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Metabolic syndrome and chronic kidney disease in a Southern Chinese population.
Nephrology (Carlton) 2014; 19(6):325-31N

Abstract

AIM

To explore the relationship between metabolic syndrome (MS) and risk for chronic kidney disease (CKD) in a Southern Chinese population.

METHODS

A cross-sectional study was conducted in 1724 community-based Southern Chinese participants from June to October 2012. The prevalence of MS (as defined by the International Diabetes Federation) and CKD (defined as an estimated glomerular filtration rate of <60 mL/min per 1.73 m(2) and/or albuminuria) was determined. The association between MS and CKD was then analyzed using STATA software.

RESULTS

Metabolic syndrome was significantly associated with CKD (P < 0.001) in the unadjusted analyses as well as after adjustment for potential confounders. The unadjusted odds ratio and adjusted odds ratio for MS were 3.53 (95% confidence interval (CI) 2.62 to 4.75, P < 0.001) and 2.52 (95% CI 1.84 to 3.54, P < 0.001). When further adjusted for diabetes and hypertension, the association of MS and CKD was significant (odds ratio (OR) 1.63, 95% CI 1.15 to 2.32, P = 0.006). After adjustment for potential confounders, three components and four/five components were associated with CKD. The OR for three components and four/five components were 2.90 (95% CI 1.70 to 4.96, P < 0.001) and 3.64(95% CI 1.95 to 6.80, P < 0.001), when compared with those without components. High blood pressure, high serum triglyceride level, elevated fasting glucose level and central obesity were associated with CKD (P < 0.05). The odds ratios for elevated blood pressure, elevated serum triglyceride levels, elevated fasting glucose and central obesity were 1.80 (95% CI 1.25 to 2.62, P = 0.002), 1.56 (95% CI 1.14 to 2.14, P = 0.006), 2.54 (95% CI 1.82 to 3.57, P < 0.001), and 1.50 (95% CI 1.10 to 2.07, P = 0.01), respectively.

CONCLUSION

These findings suggest that MS is associated with CKD in Southern Chinese population, which may provide important information for the overall control of these diseases.

Authors+Show Affiliations

Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24548104

Citation

Li, Yongqiang, et al. "Metabolic Syndrome and Chronic Kidney Disease in a Southern Chinese Population." Nephrology (Carlton, Vic.), vol. 19, no. 6, 2014, pp. 325-31.
Li Y, Chen Y, Liu X, et al. Metabolic syndrome and chronic kidney disease in a Southern Chinese population. Nephrology (Carlton). 2014;19(6):325-31.
Li, Y., Chen, Y., Liu, X., Liang, Y., Shao, X., Zhang, Y., ... Zou, H. (2014). Metabolic syndrome and chronic kidney disease in a Southern Chinese population. Nephrology (Carlton, Vic.), 19(6), pp. 325-31. doi:10.1111/nep.12219.
Li Y, et al. Metabolic Syndrome and Chronic Kidney Disease in a Southern Chinese Population. Nephrology (Carlton). 2014;19(6):325-31. PubMed PMID: 24548104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and chronic kidney disease in a Southern Chinese population. AU - Li,Yongqiang, AU - Chen,Youming, AU - Liu,Xinyu, AU - Liang,Yan, AU - Shao,Xiaofei, AU - Zhang,Ying, AU - Wang,Honglei, AU - Wang,Xiaohong, AU - Li,Bin, AU - Deng,Kangping, AU - Liu,Qin, AU - Holthöfer,Harry, AU - Liu,Hongmei, AU - Zou,Hequn, PY - 2014/02/10/accepted PY - 2014/2/20/entrez PY - 2014/2/20/pubmed PY - 2015/1/6/medline KW - Southern Chinese population KW - chronic kidney disease KW - metabolic syndrome SP - 325 EP - 31 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 19 IS - 6 N2 - AIM: To explore the relationship between metabolic syndrome (MS) and risk for chronic kidney disease (CKD) in a Southern Chinese population. METHODS: A cross-sectional study was conducted in 1724 community-based Southern Chinese participants from June to October 2012. The prevalence of MS (as defined by the International Diabetes Federation) and CKD (defined as an estimated glomerular filtration rate of <60 mL/min per 1.73 m(2) and/or albuminuria) was determined. The association between MS and CKD was then analyzed using STATA software. RESULTS: Metabolic syndrome was significantly associated with CKD (P < 0.001) in the unadjusted analyses as well as after adjustment for potential confounders. The unadjusted odds ratio and adjusted odds ratio for MS were 3.53 (95% confidence interval (CI) 2.62 to 4.75, P < 0.001) and 2.52 (95% CI 1.84 to 3.54, P < 0.001). When further adjusted for diabetes and hypertension, the association of MS and CKD was significant (odds ratio (OR) 1.63, 95% CI 1.15 to 2.32, P = 0.006). After adjustment for potential confounders, three components and four/five components were associated with CKD. The OR for three components and four/five components were 2.90 (95% CI 1.70 to 4.96, P < 0.001) and 3.64(95% CI 1.95 to 6.80, P < 0.001), when compared with those without components. High blood pressure, high serum triglyceride level, elevated fasting glucose level and central obesity were associated with CKD (P < 0.05). The odds ratios for elevated blood pressure, elevated serum triglyceride levels, elevated fasting glucose and central obesity were 1.80 (95% CI 1.25 to 2.62, P = 0.002), 1.56 (95% CI 1.14 to 2.14, P = 0.006), 2.54 (95% CI 1.82 to 3.57, P < 0.001), and 1.50 (95% CI 1.10 to 2.07, P = 0.01), respectively. CONCLUSION: These findings suggest that MS is associated with CKD in Southern Chinese population, which may provide important information for the overall control of these diseases. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/24548104/Metabolic_syndrome_and_chronic_kidney_disease_in_a_Southern_Chinese_population_ L2 - https://doi.org/10.1111/nep.12219 DB - PRIME DP - Unbound Medicine ER -