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Retinal microstructural changes in eyes with resolved branch retinal vein occlusion: an adaptive optics scanning laser ophthalmoscopy study.
Am J Ophthalmol. 2014 Jun; 157(6):1239-1249.e3.AJ

Abstract

PURPOSE

To assess macular photoreceptor abnormalities in eyes with resolved branch retinal vein occlusion (BRVO) using adaptive optics scanning laser ophthalmoscopy (AO-SLO).

DESIGN

Prospective observational cross-sectional case series.

METHODS

After complete resolution of macular edema and retinal hemorrhage, 21 eyes (21 patients) with BRVO underwent full ophthalmologic examination and imaging with optical coherence tomography (OCT) and a prototype AO-SLO system. Cone density and spatial mosaic organization were assessed using AO-SLO images.

RESULTS

Regular parafoveal cone mosaic patterns were clearly visualized with the prototype AO-SLO imaging system in the BRVO-unaffected side. However, in the side of the retina previously affected by the BRVO, cone mosaic patterns were disorganized and dark regions missing wave-guiding cones were apparent. Additionally, retinal capillaries were dilated, no longer had a uniform caliber, and had less direct paths through the retina. In the affected side, parafoveal cone density was significantly decreased, compared with the corresponding retinal area on the unaffected side (P < .001). Furthermore, the hexagonal Voronoi domain ratio and the nearest-neighbor distances were significantly lower than in the unaffected side (P < .05). These parameters were also correlated with photoreceptor layer integrity in the parafovea.

CONCLUSIONS

After BRVO-associated retinal hemorrhage and macular edema resolved, affected parafoveal cone density decreases and the cone mosaic spatial arrangement is disrupted, becoming more irregular. These cone microstructural abnormalities may extend to parafovea in the BRVO-unaffected side.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: tujikawa@kuhp.kyoto-u.ac.jp.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24531026

Citation

Akagi-Kurashige, Yumiko, et al. "Retinal Microstructural Changes in Eyes With Resolved Branch Retinal Vein Occlusion: an Adaptive Optics Scanning Laser Ophthalmoscopy Study." American Journal of Ophthalmology, vol. 157, no. 6, 2014, pp. 1239-1249.e3.
Akagi-Kurashige Y, Tsujikawa A, Ooto S, et al. Retinal microstructural changes in eyes with resolved branch retinal vein occlusion: an adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol. 2014;157(6):1239-1249.e3.
Akagi-Kurashige, Y., Tsujikawa, A., Ooto, S., Makiyama, Y., Muraoka, Y., Kumagai, K., Uji, A., Arichika, S., Murakami, T., Miyamoto, K., & Yoshimura, N. (2014). Retinal microstructural changes in eyes with resolved branch retinal vein occlusion: an adaptive optics scanning laser ophthalmoscopy study. American Journal of Ophthalmology, 157(6), 1239-e3. https://doi.org/10.1016/j.ajo.2014.02.026
Akagi-Kurashige Y, et al. Retinal Microstructural Changes in Eyes With Resolved Branch Retinal Vein Occlusion: an Adaptive Optics Scanning Laser Ophthalmoscopy Study. Am J Ophthalmol. 2014;157(6):1239-1249.e3. PubMed PMID: 24531026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal microstructural changes in eyes with resolved branch retinal vein occlusion: an adaptive optics scanning laser ophthalmoscopy study. AU - Akagi-Kurashige,Yumiko, AU - Tsujikawa,Akitaka, AU - Ooto,Sotaro, AU - Makiyama,Yukiko, AU - Muraoka,Yuki, AU - Kumagai,Kyoko, AU - Uji,Akihito, AU - Arichika,Shigeta, AU - Murakami,Tomoaki, AU - Miyamoto,Kazuaki, AU - Yoshimura,Nagahisa, Y1 - 2014/02/14/ PY - 2013/11/25/received PY - 2014/02/10/revised PY - 2014/02/10/accepted PY - 2014/2/18/entrez PY - 2014/2/18/pubmed PY - 2014/8/2/medline SP - 1239 EP - 1249.e3 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 157 IS - 6 N2 - PURPOSE: To assess macular photoreceptor abnormalities in eyes with resolved branch retinal vein occlusion (BRVO) using adaptive optics scanning laser ophthalmoscopy (AO-SLO). DESIGN: Prospective observational cross-sectional case series. METHODS: After complete resolution of macular edema and retinal hemorrhage, 21 eyes (21 patients) with BRVO underwent full ophthalmologic examination and imaging with optical coherence tomography (OCT) and a prototype AO-SLO system. Cone density and spatial mosaic organization were assessed using AO-SLO images. RESULTS: Regular parafoveal cone mosaic patterns were clearly visualized with the prototype AO-SLO imaging system in the BRVO-unaffected side. However, in the side of the retina previously affected by the BRVO, cone mosaic patterns were disorganized and dark regions missing wave-guiding cones were apparent. Additionally, retinal capillaries were dilated, no longer had a uniform caliber, and had less direct paths through the retina. In the affected side, parafoveal cone density was significantly decreased, compared with the corresponding retinal area on the unaffected side (P < .001). Furthermore, the hexagonal Voronoi domain ratio and the nearest-neighbor distances were significantly lower than in the unaffected side (P < .05). These parameters were also correlated with photoreceptor layer integrity in the parafovea. CONCLUSIONS: After BRVO-associated retinal hemorrhage and macular edema resolved, affected parafoveal cone density decreases and the cone mosaic spatial arrangement is disrupted, becoming more irregular. These cone microstructural abnormalities may extend to parafovea in the BRVO-unaffected side. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/24531026/Retinal_microstructural_changes_in_eyes_with_resolved_branch_retinal_vein_occlusion:_an_adaptive_optics_scanning_laser_ophthalmoscopy_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(14)00090-7 DB - PRIME DP - Unbound Medicine ER -