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Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk.
J Nutr. 2014 Apr; 144(4):504-10.JN

Abstract

Although experimental data suggest a potentially protective involvement of dietary fiber in prostate carcinogenesis, very few prospective studies have investigated the relation between dietary fiber intake and prostate cancer risk, and those have had inconsistent results. Our objective was to study the association between dietary fiber intake (overall, insoluble, soluble, and from different sources, such as cereals, vegetables, fruits, and legumes) and prostate cancer risk. Stratifications by excess weight status, insulin-like growth factors, and amount of alcohol intake were also considered. This prospective analysis included 3313 men from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort who completed at least 3 24-h dietary records. One hundred thirty-nine incident prostate cancers were diagnosed between 1994 and 2007 (median follow-up of 12.6 y). Associations between quartiles of energy-adjusted dietary fiber intake and prostate cancer risk were characterized by multivariate Cox proportional hazards models. Prostate cancer risk was inversely associated with total dietary fiber intake (HR of quartile 4 vs. quartile 1 = 0.47; 95% CI: 0.27, 0.81; P = 0.001), insoluble (HR = 0.46; 95% CI: 0.27, 0.78; P = 0.001), and legume (HR = 0.55; 95% CI: 0.32, 0.95; P = 0.04) fiber intakes. In contrast, we found no association between prostate cancer risk and soluble (P = 0.1), cereal (P = 0.7), vegetable (P = 0.9), and fruit (P = 0.4) fiber intakes. In conclusion, dietary fiber intake (total, insoluble, and from legumes but not soluble or from cereals, vegetables, and fruits) was inversely associated with prostate cancer risk, consistent with mechanistic data.

Authors+Show Affiliations

Sorbonne Paris Cité Research Center, Nutritional Epidemiology Research Team, U1153 National Institute of Health and Medical Research, U1125 National Institute for Agricultural Research, National Conservatory of Arts and Crafts, Paris 13 University, Bobigny, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24553693

Citation

Deschasaux, Mélanie, et al. "Dietary Total and Insoluble Fiber Intakes Are Inversely Associated With Prostate Cancer Risk." The Journal of Nutrition, vol. 144, no. 4, 2014, pp. 504-10.
Deschasaux M, Pouchieu C, His M, et al. Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk. J Nutr. 2014;144(4):504-10.
Deschasaux, M., Pouchieu, C., His, M., Hercberg, S., Latino-Martel, P., & Touvier, M. (2014). Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk. The Journal of Nutrition, 144(4), 504-10. https://doi.org/10.3945/jn.113.189670
Deschasaux M, et al. Dietary Total and Insoluble Fiber Intakes Are Inversely Associated With Prostate Cancer Risk. J Nutr. 2014;144(4):504-10. PubMed PMID: 24553693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk. AU - Deschasaux,Mélanie, AU - Pouchieu,Camille, AU - His,Mathilde, AU - Hercberg,Serge, AU - Latino-Martel,Paule, AU - Touvier,Mathilde, Y1 - 2014/02/19/ PY - 2014/2/21/entrez PY - 2014/2/21/pubmed PY - 2014/5/23/medline SP - 504 EP - 10 JF - The Journal of nutrition JO - J. Nutr. VL - 144 IS - 4 N2 - Although experimental data suggest a potentially protective involvement of dietary fiber in prostate carcinogenesis, very few prospective studies have investigated the relation between dietary fiber intake and prostate cancer risk, and those have had inconsistent results. Our objective was to study the association between dietary fiber intake (overall, insoluble, soluble, and from different sources, such as cereals, vegetables, fruits, and legumes) and prostate cancer risk. Stratifications by excess weight status, insulin-like growth factors, and amount of alcohol intake were also considered. This prospective analysis included 3313 men from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort who completed at least 3 24-h dietary records. One hundred thirty-nine incident prostate cancers were diagnosed between 1994 and 2007 (median follow-up of 12.6 y). Associations between quartiles of energy-adjusted dietary fiber intake and prostate cancer risk were characterized by multivariate Cox proportional hazards models. Prostate cancer risk was inversely associated with total dietary fiber intake (HR of quartile 4 vs. quartile 1 = 0.47; 95% CI: 0.27, 0.81; P = 0.001), insoluble (HR = 0.46; 95% CI: 0.27, 0.78; P = 0.001), and legume (HR = 0.55; 95% CI: 0.32, 0.95; P = 0.04) fiber intakes. In contrast, we found no association between prostate cancer risk and soluble (P = 0.1), cereal (P = 0.7), vegetable (P = 0.9), and fruit (P = 0.4) fiber intakes. In conclusion, dietary fiber intake (total, insoluble, and from legumes but not soluble or from cereals, vegetables, and fruits) was inversely associated with prostate cancer risk, consistent with mechanistic data. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/24553693/Dietary_total_and_insoluble_fiber_intakes_are_inversely_associated_with_prostate_cancer_risk_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.113.189670 DB - PRIME DP - Unbound Medicine ER -