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Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat ascaris lumbricoides, trichuris trichiura, and hookworm infection.
Antimicrob Agents Chemother. 2014 May; 58(5):2535-40.AA

Abstract

In many regions where soil-transmitted helminth infections are endemic, single-dose albendazole is used in mass drug administration programs to control infections. There are little data on the efficacy of the standard single-dose administration compared to that of alternative regimens. We conducted a randomized, controlled, assessor-blinded clinical trial to determine the efficacies of standard and extended albendazole treatment against soil-transmitted helminth infection in Gabon. A total of 175 children were included. Adequate cure rates and egg reduction rates above 85% were found with a single dose of albendazole for Ascaris infection, 85% (95% confidence interval [CI], 73, 96) and 93.8% (CI, 87.6, 100), respectively, while two doses were necessary for hookworm infestation (92% [CI, 78, 100] and 92% [CI, 78, 100], respectively). However, while a 3-day regimen was not sufficient to cure Trichuris (cure rate, 83% [CI, 73, 93]), this regimen reduced the number of eggs up to 90.6% (CI, 83.1, 100). The rate ratios of two- and three-dose regimens compared to a single-dose treatment were 1.7 (CI, 1.1, 2.5) and 2.1 (CI, 1.5, 2.9) for Trichuris and 1.7 (CI, 1.0, 2.9) and 1.7 (CI, 1.0, 2.9) for hookworm. Albendazole was safe and well tolerated in all regimens. A single-dose albendazole treatment considerably reduces Ascaris infection but has only a moderate effect on hookworm and Trichuris infections. The single-dose option may still be the preferred regimen because it balances efficacy, safety, and compliance during mass drug administration, keeping in mind that asymptomatic low-level helminth carriage may also have beneficial effects. (This study has been registered at ClinicalTrials.gov under registration number NCT01192802.).

Authors+Show Affiliations

Centre de Recherches Médicales de Lambaréné (CERMEL), Hôpital Albert Schweitzer, Lambaréné, Gabon.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24550339

Citation

Adegnika, Ayola A., et al. "Randomized, Controlled, Assessor-blind Clinical Trial to Assess the Efficacy of Single- Versus Repeated-dose Albendazole to Treat Ascaris Lumbricoides, Trichuris Trichiura, and Hookworm Infection." Antimicrobial Agents and Chemotherapy, vol. 58, no. 5, 2014, pp. 2535-40.
Adegnika AA, Zinsou JF, Issifou S, et al. Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat ascaris lumbricoides, trichuris trichiura, and hookworm infection. Antimicrob Agents Chemother. 2014;58(5):2535-40.
Adegnika, A. A., Zinsou, J. F., Issifou, S., Ateba-Ngoa, U., Kassa, R. F., Feugap, E. N., Honkpehedji, Y. J., Dejon Agobe, J. C., Kenguele, H. M., Massinga-Loembe, M., Agnandji, S. T., Mordmüller, B., Ramharter, M., Yazdanbakhsh, M., Kremsner, P. G., & Lell, B. (2014). Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat ascaris lumbricoides, trichuris trichiura, and hookworm infection. Antimicrobial Agents and Chemotherapy, 58(5), 2535-40. https://doi.org/10.1128/AAC.01317-13
Adegnika AA, et al. Randomized, Controlled, Assessor-blind Clinical Trial to Assess the Efficacy of Single- Versus Repeated-dose Albendazole to Treat Ascaris Lumbricoides, Trichuris Trichiura, and Hookworm Infection. Antimicrob Agents Chemother. 2014;58(5):2535-40. PubMed PMID: 24550339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized, controlled, assessor-blind clinical trial to assess the efficacy of single- versus repeated-dose albendazole to treat ascaris lumbricoides, trichuris trichiura, and hookworm infection. AU - Adegnika,Ayola A, AU - Zinsou,Jeannot F, AU - Issifou,Saadou, AU - Ateba-Ngoa,Ulysse, AU - Kassa,Roland F, AU - Feugap,Eliane N, AU - Honkpehedji,Yabo J, AU - Dejon Agobe,Jean-Claude, AU - Kenguele,Hilaire M, AU - Massinga-Loembe,Marguerite, AU - Agnandji,Selidji T, AU - Mordmüller,Benjamin, AU - Ramharter,Michael, AU - Yazdanbakhsh,Maria, AU - Kremsner,Peter G, AU - Lell,Bertrand, Y1 - 2014/02/18/ PY - 2014/2/20/entrez PY - 2014/2/20/pubmed PY - 2015/5/16/medline SP - 2535 EP - 40 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 58 IS - 5 N2 - In many regions where soil-transmitted helminth infections are endemic, single-dose albendazole is used in mass drug administration programs to control infections. There are little data on the efficacy of the standard single-dose administration compared to that of alternative regimens. We conducted a randomized, controlled, assessor-blinded clinical trial to determine the efficacies of standard and extended albendazole treatment against soil-transmitted helminth infection in Gabon. A total of 175 children were included. Adequate cure rates and egg reduction rates above 85% were found with a single dose of albendazole for Ascaris infection, 85% (95% confidence interval [CI], 73, 96) and 93.8% (CI, 87.6, 100), respectively, while two doses were necessary for hookworm infestation (92% [CI, 78, 100] and 92% [CI, 78, 100], respectively). However, while a 3-day regimen was not sufficient to cure Trichuris (cure rate, 83% [CI, 73, 93]), this regimen reduced the number of eggs up to 90.6% (CI, 83.1, 100). The rate ratios of two- and three-dose regimens compared to a single-dose treatment were 1.7 (CI, 1.1, 2.5) and 2.1 (CI, 1.5, 2.9) for Trichuris and 1.7 (CI, 1.0, 2.9) and 1.7 (CI, 1.0, 2.9) for hookworm. Albendazole was safe and well tolerated in all regimens. A single-dose albendazole treatment considerably reduces Ascaris infection but has only a moderate effect on hookworm and Trichuris infections. The single-dose option may still be the preferred regimen because it balances efficacy, safety, and compliance during mass drug administration, keeping in mind that asymptomatic low-level helminth carriage may also have beneficial effects. (This study has been registered at ClinicalTrials.gov under registration number NCT01192802.). SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/24550339/Randomized_controlled_assessor_blind_clinical_trial_to_assess_the_efficacy_of_single__versus_repeated_dose_albendazole_to_treat_ascaris_lumbricoides_trichuris_trichiura_and_hookworm_infection_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=24550339 DB - PRIME DP - Unbound Medicine ER -