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Lithium prevents acrolein-induced neurotoxicity in HT22 mouse hippocampal cells.
Neurochem Res. 2014 Apr; 39(4):677-84.NR

Abstract

Acrolein is a highly electrophilic alpha, beta-unsaturated aldehyde to which humans are exposed in many situations and has been implicated in neurodegenerative diseases, such as Alzheimer's disease. Lithium is demonstrated to have neuroprotective and neurotrophic effects in brain ischemia, trauma, neurodegenerative disorders, and psychiatric disorders. Previously we have found that acrolein induced neuronal death in HT22 mouse hippocampal cells. In this study, the effects of lithium on the acrolein-induced neurotoxicity in HT22 cells as well as its mechanism(s) were investigated. We found that lithium protected HT22 cells against acrolein-induced damage by the attenuation of reactive oxygen species and the enhancement of the glutathione level. Lithium also attenuated the mitochondrial dysfunction caused by acrolein. Furthermore, lithium significantly increased the level of phospho-glycogen synthase kinase-3 beta (GSK-3β), the non-activated GSK-3β. Taken together, our findings suggest that lithium is a protective agent for acrolein-related neurotoxicity.

Authors+Show Affiliations

Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Zhongshan 2 Rd. 58, Guangzhou, 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24522749

Citation

Huang, Yingjuan, et al. "Lithium Prevents Acrolein-induced Neurotoxicity in HT22 Mouse Hippocampal Cells." Neurochemical Research, vol. 39, no. 4, 2014, pp. 677-84.
Huang Y, Qin J, Chen M, et al. Lithium prevents acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurochem Res. 2014;39(4):677-84.
Huang, Y., Qin, J., Chen, M., Chao, X., Chen, Z., Ramassamy, C., Pi, R., & Jin, M. (2014). Lithium prevents acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurochemical Research, 39(4), 677-84. https://doi.org/10.1007/s11064-014-1252-z
Huang Y, et al. Lithium Prevents Acrolein-induced Neurotoxicity in HT22 Mouse Hippocampal Cells. Neurochem Res. 2014;39(4):677-84. PubMed PMID: 24522749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lithium prevents acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. AU - Huang,Yingjuan, AU - Qin,Jian, AU - Chen,Meihui, AU - Chao,Xiaojuan, AU - Chen,Ziwei, AU - Ramassamy,Charles, AU - Pi,Rongbiao, AU - Jin,Minghua, Y1 - 2014/02/13/ PY - 2013/11/28/received PY - 2014/01/29/accepted PY - 2014/01/18/revised PY - 2014/2/14/entrez PY - 2014/2/14/pubmed PY - 2014/12/15/medline SP - 677 EP - 84 JF - Neurochemical research JO - Neurochem Res VL - 39 IS - 4 N2 - Acrolein is a highly electrophilic alpha, beta-unsaturated aldehyde to which humans are exposed in many situations and has been implicated in neurodegenerative diseases, such as Alzheimer's disease. Lithium is demonstrated to have neuroprotective and neurotrophic effects in brain ischemia, trauma, neurodegenerative disorders, and psychiatric disorders. Previously we have found that acrolein induced neuronal death in HT22 mouse hippocampal cells. In this study, the effects of lithium on the acrolein-induced neurotoxicity in HT22 cells as well as its mechanism(s) were investigated. We found that lithium protected HT22 cells against acrolein-induced damage by the attenuation of reactive oxygen species and the enhancement of the glutathione level. Lithium also attenuated the mitochondrial dysfunction caused by acrolein. Furthermore, lithium significantly increased the level of phospho-glycogen synthase kinase-3 beta (GSK-3β), the non-activated GSK-3β. Taken together, our findings suggest that lithium is a protective agent for acrolein-related neurotoxicity. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/24522749/Lithium_prevents_acrolein_induced_neurotoxicity_in_HT22_mouse_hippocampal_cells_ L2 - https://doi.org/10.1007/s11064-014-1252-z DB - PRIME DP - Unbound Medicine ER -