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Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review.
Nutr Rev. 2014 Jan; 72(1):55-64.NR

Abstract

Adequate folate status in early pregnancy is critical to prevent congenital malformations, yet little is known about whether exposure to folate, specifically folic acid supplementation beyond the recommended dose, influences chronic health outcomes. The link between maternal folate levels and risk of childhood asthma and allergic disease has been investigated in 10 large prospective cohort studies that reported conflicting results. While the majority of studies reported no association, those supporting a positive relationship found a small increase in risk that was generally transient in nature, confined to early childhood, and associated with folic acid supplementation in late pregnancy. This systematic review presents background information on maternal folate exposure and childhood asthma, synthesizes the current epidemiologic evidence in the context of the methodological differences among studies and their potential limitations, and offers direction for future research.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

24551950

Citation

Brown, Susan B., et al. "Maternal Folate Exposure in Pregnancy and Childhood Asthma and Allergy: a Systematic Review." Nutrition Reviews, vol. 72, no. 1, 2014, pp. 55-64.
Brown SB, Reeves KW, Bertone-Johnson ER. Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review. Nutr Rev. 2014;72(1):55-64.
Brown, S. B., Reeves, K. W., & Bertone-Johnson, E. R. (2014). Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review. Nutrition Reviews, 72(1), 55-64.
Brown SB, Reeves KW, Bertone-Johnson ER. Maternal Folate Exposure in Pregnancy and Childhood Asthma and Allergy: a Systematic Review. Nutr Rev. 2014;72(1):55-64. PubMed PMID: 24551950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review. AU - Brown,Susan B, AU - Reeves,Katherine W, AU - Bertone-Johnson,Elizabeth R, PY - 2014/2/21/entrez PY - 2014/2/21/pubmed PY - 2014/4/15/medline SP - 55 EP - 64 JF - Nutrition reviews JO - Nutr Rev VL - 72 IS - 1 N2 - Adequate folate status in early pregnancy is critical to prevent congenital malformations, yet little is known about whether exposure to folate, specifically folic acid supplementation beyond the recommended dose, influences chronic health outcomes. The link between maternal folate levels and risk of childhood asthma and allergic disease has been investigated in 10 large prospective cohort studies that reported conflicting results. While the majority of studies reported no association, those supporting a positive relationship found a small increase in risk that was generally transient in nature, confined to early childhood, and associated with folic acid supplementation in late pregnancy. This systematic review presents background information on maternal folate exposure and childhood asthma, synthesizes the current epidemiologic evidence in the context of the methodological differences among studies and their potential limitations, and offers direction for future research. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/24551950/Maternal_folate_exposure_in_pregnancy_and_childhood_asthma_and_allergy:_a_systematic_review_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/nure.12080 DB - PRIME DP - Unbound Medicine ER -