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Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release.

Abstract

The chloroform extract from Ganoderma lucidum broth markedly inhibited histamine release from rat peritoneal mast cells. From the active fractions, palmitic acid, stearic acid, oleic acid and linoleic acid were isolated. Oleic acid dose-dependently inhibited the histamine release and 45Ca uptake into mast cells induced by compound 48/80 and A-23187 at concentrations of 5 to 50 microM and 0.5 to 5 microM, respectively. Saturated fatty acids, however, had only a weak inhibitory effect on histamine release. Although linoleic acid and linolenic acid effectively prevented this release, these two compounds caused marked release at concentrations higher than 10 microM and 20 microM, respectively. Oleic acid induces membrane-stabilization in model membrane systems. It was concluded that one of the effective constituents obtainable from the chloroform extract of G. lucidum-cultured broth is oleic acid.

Authors+Show Affiliations

,

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

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Source

Agents and actions 23:3-4 1988 Apr pg 153-6

MeSH

Animals
Basidiomycota
Calcium
Histamine Antagonists
Histamine Release
In Vitro Techniques
Male
Mast Cells
Medicine, East Asian Traditional
Oleic Acid
Oleic Acids
Polyporaceae
Rats
Rats, Inbred Strains

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2455975

Citation

TY - JOUR T1 - Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release. AU - Tasaka,K, AU - Akagi,M, AU - Miyoshi,K, AU - Mio,M, AU - Makino,T, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 153 EP - 6 JF - Agents and actions JO - Agents Actions VL - 23 IS - 3-4 N2 - The chloroform extract from Ganoderma lucidum broth markedly inhibited histamine release from rat peritoneal mast cells. From the active fractions, palmitic acid, stearic acid, oleic acid and linoleic acid were isolated. Oleic acid dose-dependently inhibited the histamine release and 45Ca uptake into mast cells induced by compound 48/80 and A-23187 at concentrations of 5 to 50 microM and 0.5 to 5 microM, respectively. Saturated fatty acids, however, had only a weak inhibitory effect on histamine release. Although linoleic acid and linolenic acid effectively prevented this release, these two compounds caused marked release at concentrations higher than 10 microM and 20 microM, respectively. Oleic acid induces membrane-stabilization in model membrane systems. It was concluded that one of the effective constituents obtainable from the chloroform extract of G. lucidum-cultured broth is oleic acid. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/2455975/full_citation/Anti_allergic_constituents_in_the_culture_medium_of_Ganoderma_lucidum___I___Inhibitory_effect_of_oleic_acid_on_histamine_release_ ER -