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The sensitivity of uremic and normal human skin to histamine.
Acta Derm Venereol. 1988; 68(3):230-5.AD

Abstract

Cutaneous reactions induced by intradermal histamine injection were studied in uremic patients with and without pruritus who were undergoing maintenance hemodialysis and also in healthy subjects. Flare reactions were significantly smaller in both groups of patients than in controls. However, the itch responses following histamine injection were greater in patients with pruritus than in non-pruritic patients and healthy subjects, indicating an augmented sensitivity to pruritogens in these patients. The development of histamine tachyphylaxis was demonstrated in healthy human skin. After repeated histamine injections at intervals of 90 min, both itch and flare responses decreased rapidly. A similar decline in histamine reactivity occurred when the interval between injections was extended to 24 h. The phenomenon of histamine tolerance was confirmed in 2 uremic patients.

Authors+Show Affiliations

Ståhle-Bäckdahl M
Department of Dermatololgy, Karolinska Sjukhuset, Stockholm, Sweden.
Hägermark O
No affiliation info available
Lins LE
No affiliation info available

MeSH

AdultAgedFemaleHistamineHumansIntradermal TestsKidney Failure, ChronicMaleMiddle AgedPruritusRenal DialysisSkinTachyphylaxis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2455416

Citation

Ståhle-Bäckdahl, M, et al. "The Sensitivity of Uremic and Normal Human Skin to Histamine." Acta Dermato-venereologica, vol. 68, no. 3, 1988, pp. 230-5.
Ståhle-Bäckdahl M, Hägermark O, Lins LE. The sensitivity of uremic and normal human skin to histamine. Acta Derm Venereol. 1988;68(3):230-5.
Ståhle-Bäckdahl, M., Hägermark, O., & Lins, L. E. (1988). The sensitivity of uremic and normal human skin to histamine. Acta Dermato-venereologica, 68(3), 230-5.
Ståhle-Bäckdahl M, Hägermark O, Lins LE. The Sensitivity of Uremic and Normal Human Skin to Histamine. Acta Derm Venereol. 1988;68(3):230-5. PubMed PMID: 2455416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sensitivity of uremic and normal human skin to histamine. AU - Ståhle-Bäckdahl,M, AU - Hägermark,O, AU - Lins,L E, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 230 EP - 5 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 68 IS - 3 N2 - Cutaneous reactions induced by intradermal histamine injection were studied in uremic patients with and without pruritus who were undergoing maintenance hemodialysis and also in healthy subjects. Flare reactions were significantly smaller in both groups of patients than in controls. However, the itch responses following histamine injection were greater in patients with pruritus than in non-pruritic patients and healthy subjects, indicating an augmented sensitivity to pruritogens in these patients. The development of histamine tachyphylaxis was demonstrated in healthy human skin. After repeated histamine injections at intervals of 90 min, both itch and flare responses decreased rapidly. A similar decline in histamine reactivity occurred when the interval between injections was extended to 24 h. The phenomenon of histamine tolerance was confirmed in 2 uremic patients. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/2455416/The_sensitivity_of_uremic_and_normal_human_skin_to_histamine_ DB - PRIME DP - Unbound Medicine ER -