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Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release.

Abstract

For centuries, Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constituents was cyclooctasulfur. The latter effectively inhibited histamine release from rat peritoneal mast cells and impeded 45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit 45Ca uptake, and that this may be the main cause of histamine release inhibition.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

    , , ,

    Source

    Agents and actions 23:3-4 1988 Apr pg 157-60

    MeSH

    Animals
    Basidiomycota
    Histamine Antagonists
    Histamine Release
    In Vitro Techniques
    Male
    Mast Cells
    Medicine, East Asian Traditional
    Polyporaceae
    Rats
    Rats, Inbred Strains
    Sulfur

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    2455976