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Interaction of citrate-coated silver nanoparticles with earthworm coelomic fluid and related cytotoxicity in Eisenia andrei.
J Appl Toxicol. 2014 Nov; 34(11):1145-54.JA

Abstract

Understanding the interaction of nanoparticles with biological fluid is important for predicting the behavior and toxicity of nanoparticles in living systems. The earthworm Eisenia andrei was exposed to citrate-coated silver nanoparticles (cAgNPs), and the interaction of cAgNPs with earthworm coelomic fluid (ECF), the cytotoxicity of cAgNPs in earthworm coelomocytes was assessed. The neutral red retention assay showed a reduction in lysosomal stability after exposure. The toxicity of silver ions dissolved from cAgNPs in the soil medium was not significant. The aggregation and dissolution of cAgNPs increased in ECF, which contains various electrolytes that alter the properties of nanoparticles, and their subsequent toxicity. Microscopic and dissolution studies demonstrated that the aggregation of cAgNPs rapidly increased, and readily dissolved in ECF. The bioavailability of cAgNPs to earthworms induced lysosomal cytotoxicity. This is the first report to test the interaction and lysosomal cytotoxicity of nanoparticles in earthworm biofluids.

Authors+Show Affiliations

Department of Environmental Health Science, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24532537

Citation

Kwak, Jin Il, et al. "Interaction of Citrate-coated Silver Nanoparticles With Earthworm Coelomic Fluid and Related Cytotoxicity in Eisenia Andrei." Journal of Applied Toxicology : JAT, vol. 34, no. 11, 2014, pp. 1145-54.
Kwak JI, Lee WM, Kim SW, et al. Interaction of citrate-coated silver nanoparticles with earthworm coelomic fluid and related cytotoxicity in Eisenia andrei. J Appl Toxicol. 2014;34(11):1145-54.
Kwak, J. I., Lee, W. M., Kim, S. W., & An, Y. J. (2014). Interaction of citrate-coated silver nanoparticles with earthworm coelomic fluid and related cytotoxicity in Eisenia andrei. Journal of Applied Toxicology : JAT, 34(11), 1145-54. https://doi.org/10.1002/jat.2993
Kwak JI, et al. Interaction of Citrate-coated Silver Nanoparticles With Earthworm Coelomic Fluid and Related Cytotoxicity in Eisenia Andrei. J Appl Toxicol. 2014;34(11):1145-54. PubMed PMID: 24532537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of citrate-coated silver nanoparticles with earthworm coelomic fluid and related cytotoxicity in Eisenia andrei. AU - Kwak,Jin Il, AU - Lee,Woo-Mi, AU - Kim,Shin Woong, AU - An,Youn-Joo, Y1 - 2014/02/16/ PY - 2013/07/02/received PY - 2013/12/24/revised PY - 2013/12/24/accepted PY - 2014/2/18/entrez PY - 2014/2/18/pubmed PY - 2015/6/20/medline KW - Eisenia andrei, biofluid KW - cytotoxicity KW - earthworm coelomic fluid KW - silver nanoparticle SP - 1145 EP - 54 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 34 IS - 11 N2 - Understanding the interaction of nanoparticles with biological fluid is important for predicting the behavior and toxicity of nanoparticles in living systems. The earthworm Eisenia andrei was exposed to citrate-coated silver nanoparticles (cAgNPs), and the interaction of cAgNPs with earthworm coelomic fluid (ECF), the cytotoxicity of cAgNPs in earthworm coelomocytes was assessed. The neutral red retention assay showed a reduction in lysosomal stability after exposure. The toxicity of silver ions dissolved from cAgNPs in the soil medium was not significant. The aggregation and dissolution of cAgNPs increased in ECF, which contains various electrolytes that alter the properties of nanoparticles, and their subsequent toxicity. Microscopic and dissolution studies demonstrated that the aggregation of cAgNPs rapidly increased, and readily dissolved in ECF. The bioavailability of cAgNPs to earthworms induced lysosomal cytotoxicity. This is the first report to test the interaction and lysosomal cytotoxicity of nanoparticles in earthworm biofluids. SN - 1099-1263 UR - https://www.unboundmedicine.com/medline/citation/24532537/Interaction_of_citrate_coated_silver_nanoparticles_with_earthworm_coelomic_fluid_and_related_cytotoxicity_in_Eisenia_andrei_ L2 - https://doi.org/10.1002/jat.2993 DB - PRIME DP - Unbound Medicine ER -