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Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study.
Epilepsy Res. 2014 Mar; 108(3):468-80.ER

Abstract

PURPOSE

The present study aims to determine the initialization and propagation of typical absence seizures using magnetoencephalography (MEG).

METHOD

Fourteen drug-naïve children with childhood absence epilepsy (CAE) were studied using a 275-Channel MEG system. The spectral signatures of epileptic activity were assessed using Morlet continuous wavelet transform. Magnetic sources were volumetrically localized using dynamic magnetic source imaging (dMSI) with a slide window at a millisecond temporal resolution.

RESULT

The initial portion of ictal activity was predominantly located to the left frontal and posterior cortices. The frontal sources were in the left medial prefrontal cortex (MPFC), the pre-supplementary motor area (pre-SMA), the primary motor cortex, and the lateral prefrontal cortex. The posterior cortical sources were predominantly localized to the left precuneus (pC) and the medial occipital cortices (MOC). The ictal activity after the initialization showed involvement of the MPFC and pC of all patients (14/14) and recursive propagation between the frontal (MPFC) and posterior cortices (pC and MOC) via either the medial portion of the brain (9/14) or the thalamus (5/14), respectively.

CONCLUSION

The left frontal and posterior (pC and MOC) cortices play a key role in the initialization of epileptic activity in absence seizures. The thalamus plays a key role in the propagation of absence seizures between the frontal and posterior cortical sources. Considering the MPFC and pC are the nodes of the default mode network (DMN), our results support involvement of the DMN in absence seizures.

Authors+Show Affiliations

Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45220, USA.Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.Department of Neurology, Nanjing Children's Hospital, Nanjing, Jiangsu 210029, China.Department of Neurology, Nanjing Children's Hospital, Nanjing, Jiangsu 210029, China.Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address: lidou2005@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24534760

Citation

Miao, Ailiang, et al. "Dynamic Magnetic Source Imaging of Absence Seizure Initialization and Propagation: a Magnetoencephalography Study." Epilepsy Research, vol. 108, no. 3, 2014, pp. 468-80.
Miao A, Tang L, Xiang J, et al. Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study. Epilepsy Res. 2014;108(3):468-80.
Miao, A., Tang, L., Xiang, J., Guan, Q., Ge, H., Liu, H., Wu, T., Chen, Q., Yang, L., Lu, X., Hu, Z., & Wang, X. (2014). Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study. Epilepsy Research, 108(3), 468-80. https://doi.org/10.1016/j.eplepsyres.2014.01.006
Miao A, et al. Dynamic Magnetic Source Imaging of Absence Seizure Initialization and Propagation: a Magnetoencephalography Study. Epilepsy Res. 2014;108(3):468-80. PubMed PMID: 24534760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study. AU - Miao,Ailiang, AU - Tang,Lu, AU - Xiang,Jing, AU - Guan,Qingshan, AU - Ge,Huaiting, AU - Liu,Hongxing, AU - Wu,Ting, AU - Chen,Qiqi, AU - Yang,Lu, AU - Lu,Xiaopeng, AU - Hu,Zheng, AU - Wang,Xiaoshan, Y1 - 2014/01/29/ PY - 2013/06/04/received PY - 2013/11/20/revised PY - 2014/01/14/accepted PY - 2014/2/19/entrez PY - 2014/2/19/pubmed PY - 2014/10/31/medline KW - Childhood absence epilepsy KW - Default nodes KW - Dynamic magnetic source imaging KW - Magnetoencephalography KW - Real-time spectrograms KW - Spike and wave discharges SP - 468 EP - 80 JF - Epilepsy research JO - Epilepsy Res. VL - 108 IS - 3 N2 - PURPOSE: The present study aims to determine the initialization and propagation of typical absence seizures using magnetoencephalography (MEG). METHOD: Fourteen drug-naïve children with childhood absence epilepsy (CAE) were studied using a 275-Channel MEG system. The spectral signatures of epileptic activity were assessed using Morlet continuous wavelet transform. Magnetic sources were volumetrically localized using dynamic magnetic source imaging (dMSI) with a slide window at a millisecond temporal resolution. RESULT: The initial portion of ictal activity was predominantly located to the left frontal and posterior cortices. The frontal sources were in the left medial prefrontal cortex (MPFC), the pre-supplementary motor area (pre-SMA), the primary motor cortex, and the lateral prefrontal cortex. The posterior cortical sources were predominantly localized to the left precuneus (pC) and the medial occipital cortices (MOC). The ictal activity after the initialization showed involvement of the MPFC and pC of all patients (14/14) and recursive propagation between the frontal (MPFC) and posterior cortices (pC and MOC) via either the medial portion of the brain (9/14) or the thalamus (5/14), respectively. CONCLUSION: The left frontal and posterior (pC and MOC) cortices play a key role in the initialization of epileptic activity in absence seizures. The thalamus plays a key role in the propagation of absence seizures between the frontal and posterior cortical sources. Considering the MPFC and pC are the nodes of the default mode network (DMN), our results support involvement of the DMN in absence seizures. SN - 1872-6844 UR - https://www.unboundmedicine.com/medline/citation/24534760/Dynamic_magnetic_source_imaging_of_absence_seizure_initialization_and_propagation:_a_magnetoencephalography_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-1211(14)00019-9 DB - PRIME DP - Unbound Medicine ER -