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Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 4th communication: effects on histamine release from human leukocytes and from human and monkey lung fragments.
Arzneimittelforschung. 1988 Jan; 38(1):84-7.A

Abstract

The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on histamine release from human leukocytes and from human and monkey lung fragments were investigated. WP-833 showed no inhibition of antigen, anti-immunoglobulin E (IgE)- and calcium ionophore A23187-induced histamine release from leukocytes of atopic patients allergic to house dust mite. In addition, no influences of WP-833 on the levels of cyclic adenosine monophosphate and guanosine monophosphate in leukocytes from healthy subjects were observed. However, antigen- or anti-IgE-mediated histamine release from human and monkey lung fragments passively sensitized in vitro with human serum IgE sensitive to mite antigen was clearly inhibited by WP-833. Interestingly, prolonged pretreatment of lung fragments with WP-833 resulted in a decay in inhibition of anaphylactic histamine release. Spontaneous histamine release from human leukocytes and monkey lung fragments were not inhibited by WP-833.

Authors+Show Affiliations

Clinical Research Center for Allergy, National Sagamihara Hospital, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2452641

Citation

Yanagihara, Y, et al. "Immunopharmacological Actions of the New Antiallergic Drug Butyl 3'-(1H-tetrazol-5-yl)oxanilate. 4th Communication: Effects On Histamine Release From Human Leukocytes and From Human and Monkey Lung Fragments." Arzneimittel-Forschung, vol. 38, no. 1, 1988, pp. 84-7.
Yanagihara Y, Abe T, Tsuriya Y, et al. Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 4th communication: effects on histamine release from human leukocytes and from human and monkey lung fragments. Arzneimittelforschung. 1988;38(1):84-7.
Yanagihara, Y., Abe, T., Tsuriya, Y., Kuroda, T., & Shida, T. (1988). Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 4th communication: effects on histamine release from human leukocytes and from human and monkey lung fragments. Arzneimittel-Forschung, 38(1), 84-7.
Yanagihara Y, et al. Immunopharmacological Actions of the New Antiallergic Drug Butyl 3'-(1H-tetrazol-5-yl)oxanilate. 4th Communication: Effects On Histamine Release From Human Leukocytes and From Human and Monkey Lung Fragments. Arzneimittelforschung. 1988;38(1):84-7. PubMed PMID: 2452641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 4th communication: effects on histamine release from human leukocytes and from human and monkey lung fragments. AU - Yanagihara,Y, AU - Abe,T, AU - Tsuriya,Y, AU - Kuroda,T, AU - Shida,T, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 84 EP - 7 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 38 IS - 1 N2 - The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on histamine release from human leukocytes and from human and monkey lung fragments were investigated. WP-833 showed no inhibition of antigen, anti-immunoglobulin E (IgE)- and calcium ionophore A23187-induced histamine release from leukocytes of atopic patients allergic to house dust mite. In addition, no influences of WP-833 on the levels of cyclic adenosine monophosphate and guanosine monophosphate in leukocytes from healthy subjects were observed. However, antigen- or anti-IgE-mediated histamine release from human and monkey lung fragments passively sensitized in vitro with human serum IgE sensitive to mite antigen was clearly inhibited by WP-833. Interestingly, prolonged pretreatment of lung fragments with WP-833 resulted in a decay in inhibition of anaphylactic histamine release. Spontaneous histamine release from human leukocytes and monkey lung fragments were not inhibited by WP-833. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/2452641/Immunopharmacological_actions_of_the_new_antiallergic_drug_butyl_3'__1H_tetrazol_5_yl_oxanilate__4th_communication:_effects_on_histamine_release_from_human_leukocytes_and_from_human_and_monkey_lung_fragments_ DB - PRIME DP - Unbound Medicine ER -