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Increased risk of cancer for patients with ankylosing spondylitis: a nationwide population-based retrospective cohort study.
Scand J Rheumatol. 2014; 43(4):301-6.SJ

Abstract

OBJECTIVES

Few studies have investigated the relationship between ankylosing spondylitis (AS) and other inflammatory spondyloarthritis and subsequent cancer. The aim of this study was to determine whether AS is associated with cancer risk.

METHOD

We used data from the National Health Insurance (NHI) system of Taiwan to investigate this association. The AS cohort included 4133 patients, and each patient was randomly frequency matched with four persons without AS based on sex, age, and entry year (control cohort). We conducted a Cox proportional hazards regression analysis to estimate the influence of AS on cancer risk.

RESULTS

Among patients with AS, the overall risk of developing cancer was 38% higher than that of people without AS, and the difference was significant [adjusted hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.18-1.60]. This phenomenon held true even when we analysed males and females separately. The risk of developing lung or head and neck cancer among patients with AS was significantly higher; and risks for liver, bladder, and uterus cancers were marginally significantly higher.

CONCLUSIONS

This nationwide population-based cohort study shows that Taiwanese patients with AS have a higher risk of developing cancer, particularly lung or head and neck cancer.

Authors+Show Affiliations

Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital , Kaohsiung , Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24559186

Citation

Sun, L-M, et al. "Increased Risk of Cancer for Patients With Ankylosing Spondylitis: a Nationwide Population-based Retrospective Cohort Study." Scandinavian Journal of Rheumatology, vol. 43, no. 4, 2014, pp. 301-6.
Sun LM, Muo CH, Liang JA, et al. Increased risk of cancer for patients with ankylosing spondylitis: a nationwide population-based retrospective cohort study. Scand J Rheumatol. 2014;43(4):301-6.
Sun, L. M., Muo, C. H., Liang, J. A., Chang, S. N., Sung, F. C., & Kao, C. H. (2014). Increased risk of cancer for patients with ankylosing spondylitis: a nationwide population-based retrospective cohort study. Scandinavian Journal of Rheumatology, 43(4), 301-6. https://doi.org/10.3109/03009742.2013.863969
Sun LM, et al. Increased Risk of Cancer for Patients With Ankylosing Spondylitis: a Nationwide Population-based Retrospective Cohort Study. Scand J Rheumatol. 2014;43(4):301-6. PubMed PMID: 24559186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of cancer for patients with ankylosing spondylitis: a nationwide population-based retrospective cohort study. AU - Sun,L-M, AU - Muo,C-H, AU - Liang,J-A, AU - Chang,S-N, AU - Sung,F-C, AU - Kao,C-H, Y1 - 2014/02/24/ PY - 2014/2/25/entrez PY - 2014/2/25/pubmed PY - 2014/12/17/medline SP - 301 EP - 6 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 43 IS - 4 N2 - OBJECTIVES: Few studies have investigated the relationship between ankylosing spondylitis (AS) and other inflammatory spondyloarthritis and subsequent cancer. The aim of this study was to determine whether AS is associated with cancer risk. METHOD: We used data from the National Health Insurance (NHI) system of Taiwan to investigate this association. The AS cohort included 4133 patients, and each patient was randomly frequency matched with four persons without AS based on sex, age, and entry year (control cohort). We conducted a Cox proportional hazards regression analysis to estimate the influence of AS on cancer risk. RESULTS: Among patients with AS, the overall risk of developing cancer was 38% higher than that of people without AS, and the difference was significant [adjusted hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.18-1.60]. This phenomenon held true even when we analysed males and females separately. The risk of developing lung or head and neck cancer among patients with AS was significantly higher; and risks for liver, bladder, and uterus cancers were marginally significantly higher. CONCLUSIONS: This nationwide population-based cohort study shows that Taiwanese patients with AS have a higher risk of developing cancer, particularly lung or head and neck cancer. SN - 1502-7732 UR - https://www.unboundmedicine.com/medline/citation/24559186/Increased_risk_of_cancer_for_patients_with_ankylosing_spondylitis:_a_nationwide_population_based_retrospective_cohort_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/03009742.2013.863969 DB - PRIME DP - Unbound Medicine ER -