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Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes.
Int J Radiat Oncol Biol Phys 2014; 88(3):650-4IJ

Abstract

PURPOSE

To evaluate the natural history, behavior of progression, prognostic factors, and treatment-related adverse effects of primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma (POAML).

METHODS AND MATERIALS

Eighty-six patients with histologically proven stage I POAML treated with radiation therapy at National Cancer Center Hospital, Tokyo between 1990 and 2010 were retrospectively reviewed. The median age was 56 years (range, 18-85 years). The median dose administered was 30 Gy (range, 30-46 Gy). Seventy-seven patients (90%) were treated by radiation therapy alone.

RESULTS

The median follow-up duration was 9 years (range, 0.9-22 years). The 5- and 10-year overall survival (OS) rates were 97.6% and 93.5%, respectively, and no patients died of lymphoma. Patients with tumor sizes ≥4 cm showed a greater risk of contralateral relapse (P=.012). Six patients with contralateral relapse were seen and treated by radiation therapy alone, and all the lesions were controlled well, with follow-up times of 3 to 12 years. There was 1 case of local relapse after radiation therapy alone, and 3 cases of relapse occurred in a distant site. Cataracts developed in 36 of the 65 eyes treated without lens shielding and in 12 of the 39 patients with lens shielding (P=.037).

CONCLUSIONS

The majority of patients with POAML showed behavior consistent with that of localized, indolent diseases. Thirty gray of local irradiation seems to be quite effective. The initial bilateral involvement and contralateral orbital relapses can be also controlled with radiation therapy alone. Lens shielding reduces the risk of cataract.

Authors+Show Affiliations

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan. Electronic address: keharada@ncc.go.jp.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Hematologic Oncology, National Cancer Center Hospital, Tokyo, Japan.Department of Radiology, Chiba University School of Medicine, Chiba, Japan.Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24521680

Citation

Harada, Ken, et al. "Localized Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy: a Long-term Outcome in 86 Patients With 104 Treated Eyes." International Journal of Radiation Oncology, Biology, Physics, vol. 88, no. 3, 2014, pp. 650-4.
Harada K, Murakami N, Kitaguchi M, et al. Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes. Int J Radiat Oncol Biol Phys. 2014;88(3):650-4.
Harada, K., Murakami, N., Kitaguchi, M., Sekii, S., Takahashi, K., Yoshio, K., ... Itami, J. (2014). Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes. International Journal of Radiation Oncology, Biology, Physics, 88(3), pp. 650-4. doi:10.1016/j.ijrobp.2013.11.235.
Harada K, et al. Localized Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy: a Long-term Outcome in 86 Patients With 104 Treated Eyes. Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):650-4. PubMed PMID: 24521680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes. AU - Harada,Ken, AU - Murakami,Naoya, AU - Kitaguchi,Mayuka, AU - Sekii,Shuhei, AU - Takahashi,Kana, AU - Yoshio,Kotaro, AU - Inaba,Koji, AU - Morota,Madoka, AU - Ito,Yoshinori, AU - Sumi,Minako, AU - Suzuki,Shigenobu, AU - Tobinai,Kensei, AU - Uno,Takashi, AU - Itami,Jun, PY - 2013/09/25/received PY - 2013/11/10/revised PY - 2013/11/12/accepted PY - 2014/2/14/entrez PY - 2014/2/14/pubmed PY - 2014/4/1/medline SP - 650 EP - 4 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 88 IS - 3 N2 - PURPOSE: To evaluate the natural history, behavior of progression, prognostic factors, and treatment-related adverse effects of primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma (POAML). METHODS AND MATERIALS: Eighty-six patients with histologically proven stage I POAML treated with radiation therapy at National Cancer Center Hospital, Tokyo between 1990 and 2010 were retrospectively reviewed. The median age was 56 years (range, 18-85 years). The median dose administered was 30 Gy (range, 30-46 Gy). Seventy-seven patients (90%) were treated by radiation therapy alone. RESULTS: The median follow-up duration was 9 years (range, 0.9-22 years). The 5- and 10-year overall survival (OS) rates were 97.6% and 93.5%, respectively, and no patients died of lymphoma. Patients with tumor sizes ≥4 cm showed a greater risk of contralateral relapse (P=.012). Six patients with contralateral relapse were seen and treated by radiation therapy alone, and all the lesions were controlled well, with follow-up times of 3 to 12 years. There was 1 case of local relapse after radiation therapy alone, and 3 cases of relapse occurred in a distant site. Cataracts developed in 36 of the 65 eyes treated without lens shielding and in 12 of the 39 patients with lens shielding (P=.037). CONCLUSIONS: The majority of patients with POAML showed behavior consistent with that of localized, indolent diseases. Thirty gray of local irradiation seems to be quite effective. The initial bilateral involvement and contralateral orbital relapses can be also controlled with radiation therapy alone. Lens shielding reduces the risk of cataract. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/24521680/Localized_ocular_adnexal_mucosa_associated_lymphoid_tissue_lymphoma_treated_with_radiation_therapy:_a_long_term_outcome_in_86_patients_with_104_treated_eyes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(13)03596-7 DB - PRIME DP - Unbound Medicine ER -