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Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells.
Arch Dermatol Res. 1988; 280(3):158-62.AD

Abstract

Substance P is known to be a potent histamine liberator for mast cells. The influence of antianaphylactic agents, disodium cromoglycate (DSCG), ketotifen, and tranilast was studied on substance-P and compound 48/80-induced histamine release from rat peritoneal mast cells. Substance-P induced histamine release was inhibited by these agents, while compound 48/80-induced histamine release was not inhibited by tranilast. Our findings suggest that these antianaphylactic agents are assumed to be effective for cutaneous diseases which might be concerned with substance P and histamine.

Authors+Show Affiliations

Hachisuka H
Department of Dermatology, Kurume University School of Medicine, Japan.
Nomura H
No affiliation info available
Sakamoto F
No affiliation info available
Mori O
No affiliation info available
Okubo K
No affiliation info available
Sasai Y
No affiliation info available

MeSH

AnimalsCromolyn SodiumDepression, ChemicalFemaleHistamine ReleaseKetotifenMaleMast CellsPeritoneal CavityRatsRats, Inbred StrainsSubstance Portho-Aminobenzoatesp-Methoxy-N-methylphenethylamine

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2454082

Citation

Hachisuka, H, et al. "Effect of Antianaphylactic Agents On substance-P Induced Histamine Release From Rat Peritoneal Mast Cells." Archives of Dermatological Research, vol. 280, no. 3, 1988, pp. 158-62.
Hachisuka H, Nomura H, Sakamoto F, et al. Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells. Arch Dermatol Res. 1988;280(3):158-62.
Hachisuka, H., Nomura, H., Sakamoto, F., Mori, O., Okubo, K., & Sasai, Y. (1988). Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells. Archives of Dermatological Research, 280(3), 158-62.
Hachisuka H, et al. Effect of Antianaphylactic Agents On substance-P Induced Histamine Release From Rat Peritoneal Mast Cells. Arch Dermatol Res. 1988;280(3):158-62. PubMed PMID: 2454082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells. AU - Hachisuka,H, AU - Nomura,H, AU - Sakamoto,F, AU - Mori,O, AU - Okubo,K, AU - Sasai,Y, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 158 EP - 62 JF - Archives of dermatological research JO - Arch Dermatol Res VL - 280 IS - 3 N2 - Substance P is known to be a potent histamine liberator for mast cells. The influence of antianaphylactic agents, disodium cromoglycate (DSCG), ketotifen, and tranilast was studied on substance-P and compound 48/80-induced histamine release from rat peritoneal mast cells. Substance-P induced histamine release was inhibited by these agents, while compound 48/80-induced histamine release was not inhibited by tranilast. Our findings suggest that these antianaphylactic agents are assumed to be effective for cutaneous diseases which might be concerned with substance P and histamine. SN - 0340-3696 UR - https://www.unboundmedicine.com/medline/citation/2454082/Effect_of_antianaphylactic_agents_on_substance_P_induced_histamine_release_from_rat_peritoneal_mast_cells_ DB - PRIME DP - Unbound Medicine ER -