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Treponema pallidum in leukoderma syphiliticum demonstrated by electron microscopy.
Acta Derm Venereol. 1988; 68(2):102-6.AD

Abstract

Punch biopsies from syphilitic leukoderma lesions and from unaffected skin in 3 patients with secondary syphilis were studies in the transmission electron microscope. In one of the patients the pigment disorder was not preceded by any visible syphilids, and in the biopsy from the leukodermal skin in this patient Treponemata pallidium were demonstrated around vessels and inside nerve fibres in which the myelin sheaths of the axons showed evidence of degeneration. In the other 2 patients the depigmented areas appeared while macular and papular syphilitic lesions were healing. In the biopsies from the leukodermal lesions of these 2 patients and from unaffected skin of all 3 patients, no treponemes were demonstrated. The study indicates that syphilitic leukoderma is not invariably a post-inflammatory phenomenon, but the pigmented skin lesions may themselves represent stigmata of an active syphilitic infection.

Authors+Show Affiliations

Department of Dermatology, University of Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2453987

Citation

Poulsen, A, et al. "Treponema Pallidum in Leukoderma Syphiliticum Demonstrated By Electron Microscopy." Acta Dermato-venereologica, vol. 68, no. 2, 1988, pp. 102-6.
Poulsen A, Secher L, Kobayasi T, et al. Treponema pallidum in leukoderma syphiliticum demonstrated by electron microscopy. Acta Derm Venereol. 1988;68(2):102-6.
Poulsen, A., Secher, L., Kobayasi, T., & Weismann, K. (1988). Treponema pallidum in leukoderma syphiliticum demonstrated by electron microscopy. Acta Dermato-venereologica, 68(2), 102-6.
Poulsen A, et al. Treponema Pallidum in Leukoderma Syphiliticum Demonstrated By Electron Microscopy. Acta Derm Venereol. 1988;68(2):102-6. PubMed PMID: 2453987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treponema pallidum in leukoderma syphiliticum demonstrated by electron microscopy. AU - Poulsen,A, AU - Secher,L, AU - Kobayasi,T, AU - Weismann,K, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 102 EP - 6 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 68 IS - 2 N2 - Punch biopsies from syphilitic leukoderma lesions and from unaffected skin in 3 patients with secondary syphilis were studies in the transmission electron microscope. In one of the patients the pigment disorder was not preceded by any visible syphilids, and in the biopsy from the leukodermal skin in this patient Treponemata pallidium were demonstrated around vessels and inside nerve fibres in which the myelin sheaths of the axons showed evidence of degeneration. In the other 2 patients the depigmented areas appeared while macular and papular syphilitic lesions were healing. In the biopsies from the leukodermal lesions of these 2 patients and from unaffected skin of all 3 patients, no treponemes were demonstrated. The study indicates that syphilitic leukoderma is not invariably a post-inflammatory phenomenon, but the pigmented skin lesions may themselves represent stigmata of an active syphilitic infection. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/2453987/Treponema_pallidum_in_leukoderma_syphiliticum_demonstrated_by_electron_microscopy_ DB - PRIME DP - Unbound Medicine ER -