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Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.
Psychopharmacology (Berl). 2014 Aug; 231(15):2909-19.P

Abstract

RATIONALE AND OBJECTIVES

A conditioned stimulus (CS) is associated with a fearful unconditioned stimulus (US) in the traditional fear conditioning model. After fear conditioning, the CS-US association memory undergoes the consolidation process to become stable. Consolidated memory enters an unstable state after retrieval and requires the reconsolidation process to stabilize again. Evidence indicates the important role of Rac (Ras-related C3 botulinum toxin substrate) in the acquisition and extinction of fear memory. In the present study, we hypothesized that Rac in the amygdala is crucial for the reconsolidation of auditory and contextual Pavlovian fear memory.

METHODS

Auditory and contextual fear conditioning and microinjections of the Rac inhibitor NSC23766 were used to explore the role of Rac in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.

RESULTS

A microinjection of NSC23766 into the basolateral amygdala (BLA) but not central amygdala (CeA) or cornu ammonis 1 (CA1) immediately after memory retrieval disrupted the reconsolidation of auditory Pavlovian fear memory. A microinjection of NSC23766 into the CA1 but not BLA or CeA after memory retrieval disrupted the reconsolidation of contextual Pavlovian fear memory.

CONCLUSIONS

Our experiments demonstrate that Rac in the BLA is crucial for the reconsolidation of auditory Pavlovian fear memory, whereas Rac in the CA1 is critical for the reconsolidation of contextual Pavlovian fear memory.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wu P
National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Beijing, 100191, China.
Ding ZB
No affiliation info available
Meng SQ
No affiliation info available
Shen HW
No affiliation info available
Sun SC
No affiliation info available
Luo YX
No affiliation info available
Liu JF
No affiliation info available
Lu L
No affiliation info available
Zhu WL
No affiliation info available
Shi J
No affiliation info available

MeSH

AminoquinolinesAmygdalaAnimalsAuditory PerceptionBasolateral Nuclear ComplexCA1 Region, HippocampalCentral Nervous System AgentsConditioning, ClassicalExtinction, PsychologicalFearFreezing Reaction, CatalepticMemoryPyrimidinesRats, Sprague-Dawleyrac1 GTP-Binding Protein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24553575

Citation

Wu, Ping, et al. "Differential Role of Rac in the Basolateral Amygdala and Cornu Ammonis 1 in the Reconsolidation of Auditory and Contextual Pavlovian Fear Memory in Rats." Psychopharmacology, vol. 231, no. 15, 2014, pp. 2909-19.
Wu P, Ding ZB, Meng SQ, et al. Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. Psychopharmacology (Berl). 2014;231(15):2909-19.
Wu, P., Ding, Z. B., Meng, S. Q., Shen, H. W., Sun, S. C., Luo, Y. X., Liu, J. F., Lu, L., Zhu, W. L., & Shi, J. (2014). Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. Psychopharmacology, 231(15), 2909-19. https://doi.org/10.1007/s00213-014-3462-0
Wu P, et al. Differential Role of Rac in the Basolateral Amygdala and Cornu Ammonis 1 in the Reconsolidation of Auditory and Contextual Pavlovian Fear Memory in Rats. Psychopharmacology (Berl). 2014;231(15):2909-19. PubMed PMID: 24553575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. AU - Wu,Ping, AU - Ding,Zeng-Bo, AU - Meng,Shi-Qiu, AU - Shen,Hao-Wei, AU - Sun,Shi-Chao, AU - Luo,Yi-Xiao, AU - Liu,Jian-Feng, AU - Lu,Lin, AU - Zhu,Wei-Li, AU - Shi,Jie, Y1 - 2014/02/20/ PY - 2013/10/10/received PY - 2014/01/20/accepted PY - 2014/2/21/entrez PY - 2014/2/21/pubmed PY - 2015/3/4/medline SP - 2909 EP - 19 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 231 IS - 15 N2 - RATIONALE AND OBJECTIVES: A conditioned stimulus (CS) is associated with a fearful unconditioned stimulus (US) in the traditional fear conditioning model. After fear conditioning, the CS-US association memory undergoes the consolidation process to become stable. Consolidated memory enters an unstable state after retrieval and requires the reconsolidation process to stabilize again. Evidence indicates the important role of Rac (Ras-related C3 botulinum toxin substrate) in the acquisition and extinction of fear memory. In the present study, we hypothesized that Rac in the amygdala is crucial for the reconsolidation of auditory and contextual Pavlovian fear memory. METHODS: Auditory and contextual fear conditioning and microinjections of the Rac inhibitor NSC23766 were used to explore the role of Rac in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. RESULTS: A microinjection of NSC23766 into the basolateral amygdala (BLA) but not central amygdala (CeA) or cornu ammonis 1 (CA1) immediately after memory retrieval disrupted the reconsolidation of auditory Pavlovian fear memory. A microinjection of NSC23766 into the CA1 but not BLA or CeA after memory retrieval disrupted the reconsolidation of contextual Pavlovian fear memory. CONCLUSIONS: Our experiments demonstrate that Rac in the BLA is crucial for the reconsolidation of auditory Pavlovian fear memory, whereas Rac in the CA1 is critical for the reconsolidation of contextual Pavlovian fear memory. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/24553575/Differential_role_of_Rac_in_the_basolateral_amygdala_and_cornu_ammonis_1_in_the_reconsolidation_of_auditory_and_contextual_Pavlovian_fear_memory_in_rats_ DB - PRIME DP - Unbound Medicine ER -