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Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis.
Acta Derm Venereol 2014; 94(6):691-4AD

Abstract

Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.

Authors+Show Affiliations

Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24556829

Citation

Jensen, Peter, et al. "Effect of Weight Loss On the Cardiovascular Risk Profile of Obese Patients With Psoriasis." Acta Dermato-venereologica, vol. 94, no. 6, 2014, pp. 691-4.
Jensen P, Zachariae C, Christensen R, et al. Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis. Acta Derm Venereol. 2014;94(6):691-4.
Jensen, P., Zachariae, C., Christensen, R., Geiker, N. R., Schaadt, B. K., Stender, S., ... Skov, L. (2014). Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis. Acta Dermato-venereologica, 94(6), pp. 691-4. doi:10.2340/00015555-1824.
Jensen P, et al. Effect of Weight Loss On the Cardiovascular Risk Profile of Obese Patients With Psoriasis. Acta Derm Venereol. 2014;94(6):691-4. PubMed PMID: 24556829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis. AU - Jensen,Peter, AU - Zachariae,Claus, AU - Christensen,Robin, AU - Geiker,Nina R W, AU - Schaadt,Bente K, AU - Stender,Steen, AU - Astrup,Arne, AU - Hansen,Peter R, AU - Skov,Lone, PY - 2014/2/22/entrez PY - 2014/2/22/pubmed PY - 2015/7/8/medline SP - 691 EP - 4 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 94 IS - 6 N2 - Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/24556829/full_citation L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1824 DB - PRIME DP - Unbound Medicine ER -