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Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 2nd communication: inhibitory effects on histamine release from rat mast cells and lung fragments.
Arzneimittelforschung. 1988 Jan; 38(1):75-9.A

Abstract

The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on its ability to inhibit histamine release from both peritoneal mast cells and lung fragments of rats were investigated. WP-833 inhibited in a dose-dependent fashion immunoglobulin E (IgE)-mediated histamine release from mast cells. Such potent inhibition was observed in glucose-free as well as complete Tyrode's solution but neither in Ca2+-free nor D2O-supplemented Tyrode's solution. In addition, WP-833 significantly increased intracellular cyclic adenosine monophosphate (AMP) levels in purified mast cells. On the other hand, WP-833 inhibited compound 48/80-but not calcium ionophore A23187-induced histamine release from normal mast cells. Also both IgE- and IgG-mediated histamine release from lung fragments were inhibited by WP-833. WP-833 showed non-competitive inhibition of cyclic AMP-dependent phosphodiesterase derived from lung preparations.

Authors+Show Affiliations

Clinical Research Center of Allergy, National Sagamihara Hospital, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2452639

Citation

Yanagihara, Y, et al. "Immunopharmacological Actions of the New Antiallergic Drug Butyl 3'-(1H-tetrazol-5-yl)oxanilate. 2nd Communication: Inhibitory Effects On Histamine Release From Rat Mast Cells and Lung Fragments." Arzneimittel-Forschung, vol. 38, no. 1, 1988, pp. 75-9.
Yanagihara Y, Abe T, Kuroda T, et al. Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 2nd communication: inhibitory effects on histamine release from rat mast cells and lung fragments. Arzneimittelforschung. 1988;38(1):75-9.
Yanagihara, Y., Abe, T., Kuroda, T., & Shida, T. (1988). Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 2nd communication: inhibitory effects on histamine release from rat mast cells and lung fragments. Arzneimittel-Forschung, 38(1), 75-9.
Yanagihara Y, et al. Immunopharmacological Actions of the New Antiallergic Drug Butyl 3'-(1H-tetrazol-5-yl)oxanilate. 2nd Communication: Inhibitory Effects On Histamine Release From Rat Mast Cells and Lung Fragments. Arzneimittelforschung. 1988;38(1):75-9. PubMed PMID: 2452639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 2nd communication: inhibitory effects on histamine release from rat mast cells and lung fragments. AU - Yanagihara,Y, AU - Abe,T, AU - Kuroda,T, AU - Shida,T, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 75 EP - 9 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 38 IS - 1 N2 - The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on its ability to inhibit histamine release from both peritoneal mast cells and lung fragments of rats were investigated. WP-833 inhibited in a dose-dependent fashion immunoglobulin E (IgE)-mediated histamine release from mast cells. Such potent inhibition was observed in glucose-free as well as complete Tyrode's solution but neither in Ca2+-free nor D2O-supplemented Tyrode's solution. In addition, WP-833 significantly increased intracellular cyclic adenosine monophosphate (AMP) levels in purified mast cells. On the other hand, WP-833 inhibited compound 48/80-but not calcium ionophore A23187-induced histamine release from normal mast cells. Also both IgE- and IgG-mediated histamine release from lung fragments were inhibited by WP-833. WP-833 showed non-competitive inhibition of cyclic AMP-dependent phosphodiesterase derived from lung preparations. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/2452639/Immunopharmacological_actions_of_the_new_antiallergic_drug_butyl_3'__1H_tetrazol_5_yl_oxanilate__2nd_communication:_inhibitory_effects_on_histamine_release_from_rat_mast_cells_and_lung_fragments_ DB - PRIME DP - Unbound Medicine ER -