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Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the Framingham Heart Study.
Obesity (Silver Spring). 2014 May; 22(5):E157-63.O

Abstract

OBJECTIVE

The purpose of this study was to examine the relationship between usual sugar-sweetened beverage (SSB) consumption and prevalence of abnormal metabolic health across body mass index (BMI) categories.

METHODS

The metabolic health of 6,842 non-diabetic adults was classified using cross-sectional data from the Framingham Heart Study Offspring (1998-2001) and Third Generation (2002-2005) cohorts. Adults were classified as normal weight, overweight or obese and, within these categories, metabolic health was defined based on five criteria-hypertension, elevated fasting glucose, elevated triglycerides, low HDL cholesterol, and insulin resistance. Individuals without metabolic abnormalities were considered metabolically healthy. Logistic regression was used to examine the associations between categories of SSB consumption and risk of metabolic health after stratification by BMI.

RESULTS

Comparing the highest category of SSB consumers (median of 7 SSB per week) to the lowest category (non-consumers), odds ratios (95% confidence intervals) for metabolically abnormal phenotypes, compared to the metabolically normal, were 1.9 (1.1-3.4) among the obese, 2.0 (1.4-2.9) among the overweight, and 1.9 (1.4-2.6) among the normal weight individuals.

CONCLUSIONS

In this cross-sectional analysis, it is observed that, irrespective of weight status, consumers of SSB were more likely to display metabolic abnormalities compared to non-consumers in a dose-dependent manner.

Authors+Show Affiliations

Tufts University Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24550031

Citation

Green, Angela K., et al. "Sugar-sweetened Beverages and Prevalence of the Metabolically Abnormal Phenotype in the Framingham Heart Study." Obesity (Silver Spring, Md.), vol. 22, no. 5, 2014, pp. E157-63.
Green AK, Jacques PF, Rogers G, et al. Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the Framingham Heart Study. Obesity (Silver Spring). 2014;22(5):E157-63.
Green, A. K., Jacques, P. F., Rogers, G., Fox, C. S., Meigs, J. B., & McKeown, N. M. (2014). Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the Framingham Heart Study. Obesity (Silver Spring, Md.), 22(5), E157-63. https://doi.org/10.1002/oby.20724
Green AK, et al. Sugar-sweetened Beverages and Prevalence of the Metabolically Abnormal Phenotype in the Framingham Heart Study. Obesity (Silver Spring). 2014;22(5):E157-63. PubMed PMID: 24550031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the Framingham Heart Study. AU - Green,Angela K, AU - Jacques,Paul F, AU - Rogers,Gail, AU - Fox,Caroline S, AU - Meigs,James B, AU - McKeown,Nicola M, Y1 - 2014/03/08/ PY - 2013/07/23/received PY - 2014/02/06/revised PY - 2014/02/14/accepted PY - 2014/2/20/entrez PY - 2014/2/20/pubmed PY - 2015/1/3/medline KW - Obesity KW - chronic disease KW - metabolically healthy obese phenotype KW - sugar-sweetened beverages SP - E157 EP - 63 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 22 IS - 5 N2 - OBJECTIVE: The purpose of this study was to examine the relationship between usual sugar-sweetened beverage (SSB) consumption and prevalence of abnormal metabolic health across body mass index (BMI) categories. METHODS: The metabolic health of 6,842 non-diabetic adults was classified using cross-sectional data from the Framingham Heart Study Offspring (1998-2001) and Third Generation (2002-2005) cohorts. Adults were classified as normal weight, overweight or obese and, within these categories, metabolic health was defined based on five criteria-hypertension, elevated fasting glucose, elevated triglycerides, low HDL cholesterol, and insulin resistance. Individuals without metabolic abnormalities were considered metabolically healthy. Logistic regression was used to examine the associations between categories of SSB consumption and risk of metabolic health after stratification by BMI. RESULTS: Comparing the highest category of SSB consumers (median of 7 SSB per week) to the lowest category (non-consumers), odds ratios (95% confidence intervals) for metabolically abnormal phenotypes, compared to the metabolically normal, were 1.9 (1.1-3.4) among the obese, 2.0 (1.4-2.9) among the overweight, and 1.9 (1.4-2.6) among the normal weight individuals. CONCLUSIONS: In this cross-sectional analysis, it is observed that, irrespective of weight status, consumers of SSB were more likely to display metabolic abnormalities compared to non-consumers in a dose-dependent manner. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/24550031/Sugar_sweetened_beverages_and_prevalence_of_the_metabolically_abnormal_phenotype_in_the_Framingham_Heart_Study_ L2 - https://doi.org/10.1002/oby.20724 DB - PRIME DP - Unbound Medicine ER -