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Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release.

Abstract

For centuries, Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constituents was cyclooctasulfur. The latter effectively inhibited histamine release from rat peritoneal mast cells and impeded 45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit 45Ca uptake, and that this may be the main cause of histamine release inhibition.

Authors+Show Affiliations

,

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

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Source

Agents and actions 23:3-4 1988 Apr pg 157-60

MeSH

Animals
Basidiomycota
Histamine Antagonists
Histamine Release
In Vitro Techniques
Male
Mast Cells
Medicine, East Asian Traditional
Polyporaceae
Rats
Rats, Inbred Strains
Sulfur

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2455976

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release. AU - Tasaka,K, AU - Mio,M, AU - Izushi,K, AU - Akagi,M, AU - Makino,T, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 157 EP - 60 JF - Agents and actions JO - Agents Actions VL - 23 IS - 3-4 N2 - For centuries, Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constituents was cyclooctasulfur. The latter effectively inhibited histamine release from rat peritoneal mast cells and impeded 45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit 45Ca uptake, and that this may be the main cause of histamine release inhibition. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/2455976/full_citation/Anti_allergic_constituents_in_the_culture_medium_of_Ganoderma_lucidum___II___The_inhibitory_effect_of_cyclooctasulfur_on_histamine_release_ DB - PRIME DP - Unbound Medicine ER -