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Circulating omega-3 Fatty acids and neovascular age-related macular degeneration.

Abstract

PURPOSE

We assessed the associations of serum, red blood cell membranes (RBCM) and dietary long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) with neovascular age-related macular degeneration (AMD).

METHODS

We included 290 patients of the Nutritional AMD Treatment 2 Study (NAT2) with neovascular AMD in one eye and early AMD lesions in the other eye, and 144 normal vision controls without AMD. Dietary intake of seafood was estimated by food frequency questionnaire. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) composition in serum and RBCM were determined by gas chromatography from 12-hour fasting blood samples and was expressed as percentages of total fatty acids profile. Logistic regressions estimated associations of neovascular AMD with dietary intake of seafood and circulating n-3 LC-PUFAs.

RESULTS

Dietary oily fish and seafood intake were significantly lower in AMD patients than in controls. After adjustment for all potential confounders (age, sex, CFH Y402H, ARMS2 A69S, and ApoE4 polymorphisms, plasma triglycerides, hypertension, hypercholesterolemia, and family history of AMD), serum EPA was associated significantly with a lower risk for neovascular AMD (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.22-0.77; P = 0.005). Analysis of RBCM revealed that EPA and EPA+DHA were associated significantly with a lower risk for neovascular AMD (OR = 0.25; 95% CI, 0.13-0.47; P < 0.0001 and OR = 0.52; 95% CI, 0.29-0.94; P = 0.03, respectively).

CONCLUSIONS

The RBCM EPA and EPA+DHA, as long-term biomarkers of n-3 dietary PUFA status, were associated strongly with neovascular AMD and may represent an objective marker identifying subjects at high risk for neovascular AMD, who may most benefit from nutritional interventions. (http://www.controlled-trials.com/isrctn number, ISRCTN98246501).

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  • Authors+Show Affiliations

    ,

    Ophthalmology Department, Hôpital Intercommunal de Créteil, University Paris Est Créteil, Créteil, France.

    , , , , ,

    Source

    MeSH

    Aged
    Chromatography, Gas
    Double-Blind Method
    Fatty Acids, Omega-3
    Female
    Fish Oils
    Follow-Up Studies
    Humans
    Macular Degeneration
    Male
    Retinal Neovascularization
    Retrospective Studies
    Surveys and Questionnaires
    Treatment Outcome

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24557349

    Citation

    Merle, Bénédicte M J., et al. "Circulating Omega-3 Fatty Acids and Neovascular Age-related Macular Degeneration." Investigative Ophthalmology & Visual Science, vol. 55, no. 3, 2014, pp. 2010-9.
    Merle BM, Benlian P, Puche N, et al. Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55(3):2010-9.
    Merle, B. M., Benlian, P., Puche, N., Bassols, A., Delcourt, C., & Souied, E. H. (2014). Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Investigative Ophthalmology & Visual Science, 55(3), pp. 2010-9. doi:10.1167/iovs.14-13916.
    Merle BM, et al. Circulating Omega-3 Fatty Acids and Neovascular Age-related Macular Degeneration. Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):2010-9. PubMed PMID: 24557349.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. AU - Merle,Bénédicte M J, AU - Benlian,Pascale, AU - Puche,Nathalie, AU - Bassols,Ana, AU - Delcourt,Cécile, AU - Souied,Eric H, AU - ,, Y1 - 2014/03/28/ PY - 2014/2/22/entrez PY - 2014/2/22/pubmed PY - 2014/5/7/medline KW - age-related macular degeneration KW - case-control study KW - epidemiology KW - omega-3 fatty acids SP - 2010 EP - 9 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 55 IS - 3 N2 - PURPOSE: We assessed the associations of serum, red blood cell membranes (RBCM) and dietary long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) with neovascular age-related macular degeneration (AMD). METHODS: We included 290 patients of the Nutritional AMD Treatment 2 Study (NAT2) with neovascular AMD in one eye and early AMD lesions in the other eye, and 144 normal vision controls without AMD. Dietary intake of seafood was estimated by food frequency questionnaire. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) composition in serum and RBCM were determined by gas chromatography from 12-hour fasting blood samples and was expressed as percentages of total fatty acids profile. Logistic regressions estimated associations of neovascular AMD with dietary intake of seafood and circulating n-3 LC-PUFAs. RESULTS: Dietary oily fish and seafood intake were significantly lower in AMD patients than in controls. After adjustment for all potential confounders (age, sex, CFH Y402H, ARMS2 A69S, and ApoE4 polymorphisms, plasma triglycerides, hypertension, hypercholesterolemia, and family history of AMD), serum EPA was associated significantly with a lower risk for neovascular AMD (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.22-0.77; P = 0.005). Analysis of RBCM revealed that EPA and EPA+DHA were associated significantly with a lower risk for neovascular AMD (OR = 0.25; 95% CI, 0.13-0.47; P < 0.0001 and OR = 0.52; 95% CI, 0.29-0.94; P = 0.03, respectively). CONCLUSIONS: The RBCM EPA and EPA+DHA, as long-term biomarkers of n-3 dietary PUFA status, were associated strongly with neovascular AMD and may represent an objective marker identifying subjects at high risk for neovascular AMD, who may most benefit from nutritional interventions. (http://www.controlled-trials.com/isrctn number, ISRCTN98246501). SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24557349/Circulating_omega_3_Fatty_acids_and_neovascular_age_related_macular_degeneration_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-13916 DB - PRIME DP - Unbound Medicine ER -