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Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.
Phytother Res 2014; 28(9):1315-9PR

Abstract

Crocetin is a natural carotenoid dicarboxylic acid that is found in the fruit of Gardenia jasminoides Ellis (Cape Jasmine) and in the stamen and pistil of Crocus sativus L. (saffron). It is used worldwide as an important spice, food colorant, and herbal medicine. In the current investigation, we have examined the cardiovascular effects of crocetin using stroke-prone spontaneously hypertensive rats (SHRSPs). Male SHRSPs (6 weeks old) were classified into three groups: a control group and two crocetin groups (25 and 50 mg/kg/day). The animals were given crocetin for 3 weeks. Body weights in each group were not significantly different during the treatment period, but the increase in systolic blood pressures observed with age was significantly moderated by crocetin. Thrombogenesis, assessed using a He-Ne laser technique in pial vessels, was significantly decreased. Antioxidant activity, assessed by measuring urinary 8-hydroxy-2'-deoxyguanosine levels, together with urinary nitric oxide (NO) metabolite levels, was increased significantly after treatment. Acetylcholine-induced vasodilation was measured using the aorta and indicated that endothelial function was significantly improved by crocetin. These results strongly suggest that the antihypertensive and antithrombotic effects of crocetin were related to an increase in bioavailable NO, possibly mediated by decreased inactivation of NO by reactive oxygen species.

Authors+Show Affiliations

Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Nishi-Ku, Kobe, 651-2180, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24550159

Citation

Higashino, Saori, et al. "Crocetin, a Carotenoid From Gardenia Jasminoides Ellis, Protects Against Hypertension and Cerebral Thrombogenesis in Stroke-prone Spontaneously Hypertensive Rats." Phytotherapy Research : PTR, vol. 28, no. 9, 2014, pp. 1315-9.
Higashino S, Sasaki Y, Giddings JC, et al. Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Phytother Res. 2014;28(9):1315-9.
Higashino, S., Sasaki, Y., Giddings, J. C., Hyodo, K., Sakata, S. F., Matsuda, K., ... Yamamoto, J. (2014). Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Phytotherapy Research : PTR, 28(9), pp. 1315-9. doi:10.1002/ptr.5130.
Higashino S, et al. Crocetin, a Carotenoid From Gardenia Jasminoides Ellis, Protects Against Hypertension and Cerebral Thrombogenesis in Stroke-prone Spontaneously Hypertensive Rats. Phytother Res. 2014;28(9):1315-9. PubMed PMID: 24550159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. AU - Higashino,Saori, AU - Sasaki,Yasuto, AU - Giddings,John C, AU - Hyodo,Kanae, AU - Sakata,Shigeko Fujimoto, AU - Matsuda,Koichi, AU - Horikawa,Yoko, AU - Yamamoto,Junichiro, Y1 - 2014/02/18/ PY - 2012/09/11/received PY - 2014/01/14/revised PY - 2014/01/17/accepted PY - 2014/2/20/entrez PY - 2014/2/20/pubmed PY - 2014/11/5/medline KW - antioxidant KW - crocetin KW - nitric oxide KW - stroke-prone spontaneously hypertensive rats KW - thrombosis SP - 1315 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 28 IS - 9 N2 - Crocetin is a natural carotenoid dicarboxylic acid that is found in the fruit of Gardenia jasminoides Ellis (Cape Jasmine) and in the stamen and pistil of Crocus sativus L. (saffron). It is used worldwide as an important spice, food colorant, and herbal medicine. In the current investigation, we have examined the cardiovascular effects of crocetin using stroke-prone spontaneously hypertensive rats (SHRSPs). Male SHRSPs (6 weeks old) were classified into three groups: a control group and two crocetin groups (25 and 50 mg/kg/day). The animals were given crocetin for 3 weeks. Body weights in each group were not significantly different during the treatment period, but the increase in systolic blood pressures observed with age was significantly moderated by crocetin. Thrombogenesis, assessed using a He-Ne laser technique in pial vessels, was significantly decreased. Antioxidant activity, assessed by measuring urinary 8-hydroxy-2'-deoxyguanosine levels, together with urinary nitric oxide (NO) metabolite levels, was increased significantly after treatment. Acetylcholine-induced vasodilation was measured using the aorta and indicated that endothelial function was significantly improved by crocetin. These results strongly suggest that the antihypertensive and antithrombotic effects of crocetin were related to an increase in bioavailable NO, possibly mediated by decreased inactivation of NO by reactive oxygen species. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/24550159/Crocetin_a_carotenoid_from_Gardenia_jasminoides_Ellis_protects_against_hypertension_and_cerebral_thrombogenesis_in_stroke_prone_spontaneously_hypertensive_rats_ L2 - https://doi.org/10.1002/ptr.5130 DB - PRIME DP - Unbound Medicine ER -