425 DB - PRIME DP - Unbound Medicine ER -