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Relationships between impulsivity and subjective response in an IV ethanol paradigm.
Psychopharmacology (Berl). 2014 Jul; 231(14):2867-76.P

Abstract

RATIONALE

Impulsivity and individual differences in subjective response to alcohol are risk factors for alcohol problems and possibly endophenotypes for alcohol dependence. Few prior studies have addressed relationships between the two constructs.

OBJECTIVES

To predict subjective responses to ethanol, we tested self-reported impulsiveness, ethanol dose condition (high dose, low dose, or placebo), and time (seven time points) along with interactions among these variables.

METHODS

The present study is a secondary analysis of data from a within-subject, placebo-controlled, dose-ranging ethanol administration study using IV infusion with a clamping technique to maintain steady-state breath alcohol concentration. The sample consisted of healthy, non-alcohol dependent social alcohol drinkers between the ages of 21 and 30 (N=105). Participants at varying levels of impulsivity were compared with regard to stimulant and subjective responses to three ethanol dose conditions over time.

RESULTS

Individuals with higher impulsivity reported elavated stimulant and dampened sedative response to alcohol, particularly at the higher dose. Higher impulsivity was associated with a steeper increase in stimulant effects during the first half of clamped ethanol infusion with the higher dose.

CONCLUSIONS

These results suggest that impulsive individuals may experience enhanced reinforcing, stimulant effects, and relatively muted aversive sedative effects from alcohol. These subjective responses may relate to enhanced risk of alcohol problems among more impulsive individuals.

Authors+Show Affiliations

Department of Psychiatry, Yale School of Medicine, CMHC, Room S200, 34 Park Street, New Haven, CT, 06519, USA, robert.leeman@yale.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24553574

Citation

Leeman, Robert F., et al. "Relationships Between Impulsivity and Subjective Response in an IV Ethanol Paradigm." Psychopharmacology, vol. 231, no. 14, 2014, pp. 2867-76.
Leeman RF, Ralevski E, Limoncelli D, et al. Relationships between impulsivity and subjective response in an IV ethanol paradigm. Psychopharmacology (Berl). 2014;231(14):2867-76.
Leeman, R. F., Ralevski, E., Limoncelli, D., Pittman, B., O'Malley, S. S., & Petrakis, I. L. (2014). Relationships between impulsivity and subjective response in an IV ethanol paradigm. Psychopharmacology, 231(14), 2867-76. https://doi.org/10.1007/s00213-014-3458-9
Leeman RF, et al. Relationships Between Impulsivity and Subjective Response in an IV Ethanol Paradigm. Psychopharmacology (Berl). 2014;231(14):2867-76. PubMed PMID: 24553574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between impulsivity and subjective response in an IV ethanol paradigm. AU - Leeman,Robert F, AU - Ralevski,Elizabeth, AU - Limoncelli,Diana, AU - Pittman,Brian, AU - O'Malley,Stephanie S, AU - Petrakis,Ismene L, Y1 - 2014/02/20/ PY - 2013/08/14/received PY - 2014/01/14/accepted PY - 2014/2/21/entrez PY - 2014/2/21/pubmed PY - 2015/2/11/medline SP - 2867 EP - 76 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 231 IS - 14 N2 - RATIONALE: Impulsivity and individual differences in subjective response to alcohol are risk factors for alcohol problems and possibly endophenotypes for alcohol dependence. Few prior studies have addressed relationships between the two constructs. OBJECTIVES: To predict subjective responses to ethanol, we tested self-reported impulsiveness, ethanol dose condition (high dose, low dose, or placebo), and time (seven time points) along with interactions among these variables. METHODS: The present study is a secondary analysis of data from a within-subject, placebo-controlled, dose-ranging ethanol administration study using IV infusion with a clamping technique to maintain steady-state breath alcohol concentration. The sample consisted of healthy, non-alcohol dependent social alcohol drinkers between the ages of 21 and 30 (N=105). Participants at varying levels of impulsivity were compared with regard to stimulant and subjective responses to three ethanol dose conditions over time. RESULTS: Individuals with higher impulsivity reported elavated stimulant and dampened sedative response to alcohol, particularly at the higher dose. Higher impulsivity was associated with a steeper increase in stimulant effects during the first half of clamped ethanol infusion with the higher dose. CONCLUSIONS: These results suggest that impulsive individuals may experience enhanced reinforcing, stimulant effects, and relatively muted aversive sedative effects from alcohol. These subjective responses may relate to enhanced risk of alcohol problems among more impulsive individuals. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/24553574/Relationships_between_impulsivity_and_subjective_response_in_an_IV_ethanol_paradigm_ L2 - https://dx.doi.org/10.1007/s00213-014-3458-9 DB - PRIME DP - Unbound Medicine ER -