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Gender differences in GH response to GHRH+ARG in lipodystrophic patients with HIV: a key role for body fat distribution.
Eur J Endocrinol 2014; 170(5):685-96EJ

Abstract

OBJECTIVE

Gender influence on GH secretion in human immunodeficiency virus (HIV)-infected patients is poorly known.

DESIGN AND METHODS

To determine the effect of gender, we compared GH response to GH-releasing hormone plus arginine (GHRH+Arg), and body composition in 103 men and 97 women with HIV and lipodystrophy. The main outcomes were IGF1, basal GH, GH peak and area under the curve (AUC) after GHRH+Arg, body composition, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT).

RESULTS

Men had lower GH peak and AUC than women (P<0.001). Of the study population, 21% of women and 37% of men had biochemical GH deficiency (GHD; GH peak <7.5 μg/l). VAT-to-SAT ratio was higher in men than in women with GHD (P<0.05). Unlike women, VAT, SAT, and trunk fat were greater in men with GHD than in men without GHD. IGF1 was significantly lower in women with GHD than in women without GHD, but not in men. At univariate analysis, BMI, trunk fat mass, VAT, and total adipose tissue were associated with GH peak and AUC in both sexes (P<0.05). BMI was the most significant predictive factor of GH peak, and AUC at multiregression analysis. Overall, abdominal fat had a less pronounced effect on GH in females than in males.

CONCLUSIONS

These data demonstrate that GH response to GHRH+Arg is significantly lower in HIV-infected males than females, resulting in a higher percentage of GHD in men. Adipose tissue distribution more than fat mass per se seems to account for GH gender differences and for the alteration of GH-IGF1 status in these patients.

Authors+Show Affiliations

Chair of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24536088

Citation

Brigante, Giulia, et al. "Gender Differences in GH Response to GHRH+ARG in Lipodystrophic Patients With HIV: a Key Role for Body Fat Distribution." European Journal of Endocrinology, vol. 170, no. 5, 2014, pp. 685-96.
Brigante G, Diazzi C, Ansaloni A, et al. Gender differences in GH response to GHRH+ARG in lipodystrophic patients with HIV: a key role for body fat distribution. Eur J Endocrinol. 2014;170(5):685-96.
Brigante, G., Diazzi, C., Ansaloni, A., Zirilli, L., Orlando, G., Guaraldi, G., & Rochira, V. (2014). Gender differences in GH response to GHRH+ARG in lipodystrophic patients with HIV: a key role for body fat distribution. European Journal of Endocrinology, 170(5), pp. 685-96. doi:10.1530/EJE-13-0961.
Brigante G, et al. Gender Differences in GH Response to GHRH+ARG in Lipodystrophic Patients With HIV: a Key Role for Body Fat Distribution. Eur J Endocrinol. 2014;170(5):685-96. PubMed PMID: 24536088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender differences in GH response to GHRH+ARG in lipodystrophic patients with HIV: a key role for body fat distribution. AU - Brigante,Giulia, AU - Diazzi,Chiara, AU - Ansaloni,Anna, AU - Zirilli,Lucia, AU - Orlando,Gabriella, AU - Guaraldi,Giovanni, AU - Rochira,Vincenzo, Y1 - 2014/04/10/ PY - 2014/2/19/entrez PY - 2014/2/19/pubmed PY - 2014/6/11/medline SP - 685 EP - 96 JF - European journal of endocrinology JO - Eur. J. Endocrinol. VL - 170 IS - 5 N2 - OBJECTIVE: Gender influence on GH secretion in human immunodeficiency virus (HIV)-infected patients is poorly known. DESIGN AND METHODS: To determine the effect of gender, we compared GH response to GH-releasing hormone plus arginine (GHRH+Arg), and body composition in 103 men and 97 women with HIV and lipodystrophy. The main outcomes were IGF1, basal GH, GH peak and area under the curve (AUC) after GHRH+Arg, body composition, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). RESULTS: Men had lower GH peak and AUC than women (P<0.001). Of the study population, 21% of women and 37% of men had biochemical GH deficiency (GHD; GH peak <7.5 μg/l). VAT-to-SAT ratio was higher in men than in women with GHD (P<0.05). Unlike women, VAT, SAT, and trunk fat were greater in men with GHD than in men without GHD. IGF1 was significantly lower in women with GHD than in women without GHD, but not in men. At univariate analysis, BMI, trunk fat mass, VAT, and total adipose tissue were associated with GH peak and AUC in both sexes (P<0.05). BMI was the most significant predictive factor of GH peak, and AUC at multiregression analysis. Overall, abdominal fat had a less pronounced effect on GH in females than in males. CONCLUSIONS: These data demonstrate that GH response to GHRH+Arg is significantly lower in HIV-infected males than females, resulting in a higher percentage of GHD in men. Adipose tissue distribution more than fat mass per se seems to account for GH gender differences and for the alteration of GH-IGF1 status in these patients. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/24536088/Gender_differences_in_GH_response_to_GHRH+ARG_in_lipodystrophic_patients_with_HIV:_a_key_role_for_body_fat_distribution_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-13-0961 DB - PRIME DP - Unbound Medicine ER -